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1.发明授权Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response 失效脂质介导的多核苷酸施用以递送生物活性肽并诱导细胞免疫应答公开(公告)号：US07250404B2
公开(公告)日：2007-07-31
申请号：US10202858
申请日：2002-07-26
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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公开(公告)号：US06413942B1
公开(公告)日：2002-07-02
申请号：US09449923
申请日：1999-12-02
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61N4304
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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公开(公告)号：US5703055A
公开(公告)日：1997-12-30
申请号：US187630
申请日：1994-01-26
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , A61K39/00 , A61K39/395 , C12P21/06
CPC分类号： C07K14/005 , A61K48/00 , A61K9/1272 , C07K14/61 , C12N15/87 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12Y113/12007 , C12N2740/16122
摘要： A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy. In particular, a method is disclosed for the generation of detectable antibodies by the direct administration to a tissue in a mammal a DNA sequence encoding a immunogen where the DNA is complexed to a cationic lipid.
摘要翻译： 公开了一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，其包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并发挥治疗效果 在脊椎动物上。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。 具体地，公开了通过直接向哺乳动物的组织施用编码免疫原的DNA序列产生可检测抗体的方法，其中DNA与阳离子脂质复合。
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4.发明授权Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected 失效脂质介导的多核苷酸给药以减少受试者感染的可能性公开(公告)号：US06867195B1
公开(公告)日：2005-03-15
申请号：US08486533
申请日：1995-06-07
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , A01N43/04 , A61K31/70
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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5.发明授权Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human 失效外源多核苷酸序列在脊椎动物，哺乳动物，鱼类，鸟类或人类中的表达公开(公告)号：US06673776B1
公开(公告)日：2004-01-06
申请号：US08481932
申请日：1995-06-07
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A01N4304
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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6.发明授权Induction of a protective immune response in a mammal by injecting a DNA sequence 失效通过注射DNA序列诱导哺乳动物的保护性免疫应答公开(公告)号：US06214804B1
公开(公告)日：2001-04-10
申请号：US08481919
申请日：1995-06-07
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K4800
CPC分类号： A61K9/1272 , A61K48/00 , C07K14/005 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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公开(公告)号：US06710035B2
公开(公告)日：2004-03-23
申请号：US09452872
申请日：1999-12-02
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K3170
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译： 一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果 脊椎动物。 该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因 治疗。
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公开(公告)号：US5580859A
公开(公告)日：1996-12-03
申请号：US215405
申请日：1994-03-18
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , A01N43/04 , A61K31/70 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K48/00 , A61K9/1272 , C07K14/61 , C12N15/87 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12Y113/12007 , C12N2740/16122
摘要： Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from association with transfection-facilitating proteins, viral particles, liposomal formulations, charged lipids and calcium phosphate precipitating agents.
摘要翻译： 包含DNA和RNA分子的多核苷酸序列可以例如通过注射直接施用于组织如肌肉，并以蛋白质，多肽或多肽表达。 多核苷酸可以包含在脂质体内，或多核苷酸可以与转染促进蛋白质，病毒颗粒，脂质体制剂，带电脂质和磷酸钙沉淀剂无关。
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9.发明授权Induction of a protective immune response in a mammal by injecting a DNA sequence 失效通过注射DNA序列诱导哺乳动物的保护性免疫应答
公开(公告)号：US5589466A
公开(公告)日：1996-12-31
申请号：US380131
申请日：1995-01-26
IPC分类号： A61K9/127 , A61K48/00 , C07K14/16 , C07K14/61 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/78 , C12N15/87 , C12N15/00
CPC分类号： C07K14/005 , A61K48/00 , A61K9/1272 , C07K14/61 , C12N15/87 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12Y113/12007 , C12N2740/16122
摘要： A method for delivering an isolated polynucleotide such as DNA or RNA, to the interior of a cell in a mammal comprising the injection of an isolated polynucleotide into a muscle of the mammal where the polynucleotide is taken up by the cells of the muscle and exerts a therapeutic effect on the mammal. The method can be used to deliver a therapeutic polypeptide to the cells of the mammal, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the mammal or to provide transitory gene therapy.
摘要翻译： 用于将分离的多核苷酸（例如DNA或RNA）递送到哺乳动物细胞内部的方法，包括将分离的多核苷酸注射到哺乳动物的肌肉中，其中所述多核苷酸被肌肉的细胞吸收，并施加 对哺乳动物的治疗作用。 该方法可用于向哺乳动物的细胞递送治疗性多肽，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至哺乳动物的细胞或提供短暂的基因治疗 。
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公开(公告)号：US20090324551A1
公开(公告)日：2009-12-31
申请号：US12064529
申请日：2006-08-21
申请人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
发明人： Dennis A. Carson , Kenji Takabayshi , Suzanne Grimshaw , Howard B. Cottam , Michael Chan , Christina C.N. Wu
IPC分类号： A61K45/00 , C07D473/00 , A61K31/522 , C12N1/20 , C12N7/00 , A61P35/00
CPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
摘要翻译： 本发明提供了TLR激动剂缀合物（化合物）和组合物，以及使用它们的方法。 本发明的化合物是合成免疫刺激剂的广谱，持久和无毒组合，其可用于激活哺乳动物，优选人的免疫系统，并且可以帮助将药效团引导至受体内的受体 靶细胞的内体，并增强由药效团诱导的信号转导。
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