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公开(公告)号:US4829053A
公开(公告)日:1989-05-09
申请号:US80265
申请日:1987-07-31
申请人: Peter Raddatz , Joachim Gante , Claus J. Schmitges , Klaus Otto Minck , Johannes Sombroek , Gunter Holzemann
发明人: Peter Raddatz , Joachim Gante , Claus J. Schmitges , Klaus Otto Minck , Johannes Sombroek , Gunter Holzemann
IPC分类号: A61K38/00 , A61K31/41 , A61K31/425 , A61K31/426 , A61P5/38 , A61P9/00 , A61P9/12 , C07D257/04 , C07D257/06 , C07D277/20 , C07D277/40 , C07D277/46 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K14/81
CPC分类号: C07K5/0227 , Y10S530/86
摘要: New aminoacid derivatives of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--NR.sup.6 --(CHR.sup.7).sub.s --D Iwherein X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, R.sup.6, R.sup.7, D, n and s have the meanings defined herein and their salts, inhibit the activity of human plasma renin.
摘要翻译: 式I XZ-NR2-CHR3-CR4-(CHR5)n-CO-E-NR6-(CHR7)sD I的新的氨基酸衍生物其中X,Z,R2,R3,R4,R5,E,R6,R7, D,n和s具有本文定义的含义及其盐,抑制人血浆肾素的活性。
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公开(公告)号:US5215966A
公开(公告)日:1993-06-01
申请号:US126060
申请日:1987-11-27
申请人: Gunter Holzemann , Peter Raddatz , Claus J. Schmitges , Klaus Otto Minck , Alfred Jonczyk , Johannes Sombroek , Joachim Gante
发明人: Gunter Holzemann , Peter Raddatz , Claus J. Schmitges , Klaus Otto Minck , Alfred Jonczyk , Johannes Sombroek , Joachim Gante
IPC分类号: C07K14/81 , A61K38/00 , A61P9/12 , C07C67/00 , C07C231/00 , C07C237/12 , C07C237/22 , C07C239/00 , C07C279/14 , C07C311/00 , C07D401/12 , C07K1/02 , C07K1/113 , C07K1/12 , C07K5/02 , C07K5/06 , C07K5/08
CPC分类号: C07D401/12 , C07K5/0227 , Y10S530/80
摘要: Novel amino acid derivatives of the formula IX--Z--NH--CHR.sup.1 --CO--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--W'--Ywherein X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, W', Y and n have the meanings defined herein and their salts inhibit the activity of human plasma renin.
摘要翻译: 式I XZ-NH-CHR1-CO-NR2-CHR3-CR4-(CHR5)n-CO-E-W'-Y的新型氨基酸衍生物其中X,Z,R1,R2,R3,R4,R5, E,W',Y和n具有本文定义的含义,其盐抑制人血浆肾素的活性。
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公开(公告)号:US5378691A
公开(公告)日:1995-01-03
申请号:US213365
申请日:1994-08-15
CPC分类号: C07K5/0227 , C07K5/0202 , C07K5/0205 , C07K5/0207
摘要: New amino acid derivatives of the formula IR.sup.1 --C.sub.p H.sub.2p --(NH).sub.y --CO--NH--CHR.sup.2 --CO--Z--C.sub.m H.sub.2m --CO--NH--CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--Q--Y Iin which R.sup.1 to R.sup.5, p, y, Z, m, n, E, Q and Y have the meanings defined herein, and the salts thereof, inhibit the activity of human plasma renin.
摘要翻译: 式I R1-CpH2p-(NH)y-CO-NH-CHR2-CO-Z-CmH2m-CO-NH-CHR3-CR4-(CHR5)n-CO-EQ-YI的新氨基酸衍生物,其中R1 至R5,p,y,Z,m,n,E,Q和Y具有本文定义的含义,其盐抑制人血浆肾素的活性。
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公开(公告)号:US5215967A
公开(公告)日:1993-06-01
申请号:US443530
申请日:1989-11-30
IPC分类号: A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07C231/12 , C07C237/12 , C07C237/20 , C07C237/22 , C07C309/12 , C07C309/15 , C07C311/24 , C07C311/29 , C07C311/32 , C07C317/22 , C07C323/18 , C07C323/25 , C07C323/60 , C07C335/06 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K14/81
CPC分类号: C07K5/0227 , C07K5/0205 , C07K5/0207 , Y10S530/80
摘要: New amino acid derivatives of the formulaR.sup.1 --Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.a --CO--E--Q--Ywherein R.sup.1 to R.sup.5, a, Z, E, Q and Y have the meanings defined herein, and salts thereof inhibit the activity of human plasma renin.
摘要翻译: 式R1-Z-NR2-CHR3-CR4-(CHR5)a-CO-EQY的新氨基酸衍生物,其中R1至R5,a,Z,E,Q和Y具有本文定义的含义,其盐抑制 人血浆肾素活性。
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公开(公告)号:US5776937A
公开(公告)日:1998-07-07
申请号:US551743
申请日:1995-11-07
申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer
发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer
IPC分类号: C07D233/36 , A61K31/445 , A61K31/4525 , A61K31/495 , A61K31/496 , A61P7/02 , C07D211/14 , C07D263/18 , C07D263/20 , C07D277/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
CPC分类号: C07D263/20 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要: Compounds of the formula I ##STR1## wherein R.sup.1 and Y have the meanings indicated, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, inflammations, arteriosclerosis and osteolytic disorders.
摘要翻译: 式I的化合物其中R 1和Y具有所示的含义,以及它们的生理上可接受的盐抑制纤维蛋白原与相应受体的结合,并且可用于治疗血栓形成,骨质疏松,肿瘤,中风, 心肌梗塞,炎症,动脉硬化和溶骨性疾病。
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公开(公告)号:US06204280B1
公开(公告)日:2001-03-20
申请号:US09163481
申请日:1998-09-30
申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer , Matthias Wiesner , Claus Fittschen
发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer , Matthias Wiesner , Claus Fittschen
IPC分类号: C07D26324
CPC分类号: C07D413/06 , C07D263/24 , C07D413/10
摘要: Compounds of the formula I wherein R1, R2 and R3 have the meanings defined herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, ischaemias, inflammations, arteriosclerosis and osteolytic disorders.
摘要翻译: 式Ⅰ化合物,其中R 1,R 2和R 3具有本文定义的含义,以及它们的生理上可接受的盐,抑制纤维蛋白原与相应受体的结合,并可用于治疗血栓形成,骨质疏松,肿瘤,中风,心肌梗塞 ,缺血性,炎症性,动脉硬化和溶骨性疾病。
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公开(公告)号:US6028090A
公开(公告)日:2000-02-22
申请号:US964131
申请日:1997-11-06
申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
IPC分类号: A61K31/42 , A61K31/421 , A61K31/44 , A61K31/496 , A61K31/505 , A61P7/02 , A61P9/08 , A61P9/10 , A61P19/10 , A61P29/00 , A61P33/04 , A61P35/00 , A61P43/00 , C07D263/20 , C07D263/24 , C07D413/12 , C07D239/02 , C07D263/08
CPC分类号: C07D263/20 , C07D263/24 , C07D413/12
摘要: Novel oxazolidinone derivatives of the formula I ##STR1## in which R.sup.1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H.sub.2 N--CH.sub.2 --, A.sub.2 N--CH.sub.2 --, H.sub.2 N--C(.dbd.NH)--, H.sub.2 N--C(.dbd.NH)--NH--, H.sub.2 N--C(.dbd.NH)--NH--CH.sub.2 --, HO--NH--C(.dbd.NH)-- or HO--NH--C(.dbd.NH)--NH--,X is O, S, SO, SO.sub.2, --NH-- or --NA--,B is ##STR2## A is alkyl having from 1 to 6 C atoms, R.sup.2 is H, A, Li, Na, K, NH.sub.4 or benzyl,R.sup.3 is H or (CH.sub.2).sub.n --COOR.sup.2,E is, in each case independently of each other, CH or N,Q is O, S or NH,m is 1, 2 or 3, andn is 0, 1, 2 or 3,and physiologically compatible salts thereof are provided, which inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumors.
摘要翻译: 式I的新型恶唑烷酮衍生物,其中R 1是未取代的或被CN,H 2 N-CH 2 - ,A 2 N-CH 2 - ,H 2 N-C(= NH) - ,H 2 N-C(= NH) - NH-,H 2 N-C(= NH)-NH-CH 2 - ,HO-NH-C(= NH) - 或HO-NH-C(= NH)-NH-,X是O,S,SO,SO 2, -NH-或-NA-,B是A是具有1至6个C原子的烷基,R 2是H,A,Li,Na,K,NH 4或苄基,R 3是H或(CH 2)n -COOR 2,E是 在每种情况下彼此独立地为CH或N,Q为O,S或NH,m为1,2或3,n为0,1,2或3,并且其生理上相容的盐被抑制 纤维蛋白原与相应受体的结合,可用于治疗血栓形成,中风,心肌梗死,炎症,动脉硬化,骨质疏松症以及肿瘤。
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公开(公告)号:US5723480A
公开(公告)日:1998-03-03
申请号:US654690
申请日:1996-05-29
申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Guido Melzer , Sabine Bernotat-Danielowski
IPC分类号: A61K31/42 , A61K31/421 , A61K31/44 , A61K31/496 , A61K31/505 , A61P7/02 , A61P9/08 , A61P9/10 , A61P19/10 , A61P29/00 , A61P33/04 , A61P35/00 , A61P43/00 , C07D263/20 , C07D263/24 , C07D413/12 , C07D263/38
CPC分类号: C07D263/20 , C07D263/24 , C07D413/12
摘要: Novel oxazolidinone derivatives of the formula I ##STR1## in which R.sup.1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H.sub.2 N--CH.sub.2 --, A.sub.2 N--CH.sub.2 --, H.sub.2 N--C(.dbd.NH)--, H.sub.2 N--C(.dbd.NH)--NH--, H.sub.2 N--C(.dbd.NH)--NH--CH.sub.2 --, HO--NH--C(.dbd.NH)-- or HO--NH--C(.dbd.NH)--NH--, X is O, S, SO, SO.sub.2, --NH-- or --NA--, B is ##STR2## A is alkyl having from 1 to 6 C atoms, R.sup.2 is H, A, Li, Na, K, NH.sub.4 or benzyl, R.sup.3 is H or (CH.sub.2).sub.n --COOR.sup.2, E is, in each case independently of each other, CH or N, Q is O, S or NH, m is 1, 2 or 3, and n is 0, 1, 2 or 3, and physiologically compatible salts thereof are provided, which inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumors.
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公开(公告)号:US06602876B1
公开(公告)日:2003-08-05
申请号:US08552206
申请日:1995-11-02
申请人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer , Matthias Wiesner , Claus Fittschen
发明人: Joachim Gante , Horst Juraszyk , Peter Raddatz , Hanns Wurziger , Sabine Bernotat-Danielowski , Guido Melzer , Matthias Wiesner , Claus Fittschen
IPC分类号: A61K314166
CPC分类号: C07D413/06 , C07D263/24 , C07D413/10
摘要: Compounds of the formula I wherein R1, R2 and R3 have the meanings defined herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be employed for the treatment of thromboses, osteoporoses, oncoses, apoplexy, cardiac infarct, ischaemias, inflammations, arteriosclerosis and osteolytic disorders.
摘要翻译: 式Ⅰ化合物,其中R 1,R 2和R 3具有本文定义的含义,以及它们的生理上可接受的盐,抑制纤维蛋白原与相应受体的结合,并可用于治疗血栓形成,骨质疏松,肿瘤,中风,心肌梗塞 ,缺血性,炎症性,动脉硬化和溶骨性疾病。
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公开(公告)号:US5532255A
公开(公告)日:1996-07-02
申请号:US234691
申请日:1994-04-29
申请人: Peter Raddatz , Joachim Gante , Horst Juraczyk , Hanns Wurziger , Helmut Prucher , Sabine Bernotat-Danielowski , Guido Melzer
发明人: Peter Raddatz , Joachim Gante , Horst Juraczyk , Hanns Wurziger , Helmut Prucher , Sabine Bernotat-Danielowski , Guido Melzer
IPC分类号: A61K31/415 , A61K31/4166 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/55 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D233/36 , C07D263/00 , C07D263/20 , C07D277/14 , C07D295/00 , C07D401/06 , C07D403/06 , C07D413/06 , C07D419/06 , C07D491/10 , C07D491/107 , C07D498/10
CPC分类号: C07D263/20 , C07D413/06 , C07D491/10
摘要: Compounds of the formula ##STR1## in which R.sup.1, X and Y have the meanings defined herein, and their salts, inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and tumors.
摘要翻译: 其中R1,X和Y具有本文定义的含义的式Ⅰ的化合物及其盐抑制纤维蛋白原与纤维蛋白原受体的结合,可用于治疗血栓形成,中风,心肌梗塞,炎症,动脉硬化 ,骨质疏松症和肿瘤。
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