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    Single molecule identification using selected fluorescence characteristics
    1.
    发明授权
    Single molecule identification using selected fluorescence characteristics 有权
    使用选择的荧光特征进行单分子鉴定

    公开(公告)号：US6049380A

    公开(公告)日：2000-04-11

    申请号：US169025

    申请日：1998-10-09

    申请人： Peter M. Goodwin ,  James H. Jett ,  Richard A. Keller ,  Alan K. Van Orden ,  Nicholas P. Machara

    发明人： Peter M. Goodwin ,  James H. Jett ,  Richard A. Keller ,  Alan K. Van Orden ,  Nicholas P. Machara

    IPC分类号： G01N21/64 ,  F21V9/16 ,  G01J3/30

    CPC分类号： G01N21/6428 ,  G01N21/6408

    摘要： Single fluorescent molecules in a flowing sample stream are distinguished and identified using only a single laser excitation wavelength. A sample stream is formed containing a dilute mixture of single molecule fluorophores, wherein each one of the fluorophores is serially ordered in the sample stream. The sample stream is illuminated with s single excitation wavelength laser effective to excite each fluorophore one at a time. Fluorescence emission photons from each said fluorophore are detected. A burst size is determined for each fluorophore to identify each fluorophore. A pulsed laser may be used, where burst size and an intra-burst fluorescence decay rate for each fluorophore are determined simultaneously from the detected fluorescence emission photons. The burst size and the decay rate are correlated to identify each fluorophore.

    摘要翻译： 流动样品流中的单个荧光分子仅使用单个激光激发波长来识别和识别。 形成包含单分子荧光团的稀混合物的样品流，其中每个荧光团在样品流中连续排列。 用单个激发波长激光器照射样品流，有效地一次激发每个荧光团。 检测来自每个所述荧光团的荧光发射光子。 确定每个荧光团的突发尺寸以识别每个荧光团。 可以使用脉冲激光，其中从检测到的荧光发射光子同时测定每个荧光团的突发尺寸和爆发内荧光衰减速率。 脉冲串大小和衰减速率相关，以识别每个荧光团。

    MECHANICAL WALLET
    5.
    发明申请
    MECHANICAL WALLET 有权

    公开(公告)号：US20220248822A1

    公开(公告)日：2022-08-11

    申请号：US17728832

    申请日：2022-04-25

    申请人： Peter M. Goodwin

    发明人： Peter M. Goodwin ,  George Brooks ,  Cody Hutchins ,  Salmon Nortje ,  Graham Harrison

    IPC分类号： A45C11/18 ,  A45C13/18 ,  A45C13/10 ,  A45C13/00

    摘要： A mechanical wallet or cardholder can be opened using one hand by sliding a top or second plate along rails parallel to a bottom or first plate. A card arm forces cards in the cardholder (i.e., located between the first and second plates) out a second end of the cardholder in a fanned or stepped fashion. A magnet in the card arm and in a first end of the frame (opposite the second end of the cardholder and frame) cooperate to return and retain the card arm and first plate in the closed position. A card lock at the second end of the frame retains cards in the cardholder when the cardholder is in the closed position and allows the cards to be pushed from the second end of the cardholder by the card arm when the second plate is moved to the open position.

    HYBRID RING
    6.
    发明公开
    HYBRID RING 审中-公开

    公开(公告)号：US20230145584A1

    公开(公告)日：2023-05-11

    申请号：US18092381

    申请日：2023-01-02

    申请人： Peter M. Goodwin

    发明人： Peter M. Goodwin

    IPC分类号： A44C9/00

    CPC分类号： A44C9/0007

    摘要： A ring for wearing by a user includes a rigid outer annular body and a flexible inner annular body. In one embodiment, the outer annular body is a rigid material formed form a process other than injection molding, and the inner annular body is flexible and formed form an injection molded process. The outer annular body is attached to the inner annular body. The inner annular body may be machined to curve from longitudinal ends of the inner annular body to an inner surface of the inner annular body after the inner annular body is joined to the outer annular body in order to provide a comfort fit. Alternatively, the inner annular body may be molded with the comfort fit curvature. In one embodiment, the outer annular body has at least one strain relief recess in an inner surface thereof, and the inner annular body fills said strain relief recess.

    Reduction of diffusional defocusing in hydrodynamically focused flows
    7.
    发明授权
    Reduction of diffusional defocusing in hydrodynamically focused flows 失效
    减少流体动力学聚焦流中的扩散散焦

    公开(公告)号：US5799682A

    公开(公告)日：1998-09-01

    申请号：US758738

    申请日：1996-12-06

    申请人： Rhett L. Affleck ,  James N. Demas ,  Peter M. Goodwin ,  Richard Keller ,  Ming Wu

    发明人： Rhett L. Affleck ,  James N. Demas ,  Peter M. Goodwin ,  Richard Keller ,  Ming Wu

    IPC分类号： G01N15/14 ,  F15C1/20

    CPC分类号： G01N15/1404 ,  Y10T137/0396 ,  Y10T137/2076 ,  Y10T137/2196

    摘要： An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.

    摘要翻译： 具有相对较低分子量和相应的高扩散系数的具有第一分子的分析物流体流减少了分析物流体流的扩散散焦。 第一分子的分析物流体流与具有相对低的扩散系数的第二分子和具有与第一分子缔合有关的结合常数的第二分子缔合。 维持聚焦的分析物流体流，因为相关联的第一和第二分子的组合分子量有效地使第一分子离开分析物流体流的扩散最小化。

    Mechanical wallet
    8.
    发明授权
    Mechanical wallet 有权

    公开(公告)号：US11903468B2

    公开(公告)日：2024-02-20

    申请号：US17728832

    申请日：2022-04-25

    申请人： Peter M. Goodwin

    发明人： Peter M. Goodwin ,  George Brooks ,  Cody Hutchins ,  Salmon Nortje ,  Graham Harrison

    IPC分类号： A45C11/18 ,  A45C13/18 ,  A45C13/10 ,  A45C13/00

    CPC分类号： A45C11/182 ,  A45C13/005 ,  A45C13/1069 ,  A45C13/185

    摘要： A mechanical wallet or cardholder can be opened using one hand by sliding a top or second plate along rails parallel to a bottom or first plate. A card arm forces cards in the cardholder (i.e., located between the first and second plates) out a second end of the cardholder in a fanned or stepped fashion. A magnet in the card arm and in a first end of the frame (opposite the second end of the cardholder and frame) cooperate to return and retain the card arm and first plate in the closed position. A card lock at the second end of the frame retains cards in the cardholder when the cardholder is in the closed position and allows the cards to be pushed from the second end of the cardholder by the card arm when the second plate is moved to the open position.