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39 条记录 (耗时 0.036 秒)

    PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT
    5.
    发明申请
    PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT 审中-公开
    吡哆醛（3,2-D）嘧啶和药物治疗有用的药物组合物

    公开(公告)号：US20080004285A1

    公开(公告)日：2008-01-03

    申请号：US11771924

    申请日：2007-06-29

    申请人： Steven De Jonghe ,  Eduard Dolusic ,  Ling-Jie Gao ,  Piet Andre Herdewijn ,  Wolfgang Pfleiderer

    发明人： Steven De Jonghe ,  Eduard Dolusic ,  Ling-Jie Gao ,  Piet Andre Herdewijn ,  Wolfgang Pfleiderer

    IPC分类号： A61K31/519 ,  C07D487/02

    CPC分类号： C07D471/04

    摘要： This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-α related disorders, viral diseases (including hepatitis C), erectile dysfunction and cell proliferative disorders.

    摘要翻译： 本发明涉及取代吡啶并（3,2-d）嘧啶衍生物，它们的药学上可接受的盐，N-氧化物，溶剂合物，前药和对映异构体，其特别是具有高度活性的免疫抑制剂，以及作为 这在治疗移植排斥和/或某些炎性疾病的治疗中是有用的。 这些衍生物也可用于预防或治疗心血管疾病，中枢神经系统疾病，TNF-α相关病症，病毒性疾病（包括丙型肝炎），勃起功能障碍和细胞增殖性疾病。

    Immunosuppressive effects of pteridine derivatives
    6.
    发明申请
    Immunosuppressive effects of pteridine derivatives 审中-公开
    蝶啶衍生物的免疫抑制作用

    公开(公告)号：US20060189620A1

    公开(公告)日：2006-08-24

    申请号：US11275601

    申请日：2006-01-18

    申请人： Mark Jozef Waer ,  Piet Andre Herdewijn ,  Wolfgang Pfleiderer

    发明人： Mark Jozef Waer ,  Piet Andre Herdewijn ,  Wolfgang Pfleiderer

    IPC分类号： A61K31/525 ,  C07D475/12

    CPC分类号： C07D475/10 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A61K38/13 ,  C07D471/04 ,  C07D475/04 ,  C07D475/08 ,  A61K2300/00

    摘要： This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.

    摘要翻译： 本发明涉及一组三取代和四取代的蝶啶衍生物，其药学上可接受的盐，N-氧化物，溶剂化物，二氢和四氢衍生物和对映异构体，具有特别期望的药物性质，特别是高活性免疫抑制剂，因此是 可用于移植排斥和/或治疗某些炎性疾病的治疗。 这些化合物也可用于预防或治疗心血管疾病，过敏性疾病，中枢神经系统疾病和细胞增殖性疾病。

    Pteridine nucleotide analogs
    7.
    发明授权
    Pteridine nucleotide analogs 失效
    蝶啶核苷酸类似物

    公开(公告)号：US06716971B1

    公开(公告)日：2004-04-06

    申请号：US09786666

    申请日：2001-06-15

    申请人： Mary E. Hawkins ,  Wolfgang Pfleiderer ,  Frank Balis

    发明人： Mary E. Hawkins ,  Wolfgang Pfleiderer ,  Frank Balis

    IPC分类号： C07H2100

    CPC分类号： C07H21/00 ,  C12Q1/6816 ,  C12Q2565/107 ,  C12Q2563/107 ,  C12Q2525/301 ,  C12Q2531/113 ,  C12Q2561/119

    摘要： The invention provides pteridine nucleotides of formula (I) which are highly fluorescent and which can be used in the chemical synthesis of fluorescent oligonucleotide. The invention further provides for fluorescent oligonucleotide comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures. The pteridine nucleotides are more stable and possess higher quantum yields than structurally similar pteridine nucleotides.

    摘要翻译： 本发明提供了高度荧光的式（I）的蝶啶核苷酸，可用于荧光寡核苷酸的化学合成。 本发明还提供了包含一个或多个蝶啶核苷酸的荧光寡核苷酸。 此外，本发明提供了可用作DNA扩增方法中构成单体的蝶啶核苷三磷酸。 蝶啶核苷酸比结构上类似的蝶啶核苷酸更稳定，具有更高的量子产率。

    Base-modified derivatives of 2′,5′-oligoadenylate and antiviral uses thereof
    8.
    发明授权
    Base-modified derivatives of 2′,5′-oligoadenylate and antiviral uses thereof 有权
    2'，5'-寡聚腺苷酸的碱基修饰的衍生物及其抗病毒用途

    公开(公告)号：US06281201B1

    公开(公告)日：2001-08-28

    申请号：US09445552

    申请日：1999-12-08

    申请人： Robert J. Suhadolnik ,  Wolfgang Pfleiderer

    发明人： Robert J. Suhadolnik ,  Wolfgang Pfleiderer

    IPC分类号： A61K3170

    CPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04

    摘要： Antiviral compounds have the formula wherein m is zero, 1, 2 or 3; n is from 1 to 8, preferably 1, 2 or 3; most preferably 1 or 2; R is independently selected from the group consisting of  provided that all R may not be R1 is independently selected from the group consisting of hydroxyl and hydrogen; R2 is independently selected from the group consisting of oxygen and sulfur; or water soluble salts thereof.

    摘要翻译： 抗病毒化合物的制备方法为零，1,2或3; n为1至8，优选1,2或3; 最优选1或2; R独立地选自由以下组成的组：所有R不为R 1独立地选自羟基和氢; R 2独立地选自氧和硫;或水溶性 的盐。