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    Arylalkoxythiocoumarins, the preparation thereof and therapeutic compositions containing these
    7.
    发明授权
    Arylalkoxythiocoumarins, the preparation thereof and therapeutic compositions containing these 失效
    芳基烷氧基硫香环素，其制备方法和含有它们的治疗组合物

    公开(公告)号：US5414006A

    公开(公告)日：1995-05-09

    申请号：US136033

    申请日：1993-10-14

    申请人： Beatrice Rendenbach-Mueller ,  Ulrich Karl ,  Harald Weifenbach

    发明人： Beatrice Rendenbach-Mueller ,  Ulrich Karl ,  Harald Weifenbach

    IPC分类号： C07D311/16 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  A61K31/37

    CPC分类号： C07D405/12 ,  C07D311/16 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

    摘要： Arylalkoxythiocoumarins of the formula ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, hydrogen, C.sub.1 -C.sub.5 -alkyl, trifluoromethyl, phenyl or halogen, or together are a C.sub.3 -C.sub.5 -alkylene chain, andX is oxygen or sulfur,R.sup.3 is C.sub.1 -C.sub.5 -alkyl or halogen,n is an integer from 0 to 3,R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl andAr is phenyl, which can be mono- or disubstituted by halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy, nitro, cyano, trifluoromethyl or a combination of these substituents or is a heteraromatic ring which has from one to three heteroatoms which can, independently of one another, be N, O or S, and which can be substituted by C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.4 -alkoxy-substituted C.sub.1 -C.sub.6 -alkyl, 5-6-membered oxacycloalkyl, benzyl, C.sub.1 -C.sub.5 -alkoxycarbonyl, perfluoro-C.sub.1 -C.sub.2 -alkyl, phenyl or halogen, are prepared as described and used in therapeutic compositions, especially for treating disorders of the central nervous system.

    摘要翻译： 其中R 1和R 2各自独立地为氢，C 1 -C 5 - 烷基，三氟甲基，苯基或卤素，或一起为C 3 -C 5 - 亚烷基链，并且X为氧或芳基烷氧基， 硫，R3是C1-C5-烷基或卤素，n是0-3的整数，R4是氢或C1-C4-烷基，Ar是可以被卤素单 - 或二取代的苯基，C1-C6-烷基 C 3 -C 7 - 环烷基，C 1 -C 6 - 烷氧基，硝基，氰基，三氟甲基或这些取代基的组合，或者是具有1至3个杂原子的杂芳环，它们可以彼此独立地为N，O或S 可以被C 1 -C 6 - 烷基，C 3 -C 7 - 环烷基，C 1 -C 6 - 烷氧基，C 1 -C 4 - 烷氧基取代的C 1 -C 6 - 烷基，5-6元氧杂环烷基，苄基，C 1 -C 5 - 烷氧基羰基，全氟-C 1 - C 2 - 烷基，苯基或卤素，如治疗组合物中所述和使用，特别是用于治疗中枢神经系统疾病。

    Arylalkoxycoumarins
    8.
    发明授权
    Arylalkoxycoumarins 失效
    ARYLALKOXYCOUMARINS

    公开(公告)号：US5100914A

    公开(公告)日：1992-03-31

    申请号：US414307

    申请日：1989-09-29

    申请人： Beatrice Rendenbach-Mueller ,  Harald Weifenbach ,  Jans-Juergen Teschendorf

    发明人： Beatrice Rendenbach-Mueller ,  Harald Weifenbach ,  Jans-Juergen Teschendorf

    IPC分类号： A61K31/00 ,  A61K31/37 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  C07D311/16

    CPC分类号： C07D311/16

    摘要： Arylalkoxycoumarins of the general formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an alkylene bridge of 3 to 5 carbon atoms, R.sup.3 is lower alkyl or halogen, n is an integer of from 0 to 3, m is an integer of from 0 to 4, R.sup.4 is hydrogen or lower alkyl and Ar is a phenyl ring which is monosubstituted to trisubstituted by halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy or monosubstituted by nitro, cyano or trifluoromethyl or is a naphthyl ring, with the proviso that m is not 0 when Ar is unsubstituted phenyl, processes for their preparation, and drugs prepared therefrom.

    摘要翻译： 其中R 1和R 2彼此独立地为氢，低级烷基，苯基或卤素，或两个基团一起形成3至5个碳原子的亚烷基桥，R 3为低级烷基或 卤素，n为0〜3的整数，m为0〜4的整数，R4为氢或低级烷基，Ar为被卤素，C1-C6烷基或C1-C6烷基单取代为三取代的苯基环， C6烷氧基或被硝基，氰基或三氟甲基单取代或是萘环，条件是当Ar是未取代的苯基时m不为0，制备方法及由其制备的药物。