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    Nonsymbiotic plant hemoglobins to maintain cell energy status
    1.
    发明授权
    Nonsymbiotic plant hemoglobins to maintain cell energy status 失效
    非共生植物血红蛋白维持细胞能量状态

    公开(公告)号：US06936749B1

    公开(公告)日：2005-08-30

    申请号：US09720206

    申请日：1999-06-24

    申请人： Phillip Guy ,  Stephen Duff ,  Nie Xianzhou ,  Robert Hill ,  Douglas Durnin ,  Aleksander Sowa

    发明人： Phillip Guy ,  Stephen Duff ,  Nie Xianzhou ,  Robert Hill ,  Douglas Durnin ,  Aleksander Sowa

    IPC分类号： A01H5/00 ,  A61K35/12 ,  C07K14/415 ,  C07K14/805 ,  C12N1/20 ,  C12N15/29 ,  C12N15/82

    CPC分类号： C07K14/415 ,  A61K35/12 ,  C07K14/805 ,  C12N1/20 ,  C12N15/8261 ,  Y02A40/146

    摘要： Nonsymbiotic hemoglobins are broadly present across evolution; however, the function of these proteins is unknown. Cultured maize cells have been transformed to constitutively express a barley hemoglobin gene in either the sense (HB+) or antisense (HB−) orientation. Hemoglobin protein in the transformed cell lines was correspondingly higher or lower than in wild type cells under normal atmospheric conditions. Limiting oxygen availability, by placing the cells in a nitrogen atmosphere for 12 hours, had little effect on the energy status of cells constitutively expressing hemoglobin, but had a pronounced effect on both wild type and HB− cells, where ATP levels declined by 27% and 61% respectively. Energy charge was relatively unaffected by the treatment in HB+ and wild type cells, but was reduced from 0.91 to 0.73 in HB− cells suggesting that the latter were incapable of maintaining their energy status under the low oxygen regime. Similar results were observed with P. aeruginosa cells transformed with an Hb expression vector. It is suggested that nonsymbiotic hemoglobins act to maintain the energy status of cells in low oxygen environments and that they accomplish this effect by promoting glycolytic flux through NADH oxidation, resulting in increased substrate level phosphorylation. Nonsymbiotic hemoglobins are likely ancestors of an early form of hemoglobin that sequestered oxygen in low oxygen environments, providing a source of oxygen to oxidize NADH to provide ATP for cell growth and development. This in turn suggests that cells containing increased levels of Hb protein will survive longer under low oxygen tension or high energy demand.

    摘要翻译： 非共生血红蛋白在进化中广泛存在; 然而，这些蛋白质的功能是未知的。 培养的玉米细胞已被转化以组合式表达大鼠血红蛋白基因（HB + />）或反义（HB ）方向。 在正常大气条件下，转化细胞系中的血红蛋白蛋白质相对较高或低于野生型细胞。 通过将细胞置于氮气气氛中12小时来限制氧气供应对组成型表达血红蛋白的细胞的能量状态几乎没有影响，但对野生型和HB 细胞都具有显着的作用， ATP水平分别下降了27％和61％。 能量电荷相对不受HB +和/或野生型细胞治疗的影响，但在HB 细胞中从0.91降低至0.73，表明后者不能维持 低氧状态下的能量状态。 用Hb表达载体转化的铜绿假单胞菌细胞观察到类似的结果。 建议非共生血红蛋白起作用以维持低氧环境中细胞的能量状态，并通过促进糖酵解通过NADH氧化来实现这一作用，从而增加底物水平的磷酸化。 非共生血红蛋白可能是早期形式的血红蛋白的祖先，其在低氧环境中螯合氧，提供氧气来氧化NADH以提供ATP用于细胞生长和发育。 这反过来表明，含有较高水平的Hb蛋白的细胞将在低氧压力或高能量需求下生存更长时间。

    Diverse options order types in an electronic guaranteed entitlement environment
    3.
    发明申请
    Diverse options order types in an electronic guaranteed entitlement environment 有权
    电子保证权利环境中的多种选项订单类型

    公开(公告)号：US20090157539A1

    公开(公告)日：2009-06-18

    申请号：US11881788

    申请日：2007-07-27

    申请人： Paul Adcock ,  Michael Cormack ,  Amy Famstrom ,  Robert Hill

    发明人： Paul Adcock ,  Michael Cormack ,  Amy Famstrom ,  Robert Hill

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/04 ,  G06Q30/06 ,  G06Q40/00 ,  G06Q40/06

    摘要： An enhanced system and method for handling, matching and executing a diverse group of limit-priced orders in an electronic options environment is disclosed. Most of the order types disclosed are automatically repriced and reposted as the NBBO changes to increase their execution opportunities. Market maker entitlements are integrated with the order processing, so that the market maker is guaranteed an allocation of the trade if the market maker is at the NBBO when an order priced at or better than the NBBO is received. Once posted to the order book, the displayed price of an order may be eligible for preferential execution in a market maker entitlement process, regardless of whether the displayed price is original or has been automatically repriced.

    摘要翻译： 公开了一种用于在电子选项环境中处理，匹配和执行不同组限价订单的增强的系统和方法。 公布的大多数订单类型都会随着NBBO的变化而自动重新定位并重新发布，从而增加其执行机会。 市场制造商的权利与订单处理相结合，使得如果收购订单或NBBO以上的订单，则营销商处于NBBO时，营销商可以保证交易分配。 一旦发布到订单，订单的显示价格可能有资格在制作商授权过程中优先执行，无论显示的价格是原始还是自动重新定价。

    Biological control of plant diseases
    5.
    发明申请
    Biological control of plant diseases 审中-公开
    植物病害的生物防治

    公开(公告)号：US20080050344A1

    公开(公告)日：2008-02-28

    申请号：US11898974

    申请日：2007-09-18

    申请人： Philip Elmer ,  Tony Reglinski ,  Robert Hill

    发明人： Philip Elmer ,  Tony Reglinski ,  Robert Hill

    IPC分类号： A01N63/00 ,  A01P3/00

    CPC分类号： A01N63/04

    摘要： The present invention relates to the use of Ulocladium oudemansii as a biological control agent. Processes and compositions for the biological control of Botrytis species using Ulocladium oudemansii are also provided.

    摘要翻译： 本发明涉及乌曲兰紫杉醇作为生物防治剂的用途。 还提供了使用乌克兰斑马鱼的葡萄孢属物种生物控制的方法和组合物。

    Method of Modifying Plant Phenotypes With Nonsymbiotic Hemoglobin
    6.
    发明申请
    Method of Modifying Plant Phenotypes With Nonsymbiotic Hemoglobin 失效
    用非血红蛋白修饰植物表型的方法

    公开(公告)号：US20070256196A1

    公开(公告)日：2007-11-01

    申请号：US10582321

    申请日：2004-12-10

    申请人： Robert Hill ,  Kevin Baron

    发明人： Robert Hill ,  Kevin Baron

    IPC分类号： A01H3/00 ,  A01H1/00 ,  A01H5/00

    CPC分类号： C12N15/8261 ,  C07K14/805 ,  C12N15/825 ,  C12N15/8269 ,  C12N15/827 ,  C12N15/8291 ,  Y02A40/146

    摘要： The present invention provides a method of modifying a plant phenotype by transforming a plant to alter the level of expression of non-symbiotic plant hemoglobin in the plant, whereby the transformed plant exhibits, under normal oxygen conditions, a plant phenotype that is modified as compared to a non-transformed plant. Plants exhibiting modified phenotypes under normal oxygen conditions also are provided. Methods of modifying the response to a plant hormone in a plant also are provided.

    摘要翻译： 本发明提供了通过转化植物以改变植物中非共生植物血红蛋白的表达水平来改变植物表型的方法，由此转化的植物在正常氧条件下表现出相比被修饰的植物表型 到未转化的植物。 还提供了在正常氧条件下表现出修饰表型的植物。 还提供了修改植物中对植物激素的反应的方法。

    Seal structures for wet/dry automatic injectors
    7.
    发明申请
    Seal structures for wet/dry automatic injectors 有权
    湿/干自动注射器的密封结构

    公开(公告)号：US20070142769A1

    公开(公告)日：2007-06-21

    申请号：US11698965

    申请日：2007-01-26

    申请人： Steven Griffiths ,  Robert Hill

    发明人： Steven Griffiths ,  Robert Hill

    IPC分类号： A61M37/00

    CPC分类号： A61M5/31596 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/2066 ,  A61M5/284 ,  A61M5/286 ,  A61M5/3145 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/343 ,  A61M5/348 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/287 ,  A61M2005/3106 ,  A61M2005/3131 ,  A61M2005/3132 ,  A61M2202/064 ,  A61M2205/7536 ,  A61M2205/7545

    摘要： An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.

    摘要翻译： 一种自动药物注射器，其具有用于干药物组分的隔室和用于湿药物组分的隔室。 两个隔室由密封结构分开，当设备被激活时，该密封结构从密封条件转变为混合状态。 密封结构包括擦拭干燥部件隔室中的内壁以防止干燥部件在密封/玻璃界面处积聚的刮水器。 锥形插入件将混合的药物组分漏出到附接的针组件，但是当装置被填充时可以将其移除。 在药剂隔室和针组件之间设置过滤器。 过滤器和针之间的腔室可以更好地流过过滤器。 致动组件驱动密封结构进入混合状态，并迫使混合药物穿过针头进入使用者。

    Flow-path inserts for wet/dry automatic injectors
    8.
    发明申请
    Flow-path inserts for wet/dry automatic injectors 有权
    湿/干自动注射器的流路插入件

    公开(公告)号：US20070142768A1

    公开(公告)日：2007-06-21

    申请号：US11698964

    申请日：2007-01-26

    申请人： Steven Griffiths ,  Robert Hill

    发明人： Steven Griffiths ,  Robert Hill

    IPC分类号： A61M37/00

    CPC分类号： A61M5/31596 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/2066 ,  A61M5/284 ,  A61M5/286 ,  A61M5/3145 ,  A61M5/31513 ,  A61M5/3202 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/343 ,  A61M5/348 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/287 ,  A61M2005/3106 ,  A61M2005/3131 ,  A61M2005/3132 ,  A61M2202/064 ,  A61M2205/7536 ,  A61M2205/7545

    摘要： An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition into a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.

    摘要翻译： 一种自动药物注射器，其具有用于干药物组分的隔室和用于湿药物组分的隔室。 两个隔间由密封结构隔开，密封结构在装置被激活时从密封条件转换成混合状态。 密封结构包括擦拭干燥部件隔室中的内壁以防止干燥部件在密封/玻璃界面处积聚的刮水器。 锥形插入件将混合的药物组分漏出到附接的针组件，但是当装置被填充时可以将其移除。 在药剂隔室和针组件之间设置过滤器。 过滤器和针之间的腔室可以更好地流过过滤器。 致动组件驱动密封结构进入混合状态，并迫使混合药物穿过针头进入使用者。

    Reprice-to-block order
    9.
    发明申请
    Reprice-to-block order 有权
    重传到块顺序

    公开(公告)号：US20060253381A1

    公开(公告)日：2006-11-09

    申请号：US11416942

    申请日：2006-05-03

    申请人： Paul Adcock ,  Michael Cormack ,  Thomas Haller ,  Robert Hill

    发明人： Paul Adcock ,  Michael Cormack ,  Thomas Haller ,  Robert Hill

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/04 ,  G06Q30/0601 ,  G06Q40/00

    摘要： A reprice-to-block order and related market center and process are disclosed which automatically reprice a posted limit order to the price of a block trade executed at an inferior price on a market away from the market center that posted the limit order.

    摘要翻译： 公布了一个重新定价订单和相关的市场中心和流程，自动将贴现的限价订单重新交付给市场上较低价格的块交易的价格，该价格在离市场中心发布限价单的市场上较低。