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公开(公告)号：US20060233744A1
公开(公告)日：2006-10-19
申请号：US11254161
申请日：2005-10-18
申请人： Peter Shultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastmark , Steven Santoro , Zhiwen Zhang
发明人： Peter Shultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastmark , Steven Santoro , Zhiwen Zhang
IPC分类号： A61K38/19 , A61K38/18 , A61K38/17 , C07H21/04 , C12P21/06 , C12P21/02 , C07K14/52 , C07K14/715
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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公开(公告)号：US20070117184A1
公开(公告)日：2007-05-24
申请号：US11583551
申请日：2006-10-18
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C07K14/705 , C07K14/82 , C07K14/54 , C07K14/52 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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3.发明申请Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 有权用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成公开(公告)号：US20050208536A1
公开(公告)日：2005-09-22
申请号：US11009635
申请日：2004-12-10
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/00 , C07K14/47 , C07K14/505 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/67 , C12P13/00 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02 , C12Q1/02 , C12Q1/06 , C12Q1/68 , C07H21/04 , C12N9/22 , C12N15/74
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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公开(公告)号：US20050250183A1
公开(公告)日：2005-11-10
申请号：US11017550
申请日：2004-12-17
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/00 , C07K14/00 , C07K14/47 , C07K14/505 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/67 , C12P13/00 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02 , C12Q1/02 , C12Q1/06 , C07H21/04 , C12N15/74 , C12P13/20 , C12P19/28
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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5.发明申请Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 有权用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成公开(公告)号：US20060234367A1
公开(公告)日：2006-10-19
申请号：US11254170
申请日：2005-10-18
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
IPC分类号： C12N9/22
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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6.发明申请公开(公告)号：US20060063244A1
公开(公告)日：2006-03-23
申请号：US11002387
申请日：2004-12-01
申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
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公开(公告)号：US07915025B2
公开(公告)日：2011-03-29
申请号：US11800455
申请日：2007-05-04
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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公开(公告)号：US07368275B2
公开(公告)日：2008-05-06
申请号：US11254161
申请日：2005-10-18
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Steven William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason W. Chin , David R. Liu , Thomas J. Magliery , Eric Meggers , Ryan Aaron Mehl , Miro Pastrnak , Steven William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
摘要翻译： 本发明提供用于体内掺入非天然氨基酸的方法和组合物。 还提供了包含具有非天然氨基酸的蛋白质的组合物。
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9.发明授权公开(公告)号：US07083970B2
公开(公告)日：2006-08-01
申请号：US10126931
申请日：2002-04-19
申请人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
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10.发明授权Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs 有权用于生产正交tRNA-氨酰基tRNA合成酶对的方法和组成公开(公告)号：US07713721B2
公开(公告)日：2010-05-11
申请号：US11002387
申请日：2004-12-01
申请人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
发明人： Peter G. Schultz , Lei Wang , John Christopher Anderson , Jason Chin , David R. Liu , Thomas J. Magliery , Eric L. Meggers , Ryan Aaron Mehl , Miro Pastrnak , Stephen William Santoro , Zhiwen Zhang
CPC分类号： C12P21/00 , C07K14/00 , C07K14/505 , C12N9/93 , C12N15/67 , C12P13/00 , C12P13/005 , C12P13/04 , C12P13/22 , C12P19/26 , C12P21/02
摘要： This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
摘要翻译： 本发明提供了用于产生蛋白质生物合成机理组分的组合物和方法，包括正交的tRNA，正交氨酰-tRNA合成酶和正向对的tRNA /合成酶。 还提供了用于识别正交对的方法。 这些组分可用于在体内将非天然氨基酸掺入蛋白质。
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