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    Sample collection and testing system
    1.
    发明授权
    Sample collection and testing system 有权
    样本收集和检测系统

    公开(公告)号：US06924498B2

    公开(公告)日：2005-08-02

    申请号：US10861299

    申请日：2004-06-04

    申请人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    发明人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC分类号： G01N33/50 ,  G01N21/76 ,  G01N21/78 ,  G01N33/02 ,  G01N15/06

    CPC分类号： G01N21/76

    摘要： Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or a process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, oxidation reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis. The method further comprises a mechanism for storing data, evaluating data, graphing data, and determining conformance to established criteria.

    摘要翻译： 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其他参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置 ，电导率，氧化还原电位，溶解气体，特定离子和微生物数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。 该方法还包括用于存储数据，评估数据，绘制数据以及确定与已建立标准的一致性的机制。

    SAMPLE COLLECTION AND TESTING SYSTEM
    2.
    发明申请
    SAMPLE COLLECTION AND TESTING SYSTEM 有权
    样品收集和测试系统

    公开(公告)号：US20080272283A1

    公开(公告)日：2008-11-06

    申请号：US12135934

    申请日：2008-06-09

    申请人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    发明人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC分类号： H01J1/56

    CPC分类号： G01N21/8507 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2001/028

    摘要： Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.

    摘要翻译： 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其它参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置， 电导率，还原电位，溶解气体，特定离子和微生物计数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。

    Sample collection and testing system having a displacement member causing reagent to come into contact with a sample collection surface
    3.
    发明授权
    Sample collection and testing system having a displacement member causing reagent to come into contact with a sample collection surface 有权
    样品收集和测试系统具有使得试剂与样品收集表面接触的位移元件

    公开(公告)号：US07399984B2

    公开(公告)日：2008-07-15

    申请号：US11354413

    申请日：2006-02-14

    申请人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    发明人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC分类号： G01N15/06

    CPC分类号： G01N21/8507 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2001/028

    摘要： Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.

    摘要翻译： 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其它参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置， 电导率，还原电位，溶解气体，特定离子和微生物计数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。

    Sample collection and testing system including a rotatable shaft with a helical guiding member to translate longitudinal motion of a slidable shaft into rotational motion
    4.
    发明授权
    Sample collection and testing system including a rotatable shaft with a helical guiding member to translate longitudinal motion of a slidable shaft into rotational motion 有权
    样品收集和测试系统包括具有螺旋引导构件的可旋转轴，以将可滑动轴的纵向运动转化为旋转运动

    公开(公告)号：US07544961B2

    公开(公告)日：2009-06-09

    申请号：US12135934

    申请日：2008-06-09

    申请人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    发明人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC分类号： G01N15/06

    CPC分类号： G01N21/8507 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2001/028

    摘要： Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.

    摘要翻译： 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其它参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置， 电导率，还原电位，溶解气体，特定离子和微生物计数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。

    Sample collection and bioluminescent sample testing system
    5.
    发明授权
    Sample collection and bioluminescent sample testing system 有权
    样品采集和生物发光样品测试系统

    公开(公告)号：US07030403B2

    公开(公告)日：2006-04-18

    申请号：US10313941

    申请日：2002-12-05

    申请人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    发明人： Philip T. Feldsine ,  Tim A. Kelly ,  Jim Christensen ,  Joseph B. Di Carlo ,  Mark Andersen ,  Anita Kressner

    IPC分类号： G01N15/06

    CPC分类号： G01N21/8507 ,  G01N21/645 ,  G01N21/76 ,  G01N21/763 ,  G01N2001/028

    摘要： Methods and apparatus for evaluating the quality of a sample of a product, an ingredient, an environment or process by measuring multiple parameters thereof, including light emitted from a reacting sample containing ATP, ADP, alkaline phosphatase or other parameters such as pH, temperature, conductivity, reduction potential, dissolved gases, specific ions, and microbiological count. The apparatus comprises an integrated sample testing device used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The apparatus also comprises an instrument having a photon detection assembly for use with the sample testing device. The instrument can also comprise one or more sensing probes and a communication port to facilitate data collection, transfer and analysis.

    摘要翻译： 通过测量其多个参数，包括从含有ATP，ADP，碱性磷酸酶或其它参数如pH，温度的反应样品发射的光来评价产品，成分，环境或过程的样品的质量的方法和装置， 电导率，还原电位，溶解气体，特定离子和微生物计数。 该装置包括用于收集样品，混合试剂，使样品反应并将其收集在测量室中的集成样品测试装置。 该装置还包括具有用于样品测试装置的光子检测组件的仪器。 仪器还可以包括一个或多个感测探头和通信端口，以便于数据收集，传输和分析。

    System and method for determining copies-per-unit-volume using PCR and flow control of droplets
    8.
    发明授权
    System and method for determining copies-per-unit-volume using PCR and flow control of droplets 有权
    使用PCR和液滴的流量控制来确定每单位体积份数的系统和方法

    公开(公告)号：US09322055B2

    公开(公告)日：2016-04-26

    申请号：US14009304

    申请日：2012-03-30

    申请人： Gordon A. Janaway ,  Mark Andersen ,  Kornelija Zgonc ,  Michael Pallas ,  Marcin Sikora ,  Casey McFarland ,  Ferrier N. Le ,  Haopeng Wang ,  Jian Gong ,  Gothami Padmabandu

    发明人： Gordon A. Janaway ,  Mark Andersen ,  Kornelija Zgonc ,  Michael Pallas ,  Marcin Sikora ,  Casey McFarland ,  Ferrier N. Le ,  Haopeng Wang ,  Jian Gong ,  Gothami Padmabandu

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N21/6486 ,  C12Q2537/16 ,  C12Q2563/143 ,  C12Q2563/159 ,  C12Q2565/626

    摘要： Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.

    摘要翻译： 提供了用于定量样品中靶核酸的方法和系统。 该方法包括形成多个离散的样本部分。 多个离散样品部分中的每一个包含样品的一部分和反应混合物。 该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。 至少一个离散加工的样品部分含有核酸扩增反应产物。 从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。 该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。 估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

    Methods and kits for methylation detection
    9.
    发明申请
    Methods and kits for methylation detection 审中-公开
    用于甲基化检测的方法和试剂盒

    公开(公告)号：US20060234252A1

    公开(公告)日：2006-10-19

    申请号：US11173569

    申请日：2005-07-01

    申请人： Mark Andersen

    发明人： Mark Andersen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/683 ,  C12Q2523/125 ,  C12Q2521/501

    摘要： Methods for determining the methylation state of at least one target nucleotide that employ a reaction catalyzed by a structure-specific nuclease, typically coupled with a ligation reaction are disclosed. By detecting the cleaved flap, a ligation product, a ligation product surrogate, a hybridization complex, or combinations thereof, one can infer the degree to which the corresponding target nucleotide is methylated. Certain of the disclosed methods are particularly useful for evaluating bisulfite-treated target sequences and determining the degree of target nucleotide methylation. The disclosed methods are well suited for rapidly analyzing a large number of target sequences, typically in one or more multiplex reactions. Kits for performing coupled nuclease and ligase methylation detection assays are also disclosed.

    摘要翻译： 公开了确定通过结合特异性核酸酶催化的反应的至少一种靶核苷酸的甲基化状态的方法，通常与连接反应偶联。 通过检测切割的瓣，连接产物，连接产物替代物，杂交复合物或其组合，可以推断相应的靶核苷酸被甲基化的程度。 某些所公开的方法对于评估亚硫酸氢盐处理的靶序列和确定靶核苷酸甲基化程度特别有用。 所公开的方法非常适合于通常在一个或多个多重反应中快速分析大量目标序列。 还公开了用于进行偶联核酸酶和连接酶甲基化检测测定的试剂盒。

    Methods, reaction mixtures, and kits for ligating polynucleotides
    10.
    发明申请
    Methods, reaction mixtures, and kits for ligating polynucleotides 审中-公开
    方法，反应混合物和用于连接多核苷酸的试剂盒

    公开(公告)号：US20060019288A1

    公开(公告)日：2006-01-26

    申请号：US11173112

    申请日：2005-06-30

    申请人： Mark Andersen ,  H. Wenz ,  Caifu Chen ,  Achim Karger

    发明人： Mark Andersen ,  H. Wenz ,  Caifu Chen ,  Achim Karger

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6855 ,  C12P19/34

    摘要： The present teachings pertain to methods, reaction mixtures, and kits for ligating polynucleotides. In some embodiments, a heat-activatable ligation agent, a phosphorylation agent, and a decontamination agent are included in the same ligation reaction mixture with at least one probe set, at least one linker set, and at least one target polynucleotide. A reaction at a first temperature results in hybridization of the probes to the target, phosphorylation of the probes, and decontamination of unwanted reaction components. A reaction at a second temperature results in the ligation of the probes together. In some embodiments, the present teachings are applied in highly multi-plexed ligation reactions in which a plurality of single nucleotide polymorphisms in a plurality of target polynucleotides are queried, and eventually detected using a mobility dependent analysis technique.

    摘要翻译： 本教导涉及用于连接多核苷酸的方法，反应混合物和试剂盒。 在一些实施方案中，与至少一个探针组，至少一个接头组和至少一个靶多核苷酸在相同的连接反应混合物中包括可热激活的连接剂，磷酸化剂和去污剂。 在第一温度下的反应导致探针与靶的杂交，探针的磷酸化，以及不期望的反应组分的去污。 在第二温度下的反应导致探头连接在一起。 在一些实施方案中，本教导应用于高多重连接的连接反应中，其中查询多个目标多核苷酸中的多个单核苷酸多态性，并且最终使用迁移率依赖性分析技术检测。