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1.发明授权Polynucleotide constructs for secreted glycosylated plasminogen activator inhibitor-2 (PAI-2) 失效用于分泌的糖基化纤溶酶原激活物抑制剂-2（PAI-2）的多核苷酸构建体
公开(公告)号：US5298400A
公开(公告)日：1994-03-29
申请号：US679052
申请日：1991-05-06
IPC分类号： G01N33/53 , A61K38/00 , A61K38/55 , A61K39/00 , A61K39/395 , A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C07K7/08 , C07K14/00 , C07K14/81 , C07K16/00 , C12N5/10 , C12N15/09 , C12N15/15 , C12N15/62 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577 , C12N15/03 , C12N15/06 , C12P21/02
CPC分类号： C07K14/8132 , C12N15/625 , A61K38/00 , C07K2319/02 , C07K2319/036 , C07K2319/91
摘要： This invention relates to PAI-2 and its expression as a recombinant molecule in eukaryotic cell lines as a glycosylated secreted molecule, to the constructs expressing it, to host cells expressing it, to compositions comprising it, to methods of treatment, prophylaxis and diagnosis using it and to antibodies raised against it. The invention also provides a 414 amino acid form of PAI-2 wherein the N-terminal methionine residue is deleted, a 60 kD glycosylated secreted recombinant form of PAI-2 and compositions and methods using these molecules. The invention further relates to a novel synthetic signal peptide.
摘要翻译： PCT No.PCT / AU90 / 00396 Sec。 371日期1991年5月6日 102（e）日1991年5月6日PCT 1990年9月4日PCT PCT。 出版物WO91 / 03556 1991年3月21日。本发明涉及PAI-2及其在作为糖基化分泌分子的真核细胞系中的重组分子，表达其的构建体，将其表达的宿主细胞，包含其的组合物的表达作为方法 使用它的治疗，预防和诊断以及对其产生的抗体。 本发明还提供了414位氨基酸形式的PAI-2，其中N末端甲硫氨酸残基被缺失，60kD糖基化分泌的重组形式的PAI-2以及使用这些分子的组合物和方法。 本发明还涉及一种新的合成信号肽。
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公开(公告)号：US5444153A
公开(公告)日：1995-08-22
申请号：US768286
申请日：1991-10-11
IPC分类号： G01N33/53 , A61K38/55 , A61K39/395 , A61K49/00 , A61K51/00 , A61P7/04 , A61P29/00 , A61P35/00 , C07K14/00 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12N15/15 , C12P21/02 , C12P21/08 , C12R1/19 , G01N33/577 , C12Q1/00
CPC分类号： C07K14/8132
摘要： Variants of the plasminogen activator inhibitor PAI-2 in which the 66-98 amino acid residue region has been altered to eliminate at least one protease sensitive site are provided. The variants of the invention maintain the biological activity of PAI-2 and amino acids up to 65 and from 99 of PAI-2 in frame. The PAI-2 variants of the invention in labelled form, as well as DNA molecules encoding the variants of the invention, transformed host cells expressing the variants of the invention compositions and diagnostic kits comprising the variants of the invention, antibodies against the variants of the invention and processes for the production of the variants, DNA molecules, transformed hosts, compositions and antibodies of the invention are also described.
摘要翻译： PCT No.PCT / AU90 / 00603 Sec。 371日期1991年10月11日 102（e）日期1991年10月11日PCT 1990年12月20日PCT PCT。 出版物WO91 / 09124 日期：1991年6月27日。提供其中66-98个氨基酸残基区被改变以消除至少一个蛋白酶敏感位点的纤溶酶原激活物抑制剂PAI-2的变体。 本发明的变体在框架中保持PAI-2和PAI-2的最高65和99的氨基酸的生物活性。 标记形式的本发明的PAI-2变体以及编码本发明变体的DNA分子转化表达本发明变体的宿主细胞组合物和包含本发明变体的诊断试剂盒， 还描述了用于生产本发明的变体，DNA分子，转化宿主，组合物和抗体的发明和方法。
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3.依法登记的发明
公开(公告)号：USH1717H
公开(公告)日：1998-04-07
申请号：US558998
申请日：1995-11-16
CPC分类号： H01L31/03042 , H01L31/08 , H01L31/09 , H01L31/186 , Y02E10/544 , Y02P70/521
摘要： A photoconductive switching device is disclosed that has an enhanced speed f response so that its closed (low) and open (high) resistive states are obtained in response to optical illumination in the less than nanosecond regime. The enhanced speed of response is achieved by neutron irradiation of a material preferably comprising GaAs:Si:Cu. An application of the improved photoconductive switching devices is disclosed which allows the realization of a high-power, frequency-agile RF source topology.
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公开(公告)号：US4764460A
公开(公告)日：1988-08-16
申请号：US796372
申请日：1985-11-08
IPC分类号： C12N15/09 , A61K35/74 , A61K35/76 , A61K38/00 , C07K14/14 , C07K17/02 , C07K17/14 , C12N1/00 , C12N5/10 , C12P21/00 , C12Q1/68 , C12Q1/70 , C12R1/07 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/645 , C12R1/91 , G01N33/50 , C12N15/00 , G01N33/566
CPC分类号： C07K14/005 , C12Q1/6804 , C12Q1/70 , C12Q1/701 , C12N2720/12022 , Y10S435/948
摘要： This disclosure relates to the synthesis by application of recombinant DNA technology of recombinant reovirus nonstructural protein sigma NS and its use as a non-specific binding agent for single stranded (ss) RNA's. This property of sigma NS protein can be employed when it is used as a reagent in protecting unstable RNA during extraction processes and more significantly as a reagent for the concentration of (ss) RNA samples for use in hybridization probe assays.
摘要翻译： 本公开涉及通过应用重组呼肠弧病毒非结构蛋白质σNS的重组DNA技术的合成及其作为单链（ss）RNA的非特异性结合剂的用途。 当sigma NS蛋白质在提取过程中用作保护不稳定RNA的试剂，并且更显着地作为用于杂交探针测定中使用的（ss）RNA样品的浓度的试剂时，可以使用该σ性质的NS蛋白质。
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5.依法登记的发明
公开(公告)号：USH1835H
公开(公告)日：2000-02-01
申请号：US788609
申请日：1997-01-24
IPC分类号： H01L31/0304 , H01L31/08 , H01L31/09 , H01L31/18 , H01L21/20
CPC分类号： H01L31/03042 , H01L31/08 , H01L31/09 , H01L31/186 , Y02E10/544 , Y02P70/521
摘要： A photoconductive switching device is disclosed that has an enhanced speed of response so that its closed (low) and open (high) resistive states are obtained in response to optical illumination in the less than nanosecond regime. The enhanced speed of response is achieved by neutron irradiation of a material preferably comprising GaAs:Si:Cu. An application of the improved photoconductive switching devices is disclosed which allows the realization of a high-power, frequency-agile RF source topology.
摘要翻译： 公开了一种具有增强的响应速度的光电导开关器件，使得其响应于小于纳秒范围内的光学照明获得其闭合（低）和开路（高）电阻状态。 增强的响应速度通过优选包括GaAs：Si：Cu的材料的中子照射来实现。 公开了改进的光电导开关器件的应用，其允许实现高功率，频率敏捷的RF源拓扑。
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6.发明授权
公开(公告)号：US5864166A
公开(公告)日：1999-01-26
申请号：US788631
申请日：1997-01-24
IPC分类号： H01L31/0304 , H01L31/08 , H01L31/09 , H01L31/18 , H01L27/14 , H01L29/167 , H01L29/207 , H01L31/10
CPC分类号： H01L31/03042 , H01L31/08 , H01L31/09 , H01L31/186 , Y02E10/544 , Y02P70/521
摘要： A photoconductive switching device is disclosed that has an enhanced speed of response so that its closed (low) and open (high) resistive states are obtained in response to optical illumination in the less than nanosecond regime. The enhanced speed of response is achieved by neutron irradiation of a material preferably comprising GaAs:Si:Cu. An application of the improved photoconductive switching devices is disclosed which allows the realization of a high-power, frequency-agile RF source topology.
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公开(公告)号：US07425035B2
公开(公告)日：2008-09-16
申请号：US11705311
申请日：2007-02-12
IPC分类号： B60N2/24
CPC分类号： A47C9/027
摘要： A gardening chair 10 is provided for supporting a user 12 thereon. The gardening chair 10 is provided with a base support member 14, and a seat 52 aligned with and coupled to upper portions of the base support member for supporting a user's lower body thereon. A diagonally extending chest support member 72 is provided for supporting a user's chest 12 and upper body thereon. An L-shaped tensioning arm 152 and an elastic band 156 are coupled to one end of intermediate portions of the diagonally extending chest support member 72 and the base support member 14 to support the member for movement to a plurality of predetermined diagonal positions.
摘要翻译： 设置有用于在其上支撑使用者12的园艺椅10。 园艺椅10设置有基部支撑构件14和与底座支撑构件的上部对准并联接以用于在其上支撑使用者的下身的座52。 设置有对角延伸的胸部支撑构件72，用于将使用者的胸部12和上身支撑在其上。 L形张紧臂152和弹性带156联接到对角线延伸的胸部支撑构件72和基部支撑构件14的中间部分的一端，以支撑构件移动到多个预定对角线位置。
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公开(公告)号：US06666499B2
公开(公告)日：2003-12-23
申请号：US10057347
申请日：2002-01-28
IPC分类号： B62C102
CPC分类号： B60J5/108 , B60J5/0497 , B60N2/01 , B62D31/00
摘要： A utility vehicle 10 is provided with an extended chassis 12. The utility vehicle 10 is provided to accommodate a driver's compartment 50 having a seat 56 for a driver and a plurality of passengers. A first passenger compartment 60 is provided behind the driver compartment 50 having a seat 62 for seating a second plurality of passengers thereon. A second passenger compartment 66 is formed on the extended chassis 12 behind the first passenger compartment 60. The second passenger compartment 66 is provided with a seat 68 for seating a third plurality of passengers thereon. A storage compartment 80 is also provided directly behind the second passenger compartment 66. Side access doors 58, 64 and 70 are provided for the driver's compartment, first passenger compartment 60 and second passenger compartment 66, respectively. A rear access door 84 is provided so that the cargo can be put in and taken out of the utility vehicle 10 as desired.
摘要翻译： 多用途车辆10设置有延伸底盘12.多用途车辆10被设置成容纳具有用于驾驶员和多个乘客的座位56的驾驶室50。 第一乘客室60设置在驾驶室50后面，驾驶室50具有用于将第二组乘客放在其上的座62。 第二乘客室66形成在第一乘客室60后面的延伸底盘12上。第二乘客室66设置有座椅68，用于将第三多个乘客放置在座椅68上。 储存室80也直接设置在第二乘客舱66的后面。侧面通道门58,64和70分别为驾驶室，第一客舱60和第二客舱66提供。 设置后检修门84，以便可以根据需要将货物放入多用途车辆10中取出。
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公开(公告)号：US4432667A
公开(公告)日：1984-02-21
申请号：US158302
申请日：1980-06-10
摘要： A tunnel or shaft lining is installed nondisruptively in a medium such as soil by longitudinally advancing an assembly (10) of tunnel lining sections (12-1 to 12-8) arranged in end-to-end relationship and having an inflatable torus (22- 1 to 22-7) interposed between adjacent sections. Worm-like advancement is effected by simultaneously inflating in sequence the tori 22-1, 22-4, 22-7 etc.; the tori 22-2, 22-5 etc. and the tori 22-3, 22-6 etc., and repeating the inflation procedure as necessary until sufficient advance has been achieved.
摘要翻译： 通过纵向推进以端对端关系布置的隧道衬里部分（12-1至12-8）的组件（10-1），并且具有充气环面（22），隧道或轴衬被非破坏地安装在诸如土壤的介质中 1〜22-7）。 通过同时依次对tori 22-1,22-4,22-7等进行充气来实现蠕虫状进展; 托里22-2,22-5等和托里22-3,22-6等，并根据需要重复充气程序，直到达到足够的进步。
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公开(公告)号：US07178868B2
公开(公告)日：2007-02-20
申请号：US10434705
申请日：2003-05-09
IPC分类号： B60N2/24
CPC分类号： A47C9/027
摘要： A gardening chair 10 is provided for supporting a user 12 thereon. The gardening chair 10 is provided with a base support member 14, and a seat 52 aligned with and coupled to upper portions of the base support member for supporting a user's lower body thereon. A diagonally extending chest support member 72 is provided for supporting a user's chest 12 and upper body thereon. A pair of elongated upwardly biasing members 86 and 88 are coupled between the diagonally extending chest support member 72 and the base support member 14 to support the member for movement to a plurality of predetermined diagonal positions.
摘要翻译： 设置有用于在其上支撑使用者12的园艺椅10。 园艺椅10设置有基部支撑构件14和与底座支撑构件的上部对准并联接以用于在其上支撑使用者的下身的座52。 设置有对角延伸的胸部支撑构件72，用于将使用者的胸部12和上身支撑在其上。 一对细长的向上偏置构件86和88联接在对角线延伸的胸部支撑构件72和基部支撑构件14之间，以支撑构件移动到多个预定的对角位置。
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