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1.发明申请INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO 审中-公开HEDGEHOG信号通道，组合物和相关用途的抑制剂公开(公告)号：US20100273818A1
公开(公告)日：2010-10-28
申请号：US12652134
申请日：2010-01-05
IPC分类号： A61K31/438 , A61P35/00 , C12N5/02 , A61P15/16
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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2.发明授权公开(公告)号：US06214794B1
公开(公告)日：2001-04-10
申请号：US08729743
申请日：1996-10-07
IPC分类号： C07K14475
CPC分类号： G01N33/92 , A61K38/00 , C07K14/43581 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a Gly↓Cys Phe site recognized by the autoproteolytic domain in the native protein. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. Also provided are methods of use of the N and C fragments.
摘要翻译： 本发明提供两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或分别在由Gly↓Cys Phe位点识别的Gly↓Cys Phe位点上特异性切割后产生的N-末端和C-末端片段 天然蛋白中的自体蛋白水解结构域。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 还提供了使用N和C片段的方法。
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公开(公告)号：US08076073B2
公开(公告)日：2011-12-13
申请号：US10442435
申请日：2003-05-20
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US08071733B2
公开(公告)日：2011-12-06
申请号：US12790611
申请日：2010-05-28
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。
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公开(公告)号：US07741451B2
公开(公告)日：2010-06-22
申请号：US11804733
申请日：2007-05-18
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。
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6.发明授权Inhibitors of hedgehog signaling pathways, compositions and uses related thereto 有权刺猬蛋白信号通路抑制剂，组合物和与之相关的用途公开(公告)号：US07291626B1
公开(公告)日：2007-11-06
申请号：US09708964
申请日：2000-11-08
IPC分类号： A61K31/4355
CPC分类号： A61K31/4355 , A61K31/00 , A61K31/435 , A61K31/438 , A61K31/58
摘要： The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule.
摘要翻译： 本发明使得可用性测定和试剂抑制由刺猬蛋白质产生的旁分泌和/或自分泌信号或异常激活刺猬蛋白信号转导途径，例如涉及使用甾族生物碱或其它小分子。
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公开(公告)号：US06911528B1
公开(公告)日：2005-06-28
申请号：US09562914
申请日：2000-05-02
IPC分类号： A61K38/00 , C07K14/435 , C07K14/46 , C07K14/47 , C12N15/62 , G01N33/68 , G01N33/92 , C07K14/475
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G↓CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译： 本发明提供两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或分别在由G↓CF位点识别的G↓CF位点上特异性切割后衍生的N-末端和C-末端片段 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。
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公开(公告)号：US06288048B1
公开(公告)日：2001-09-11
申请号：US09250785
申请日：1999-02-12
IPC分类号： A61K3158
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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9.发明授权Method of detection using antibodies that specifically bind hedgehog-derived polypeptides 失效使用特异性结合刺猬蛋白衍生多肽的抗体的检测方法公开(公告)号：US08362216B2
公开(公告)日：2013-01-29
申请号：US13252034
申请日：2011-10-03
CPC分类号： G01N33/5008 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5011 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的N和C片段，或N末端和C末端片段，其是在特异性切割后在自身蛋白水解结构域识别的G'CF位点衍生的 天然蛋白质 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。
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公开(公告)号：US20090186029A1
公开(公告)日：2009-07-23
申请号：US11804733
申请日：2007-05-18
IPC分类号： A61K39/395 , C07K16/00 , A61P43/00
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。
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