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    Implantable medical device
    2.
    发明授权
    Implantable medical device 有权
    植入式医疗器械

    公开(公告)号：US06270788B1

    公开(公告)日：2001-08-07

    申请号：US09411405

    申请日：1999-10-04

    申请人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

    发明人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

    IPC分类号： A61F1300

    CPC分类号： A61L33/0047 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  C08L33/14

    摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

    摘要翻译： 通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。 使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。 共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和 肝素生物活性。 一旦制成共聚物涂层，医用制品被涂覆。 然后将涂层干燥并加入肝素。 以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。

    Method for improving the biocompatibility of solid surfaces
    3.
    发明授权
    Method for improving the biocompatibility of solid surfaces 失效
    提高固体表面生物相容性的方法

    公开(公告)号：US5350800A

    公开(公告)日：1994-09-27

    申请号：US5711

    申请日：1993-01-19

    申请人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    发明人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    IPC分类号： A61L27/00 ,  A61L29/00 ,  A61L33/00 ,  A61L33/10 ,  A61F2/54 ,  A61F2/02 ,  A61K9/22

    CPC分类号： A61L33/0029 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/0088

    摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.

    摘要翻译： 通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法 到胺化的固体表面，然后选择性地将羧基还原成生物分子。 羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。 该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

    Method of treating the surface of a medical device with a biomolecule
    5.
    发明授权
    Method of treating the surface of a medical device with a biomolecule 有权
    用生物分子处理医疗器械表面的方法

    公开(公告)号：US08343567B2

    公开(公告)日：2013-01-01

    申请号：US13345813

    申请日：2012-01-09

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.

    摘要翻译： 一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

    METHOD OF TREATING THE SURFACE OF A MEDICAL DEVICE WITH A BIOMOLECULE
    6.
    发明申请
    METHOD OF TREATING THE SURFACE OF A MEDICAL DEVICE WITH A BIOMOLECULE 有权
    用生物分子处理医疗器械表面的方法

    公开(公告)号：US20120107901A1

    公开(公告)日：2012-05-03

    申请号：US13345813

    申请日：2012-01-09

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/10 ,  C12N11/08

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.

    摘要翻译： 一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

    Method for making improved heparinized biomaterials
    9.
    发明授权
    Method for making improved heparinized biomaterials 失效
    改善肝素化生物材料的方法

    公开(公告)号：US5767108A

    公开(公告)日：1998-06-16

    申请号：US518147

    申请日：1995-08-22

    申请人： Patrick Cahalan ,  Theo Lindhout ,  Benedict Fouache ,  Michel Verhoeven ,  Linda Cahalan ,  Marc Hendriks ,  Ron Blezer

    发明人： Patrick Cahalan ,  Theo Lindhout ,  Benedict Fouache ,  Michel Verhoeven ,  Linda Cahalan ,  Marc Hendriks ,  Ron Blezer

    IPC分类号： A61L33/00 ,  A61L33/12 ,  A61K31/70

    CPC分类号： A61L33/0029 ,  A61L33/128 ,  Y10S514/802 ,  Y10S514/822

    摘要： A method of treating a patient with a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophlactic properties of ATIII/heparin are obtained.

    摘要翻译： 在患有共价连接的肝素化表面的血液接触表面上用具有固定化肝素的医疗装置治疗患者的方法，所述吸附蛋白可被固定化肝素激活以阻断纤维蛋白原的凝结。 抗凝血酶III是优选的吸附蛋白。 吸附的蛋白质保持在固定化的肝素表面上，直到医疗装置与患者的血液接触。 当与患者的血液接触时，吸附的蛋白质将阻止在生物材料 - 血液界面处的初始凝血酶形成。 ATIII的预吸附在有利于最大肝素/ ATIII结合的条件下完成。 当预吸附的表面与全血接触时，获得了ATIII /肝素的前体特性的最大优点。

    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE
    10.
    发明申请
    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE 有权
    制备用生物分子涂覆的基材的方法

    公开(公告)号：US20080241349A1

    公开(公告)日：2008-10-02

    申请号：US12061212

    申请日：2008-04-02

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.

    摘要翻译： 提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。 涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。