公开(公告)号：US20230190924A1

公开(公告)日：2023-06-22

申请号：US16617860

申请日：2017-12-06

申请人： HOYU CO., LTD.

发明人： Kayoko Matsunaga ,  Akiko Yagami ,  Fumiaki Ohno ,  Yuji Aoki

IPC分类号： A61K39/35 ,  C07K14/465 ,  A61P37/08 ,  G01N33/68

CPC分类号： A61K39/35 ,  C07K14/465 ,  A61P37/08 ,  G01N33/6854 ,  G01N2333/465 ,  G01N2800/24

摘要： The present invention provides novel antigens of an allergy to egg, methods and kits for diagnosing an allergy to egg, pharmaceutical compositions comprising such an antigen, eggs or processed products of egg in which such an antigen is eliminated or reduced, birds that deliver such eggs or are born from such eggs, a method for producing processed products of egg in which such an antigen is eliminated or reduced, and a tester for determining the presence or absence of an egg antigen in an object of interest. The present invention also relates to polypeptides comprising an epitope of an antigen, kits, compositions and methods for diagnosing an allergy, comprising such a polypeptide, pharmaceutical compositions comprising such a polypeptide, and raw materials or processed products in which an antigen comprising such a polypeptide is eliminated or reduced. The present invention further relates to a tester for determining the presence or absence of an antigen in an object of interest.

公开(公告)号：US20110002941A1

公开(公告)日：2011-01-06

申请号：US12790611

申请日：2010-05-28

申请人： PHILIP A. BEACHY ,  JEFFREY A. PORTER

发明人： PHILIP A. BEACHY ,  JEFFREY A. PORTER

IPC分类号： A61K39/395 ,  C07K14/435 ,  C07K16/18 ,  C40B40/10

CPC分类号： G01N33/5005 ,  A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C12N15/62 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5058 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/43573 ,  G01N2333/4603 ,  G01N2333/4606 ,  G01N2333/465 ,  G01N2333/47 ,  G01N2500/10

摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

公开(公告)号：US20040018979A1

公开(公告)日：2004-01-29

申请号：US10460594

申请日：2003-06-11

发明人： Philip A. Beachy ,  Jeffrey A. Porter

IPC分类号： A61K038/17 ,  C07K014/47

CPC分类号： G01N33/5005 ,  A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C12N15/62 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5058 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/43573 ,  G01N2333/4603 ,  G01N2333/4606 ,  G01N2333/465 ,  G01N2333/47 ,  G01N2500/10

摘要： The present invention provides two novel polypeptides, referred to as the nullNnull and nullCnull fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a GnullCF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

摘要翻译： 本发明提供两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或分别在识别的G <↓> CF位点的特异性切割后产生的N-末端和C-末端片段 通过天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

公开(公告)号：US20170299579A1

公开(公告)日：2017-10-19

申请号：US15337155

申请日：2016-10-28

申请人： Joel Steven Goldberg

发明人： Joel Steven Goldberg

IPC分类号： G01N33/50 ,  G01N33/483 ,  G01N33/94

CPC分类号： G01N33/5088 ,  G01N33/4833 ,  G01N33/94 ,  G01N2333/465

摘要： The vitelline membrane of an egg is a novel, inexpensive and useful model of the human blood brain barrier (BBB). FD&C Blue #1, FD&C Red #40, FD&C Red #3, quinine and fluorescein do not cross the vitelline membrane and do not cross the human BBB. Ethanol, diethyl ether, 2-chloroprocaine and acetaminophen, cross the vitelline membrane and are known to cross the human BBB. Using the vitelline membrane, as model of the human BBB, may decrease the time and cost of discovering lead drugs for the treatment of central nervous system diseases.

公开(公告)号：US20130203871A1

公开(公告)日：2013-08-08

申请号：US13837941

申请日：2013-03-15

申请人： GILLES R.G. MONIF

发明人： GILLES R.G. MONIF

IPC分类号： G01N33/569

CPC分类号： G01N33/5695 ,  G01N2333/35 ,  G01N2333/465

摘要： The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to Mycobacterium avium subspecies paratuberculosis (Map) and related genomic variants and upon the ability of two distinct Map ELISA tests to sequentially or in parallel determine prior and current Map infection and evidence of active mycobacterium replication. Interpretation of the test results are integrated into sequential directives designed to enhance productive retention of infected animals as well as identify animals not previously infected. The sequential utilization of the data guidelines is developed to minimize the adverse economic impact of these infections.

摘要翻译： 本发明是基于发明人对由于鸟分枝杆菌亚型副结核病（Map）和相关基因组变体引起的牛感染的自然史的分析的群体管理模式，并且基于两种不同的Map ELISA测试顺序或并行确定先前和 目前的地图感染和活跃的分枝杆菌复制的证据。 测试结果的解释被整合到旨在增强感染动物的生产性保留以及识别以前未被感染的动物的顺序指令中。 开发数据指南的顺序利用是为了尽量减少这些感染的不利经济影响。

公开(公告)号：US08071733B2

公开(公告)日：2011-12-06

申请号：US12790611

申请日：2010-05-28

申请人： Philip A. Beachy ,  Jeffrey A. Porter ,  Randall T. Moon

发明人： Philip A. Beachy ,  Jeffrey A. Porter ,  Randall T. Moon

IPC分类号： C07K16/00 ,  C07K16/18

CPC分类号： G01N33/5005 ,  A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C12N15/62 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5058 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/43573 ,  G01N2333/4603 ,  G01N2333/4606 ,  G01N2333/465 ,  G01N2333/47 ,  G01N2500/10

摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

公开(公告)号：US20100159615A1

公开(公告)日：2010-06-24

申请号：US12521451

申请日：2007-12-27

申请人： Haruo Matsuda ,  Fujiko Kanezawa ,  Hiroyuki Kubo ,  Norihisa Nishimichi ,  Masayoshi Aosasa

发明人： Haruo Matsuda ,  Fujiko Kanezawa ,  Hiroyuki Kubo ,  Norihisa Nishimichi ,  Masayoshi Aosasa

IPC分类号： G01N33/53

CPC分类号： G01N33/6857 ,  G01N2333/465

摘要： An object of the present invention is to provide an immunological detection method using an avian antibody, comprising suppressing a non-specific reaction caused by using an avian antibody. According to the present invention, there is provided an immunological detection method comprising detecting a target substance in a sample from a mammal using an avian antibody, characterized in that a non-specific reaction induced by the use of the avian antibody is suppressed.

摘要翻译： 本发明的目的是提供使用禽类抗体的免疫学检测方法，其包括抑制由使用禽类抗体引起的非特异性反应。 根据本发明，提供一种免疫学检测方法，其包括使用禽类抗体检测来自哺乳动物的样品中的目标物质，其特征在于抑制由使用禽抗体诱导的非特异性反应。

公开(公告)号：US07741451B2

公开(公告)日：2010-06-22

申请号：US11804733

申请日：2007-05-18

申请人： Philip A. Beachy ,  Jeffrey A. Porter

发明人： Philip A. Beachy ,  Jeffrey A. Porter

IPC分类号： C07K16/00 ,  C07K16/18

CPC分类号： G01N33/5005 ,  A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/03 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C12N15/62 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5058 ,  G01N33/68 ,  G01N33/92 ,  G01N2333/43573 ,  G01N2333/4603 ,  G01N2333/4606 ,  G01N2333/465 ,  G01N2333/47 ,  G01N2500/10

摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

摘要翻译： 本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生 天然蛋白质中的自体蛋白水解结构域。 还包括固醇修饰的刺猬蛋白多肽及其功能片段。 描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

公开(公告)号：US20180193449A1

公开(公告)日：2018-07-12

申请号：US15576080

申请日：2016-05-25

申请人： HOYU CO., LTD.

发明人： Kayoko Matsunaga ,  Akiko Yagami ,  Yasuto Kondo ,  Kazuhiro Hara ,  Masashi Nakamura ,  Yuji Aoki

IPC分类号： A61K39/35 ,  A23L15/00 ,  G01N33/53 ,  C07K16/18 ,  C07K14/465

CPC分类号： A61K39/35 ,  A23L15/00 ,  A23V2002/00 ,  C07K14/465 ,  C07K16/18 ,  G01N33/53 ,  G01N2333/465

摘要： The present invention provides novel antigens of an allergy to a quail egg, methods and kits for diagnosing an allergy to a quail egg, pharmaceutical compositions comprising such an antigen, and quail eggs or processed products of quail egg which are devoid of such an antigen.

公开(公告)号：US09417252B2

公开(公告)日：2016-08-16

申请号：US14735286

申请日：2015-06-10

申请人： UNIVERSITA' DEGLI STUDI DI CAMERINO

发明人： Stefano Pesaro ,  Giacomo Rossi

IPC分类号： G01N31/00 ,  G01N33/53 ,  G01N33/92

CPC分类号： G01N33/92 ,  G01N2333/465 ,  G01N2405/10 ,  G01N2800/06

摘要： A ganglioside or a mixture of gangliosides, isolated from the peripheral and central nervous system of a bird, in particular a parrot, their use for the preparation of a medicament, methods for the diagnosis of Proventricular Dilatation Disease and diagnostic kits thereof, are disclosed.