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    METHOD FOR DETERMINING SURIVIVAL PROGNOSIS OF PATIENTS SUFFERING FROM NON-SMALL CELL LUNG CANCER (NSCLC)
    5.
    发明申请
    METHOD FOR DETERMINING SURIVIVAL PROGNOSIS OF PATIENTS SUFFERING FROM NON-SMALL CELL LUNG CANCER (NSCLC) 有权
    确定非小细胞肺癌（NSCLC）患者生存预后的方法

    公开(公告)号：US20130017963A1

    公开(公告)日：2013-01-17

    申请号：US13138849

    申请日：2010-04-12

    申请人： Richard De Wijn ,  Robby Ruijtenbeek ,  Maria Helena Hilhorst

    发明人： Richard De Wijn ,  Robby Ruijtenbeek ,  Maria Helena Hilhorst

    IPC分类号： C40B30/04

    CPC分类号： G01N33/57423 ,  C12Q1/485

    摘要： The present invention relates to a method for determining the survival prognosis of patients suffering from non-small cell lung cancer. More specifically, the present invention provides methods which measure kinase activity by studying phosphorylation levels in response to a kinase inhibitor and profiles in samples obtained from patients diagnosed with non-small cell lung cancer. The present invention also provides methods for predicting the response of a patient diagnosed with non-small cell lung cancer to a medicament.

    摘要翻译： 本发明涉及一种确定患有非小细胞肺癌患者的生存预后的方法。 更具体地，本发明提供了通过研究响应于激酶抑制剂的磷酸化水平和从诊断为非小细胞肺癌的患者获得的样品中的分布来测量激酶活性的方法。 本发明还提供了用于预测诊断为非小细胞肺癌的患者对药物的反应的方法。

    Masked Solid Porous Supports Allowing Fast And Easy Reagent Exchange To Accelerate Electrode-Based Microarrays
    8.
    发明申请
    Masked Solid Porous Supports Allowing Fast And Easy Reagent Exchange To Accelerate Electrode-Based Microarrays 审中-公开
    掩蔽固体多孔支持允许快速和容易的试剂交换加速基于电极的微阵列

    公开(公告)号：US20080090739A1

    公开(公告)日：2008-04-17

    申请号：US11662397

    申请日：2005-09-28

    申请人： Marinus Van Beuningen ,  Hendrik Van Damme ,  Richard De Wijn ,  Jurry Hannink ,  Colin Ingham

    发明人： Marinus Van Beuningen ,  Hendrik Van Damme ,  Richard De Wijn ,  Jurry Hannink ,  Colin Ingham

    IPC分类号： C40B60/12 ,  C23C14/34 ,  C25D7/00

    CPC分类号： G01N33/5438 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2300/12 ,  B01L2400/0415 ,  B01L2400/086 ,  G01N2035/00158

    摘要： Solid porous supports find use in array analysis, as they offer high surface area for contacting the analyzed sample. The present invention provides a solid porous support suitable for array analysis having first and second surfaces, and comprising channels extending from said first surface to said second surface, characterised in that at least one conductive material is applied to predefined regions on said first surface and/or on said second surface and/or inside the channels contained within said solid porous support. Such conductive material(s) may form a high-precision grid delineating physically distinct compartments within the support and thus reduce the risk of cross-contamination in array analysis. Additionally, such conductive material(s) may directly participate in reactions performed on the array by means of their electrical and/or thermal conductivity.

    摘要翻译： 固体多孔载体用于阵列分析，因为它们提供高表面积以接触分析的样品。 本发明提供了一种适于阵列分析的固体多孔载体，其具有第一和第二表面，并且包括从所述第一表面延伸到所述第二表面的通道，其特征在于，至少一种导电材料被施加到所述第一表面上的预定区域和/ 或在所述第二表面和/或包含在所述固体多孔载体内的通道的内部。 这种导电材料可以形成描述支撑体内物理上不同的隔室的高精度网格，从而降低阵列分析中交叉污染的风险。 另外，这种导电材料可以通过它们的电和/或导热性直接参与在阵列上进行的反应。