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公开(公告)号：US20060233744A1
公开(公告)日：2006-10-19
申请号：US11254161
申请日：2005-10-18
申请人： Peter Shultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastmark , Steven Santoro , Zhiwen Zhang
发明人： Peter Shultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastmark , Steven Santoro , Zhiwen Zhang
IPC分类号： A61K38/19 , A61K38/18 , A61K38/17 , C07H21/04 , C12P21/06 , C12P21/02 , C07K14/52 , C07K14/715
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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公开(公告)号：US20070117184A1
公开(公告)日：2007-05-24
申请号：US11583551
申请日：2006-10-18
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C07K14/705 , C07K14/82 , C07K14/54 , C07K14/52 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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3.发明申请Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 有权用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成公开(公告)号：US20050208536A1
公开(公告)日：2005-09-22
申请号：US11009635
申请日：2004-12-10
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/00 , C07K14/47 , C07K14/505 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/67 , C12P13/00 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02 , C12Q1/02 , C12Q1/06 , C12Q1/68 , C07H21/04 , C12N9/22 , C12N15/74
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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公开(公告)号：US20050250183A1
公开(公告)日：2005-11-10
申请号：US11017550
申请日：2004-12-17
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/00 , C07K14/47 , C07K14/505 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/67 , C12P13/00 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02 , C12Q1/02 , C12Q1/06 , C07H21/04 , C12N15/74 , C12P13/20 , C12P19/28
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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5.发明申请Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 有权用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成公开(公告)号：US20060234367A1
公开(公告)日：2006-10-19
申请号：US11254170
申请日：2005-10-18
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N9/22
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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6.发明申请公开(公告)号：US20060063244A1
公开(公告)日：2006-03-23
申请号：US11002387
申请日：2004-12-01
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
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公开(公告)号：US09785858B2
公开(公告)日：2017-10-10
申请号：US12567197
申请日：2009-09-25
申请人： Sascha Seifert , Adrian Barbu , Shaohua Kevin Zhou , David Liu , Johannes Feulner , Martin Huber , Michael Suehling , Alexander Cavallaro , Dorin Comaniciu
发明人： Sascha Seifert , Adrian Barbu , Shaohua Kevin Zhou , David Liu , Johannes Feulner , Martin Huber , Michael Suehling , Alexander Cavallaro , Dorin Comaniciu
CPC分类号： G06K9/4638 , G06K2209/05 , G06T7/11 , G06T7/143 , G06T2207/10081 , G06T2207/20081 , G06T2207/20128 , G06T2207/30048 , G06T2207/30056
摘要： A method and apparatus for hierarchical parsing and semantic navigation of a full or partial body computed tomography CT scan is disclosed. In particular, organs are segmented and anatomic landmarks are detected in a full or partial body CT volume. One or more predetermined slices of the CT volume are detected. A plurality of anatomic landmarks and organ centers are then detected in the CT volume using a discriminative anatomical network, each detected in a portion of the CT volume constrained by at least one of the detected slices. A plurality of organs, such as heart, liver, kidneys, spleen, bladder, and prostate, are detected in a sense of a bounding box and segmented in the CT volume, detection of each organ bounding box constrained by the detected organ centers and anatomic landmarks. Organ segmentation is via a database-guided segmentation method.
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公开(公告)号：US09442883B2
公开(公告)日：2016-09-13
申请号：US13971707
申请日：2013-08-20
申请人： James Liao , Lin Du , David Liu
发明人： James Liao , Lin Du , David Liu
IPC分类号： G06F15/167 , G06F15/173
CPC分类号： G06F15/17331 , G06F17/30073 , G06F17/30861
摘要： A method and apparatus are disclosed herein for retrieving network traffic data. In one embodiment, a networking apparatus comprises a memory; a network device; and a processing unit coupled to the network device and the memory. The processing unit is operable to execute a data engine that performs bulk data transfers from the network device periodically into a data buffer in the memory and translates data received from the network device, based on a mapping definition, into a user defined format for export to one or more applications running on networking apparatus.
摘要翻译： 本文公开了一种用于检索网络业务数据的方法和装置。 在一个实施例中，网络装置包括存储器; 网络设备; 以及耦合到网络设备和存储器的处理单元。 所述处理单元可操作以执行数据引擎，所述数据引擎从所述网络设备周期性地进行批量数据传输到所述存储器中的数据缓冲器中，并且将从所述网络设备接收的数据基于映射定义转换成用户定义的格式以输出到 网络设备上运行的一个或多个应用程序。
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公开(公告)号：US09117259B2
公开(公告)日：2015-08-25
申请号：US13238370
申请日：2011-09-21
申请人： David Liu , Dijia Wu , Shaohua Kevin Zhou , Maria Jimena Costa , Michael Suehling , Christian Tietjen
发明人： David Liu , Dijia Wu , Shaohua Kevin Zhou , Maria Jimena Costa , Michael Suehling , Christian Tietjen
CPC分类号： G06T7/0016 , G06T7/41 , G06T2207/10072 , G06T2207/20012 , G06T2207/20041 , G06T2207/20081 , G06T2207/20104 , G06T2207/30056
摘要： A method and system for automatically detecting liver lesions in medical image data, such as 3D CT images, is disclosed. A liver region is segmented in a 3D image. Liver lesion center candidates are detected in the segmented liver region. Lesion candidates are segmented corresponding to the liver lesion center candidates, and lesions are detected from the segmented lesion candidates using learning based verification.
摘要翻译： 公开了一种用于自动检测医学图像数据中肝脏病变的方法和系统，如3D CT图像。 肝脏区域被分割成3D图像。 肝脏病变中心候选人在分段肝脏区域检测到。 病变候选者对应于肝脏病变中心候选物，并且使用基于学习的验证从分割的病变候选物检测病变。
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公开(公告)号：US08761480B2
公开(公告)日：2014-06-24
申请号：US13229953
申请日：2011-09-12
CPC分类号： G06K9/00 , G06K2209/05 , G06T7/0012 , G06T7/73 , G06T2207/10028 , G06T2207/10081 , G06T2207/20044 , G06T2207/20081 , G06T2207/30101 , G06T2207/30172 , G06T2207/30204
摘要： The present invention provides a method and system for vascular landmark detection in CT volumes. A CT volume is received and an initial position of a plurality of vascular landmarks is detected. The initial position of each of the plurality of vascular landmarks is then adjusted in order to position each vascular landmark inside a vessel lumen. A new position of each of the plurality of vascular landmarks representing the adjusted initial positions is output.
摘要翻译： 本发明提供了CT体积中血管标志物检测的方法和系统。 接收CT体积并检测多个血管界标的初始位置。 然后调整多个血管标志中的每一个的初始位置，以便将血管标记位于血管内腔内。 输出表示调整后的初始位置的多个血管界标中的每一个的新位置。
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