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8 条记录 (耗时 0.04 秒)

    Systems and methods of forming particles
    1.
    发明申请
    Systems and methods of forming particles 审中-公开
    形成颗粒的系统和方法

    公开(公告)号：US20070054119A1

    公开(公告)日：2007-03-08

    申请号：US11368263

    申请日：2006-03-03

    申请人： Piotr Garstecki ,  Douglas Weibel ,  Irina Gitlin ,  Shoji Takeuchi ,  Shengqing Xu ,  Zhihong Nie ,  Min Seo ,  Patrick Lewis ,  Eugenia Kumacheva ,  Howard Stone ,  George Whitesides

    发明人： Piotr Garstecki ,  Douglas Weibel ,  Irina Gitlin ,  Shoji Takeuchi ,  Shengqing Xu ,  Zhihong Nie ,  Min Seo ,  Patrick Lewis ,  Eugenia Kumacheva ,  Howard Stone ,  George Whitesides

    IPC分类号： B32B1/00

    CPC分类号： B01J19/0093 ,  B01F3/0807 ,  B01F13/0062 ,  B01J19/06 ,  B01J2219/00873 ,  B22F1/0007 ,  B22F9/06 ,  Y10T428/2982

    摘要： The present invention generally relates to systems and methods of forming particles and, in certain aspects, to systems and methods of forming particles that are substantially monodisperse. Microfluidic systems and techniques for forming such particles are provided, for instance, particles may be formed using gellation, solidification, and/or chemical reactions such as cross-linking, polymerization, and/or interfacial polymerization reactions. In one aspect, the present invention is directed to a plurality of particles having an average dimension of less than about 500 micrometers and a distribution of dimensions such that no more than about 5% of the particles have a dimension greater than about 10% of the average dimension, which can be made via microfluidic systems. In one set of embodiments, at least some of the particles may comprise a metal, and in certain embodiments, at least some of the particles may comprise a magnetizable material. In another set of embodiments, at least some of the particles may be porous. In some embodiments, the invention includes non-spherical particles. Non-spherical particles may be formed, for example, by urging a fluidic droplet into a channel having a smallest dimension that is smaller than the diameter of a perfect mathematical sphere having a volume of the droplet, and solidifying the droplet, and/or by exposing at least a portion of a plurality of particles to an agent able to remove at least a portion of the particles.

    摘要翻译： 本发明一般涉及形成颗粒的系统和方法，并且在某些方面涉及形成基本上单分散的颗粒的体系和方法。 提供了用于形成这种颗粒的微流体系统和技术，例如，可以使用凝胶化，固化和/或化学反应如交联，聚合和/或界面聚合反应形成颗粒。 在一个方面，本发明涉及平均尺寸小于约500微米的多个颗粒和尺寸分布，使得不超过约5％的颗粒具有大于所述颗粒的约10％的尺寸 平均尺寸，可以通过微流体系统进行。 在一组实施方案中，至少一些颗粒可以包含金属，并且在某些实施方案中，至少一些颗粒可以包含可磁化材料。 在另一组实施方案中，至少一些颗粒可以是多孔的。 在一些实施方案中，本发明包括非球形颗粒。 非球形颗粒可以例如通过将流体液滴推入具有小于具有液滴体积的完美数学球体的直径的最小尺寸的通道，和/或通过 将多个颗粒的至少一部分暴露于能除去至少一部分颗粒的试剂。

    Formulations limiting spread of pulmonary infections
    3.
    发明申请
    Formulations limiting spread of pulmonary infections 审中-公开
    限制肺部感染传播的制剂

    公开(公告)号：US20050220720A1

    公开(公告)日：2005-10-06

    申请号：US10513165

    申请日：2003-05-01

    申请人： David Edwards ,  Howard Stone

    发明人： David Edwards ,  Howard Stone

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61L9/04 ,  A61M11/00

    CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/008

    摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

    摘要翻译： 已经开发了用于肺部输送以治疗或减少诸如病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。

    PHOTOELECTRIC CELLS INCORPORATING WRINKLES AND FOLDS TO ENHANCE EFFICIENCY AND BENDABILITY AND METHOD OF MAKING
    5.
    发明申请
    PHOTOELECTRIC CELLS INCORPORATING WRINKLES AND FOLDS TO ENHANCE EFFICIENCY AND BENDABILITY AND METHOD OF MAKING 审中-公开
    光电池加入皱纹和加强效率和弯曲性及其制作方法

    公开(公告)号：US20140261675A1

    公开(公告)日：2014-09-18

    申请号：US14214564

    申请日：2014-03-14

    申请人： Yueh-Lin Loo ,  Jongbok Kim ,  Pilnam Kim ,  Howard Stone ,  Nicolas Pegard ,  Jason Fleischer

    发明人： Yueh-Lin Loo ,  Jongbok Kim ,  Pilnam Kim ,  Howard Stone ,  Nicolas Pegard ,  Jason Fleischer

    IPC分类号： H01L31/0236 ,  H01L51/44

    CPC分类号： H01L51/447 ,  H01L51/0037 ,  H01L51/0097 ,  H01L51/4253 ,  Y02E10/549

    摘要： A photovoltaic cell and method of making are disclosed. The photovoltaic cell includes a substrate having a surface at least partially covered in wrinkles and folds, the folds dividing the surface into a plurality of domains. A photoactive layer is formed on the substrate. At least one transparent electrode is coupled to the photoactive layer and configured to allow transmission of light into the photoactive layer. The domains may have a wrinkle periodicity of less than 2 μm. The folds may have a fold density of less than 0.25. The transport layer may comprise PEDOT:PSS. The photoactive layer may comprise P3HT:PCBM. The photoactive layer may comprise a bulk heterojunction.

    摘要翻译： 公开了一种光伏电池及其制造方法。 光伏电池包括具有至少部分地被折皱和折叠的表面的基底，该折叠将表面分成多个畴。 在基板上形成光敏层。 至少一个透明电极耦合到光敏层并且被配置为允许光透射到光活性层中。 这些区域的皱纹周期可能小于2μm。 折叠可以具有小于0.25的折叠密度。 传输层可以包括PEDOT：PSS。 光敏层可以包括P3HT：PCBM。 光活性层可以包括体异质结。

    Surgical system for joints
    7.
    发明申请
    Surgical system for joints 审中-公开
    关节手术系统

    公开(公告)号：US20070010818A1

    公开(公告)日：2007-01-11

    申请号：US11175653

    申请日：2005-07-06

    申请人： Howard Stone ,  Larry Backes

    发明人： Howard Stone ,  Larry Backes

    IPC分类号： A61B17/58

    CPC分类号： A61B17/683 ,  A61B17/1775 ,  A61B17/562 ,  A61B2017/565

    摘要： A surgical kit including a surgical guide system for drilling bones at a joint, a surgical implant for attachment to the bones at the joint, and a surgical implant for attachment to the bones at the joint.

    摘要翻译： 一种手术套件，包括用于在关节处钻骨的外科手术引导系统，用于附接到关节处的骨骼的外科植入物，以及用于附接到关节处的骨骼的外科植入物。

    Valving for multi-stage vacuum pumps
    8.
    发明申请
    Valving for multi-stage vacuum pumps 失效
    多级真空泵阀门

    公开(公告)号：US20050058552A1

    公开(公告)日：2005-03-17

    申请号：US10920674

    申请日：2004-08-18

    申请人： Nigel Schofield ,  Howard Stone

    发明人： Nigel Schofield ,  Howard Stone

    IPC分类号： F04B25/02 ,  F04B37/14 ,  F04B39/08 ,  B01D8/00 ,  F04B3/00

    CPC分类号： F04B37/14 ,  F04B25/02 ,  F04B39/08

    摘要： A multi-stage vacuum pump comprises a first piston in a first cylinder defining a first stage pumping chamber and a second piston in a second cylinder defining a second stage pumping chamber. The pump has a spool valve between the first and second cylinders for controlling flow from the first stage pumping chamber to the second stage pumping chamber. Either the first cylinder and the first piston or the second cylinder and the second piston being stepped so as to define a third stage pumping chamber. The spool valve is arranged to control the flow from the second stage pumping chamber to the third stage pumping chamber.

    摘要翻译： 多级真空泵包括限定第一级泵送室的第一气缸中的第一活塞和限定第二级泵送室的第二气缸中的第二活塞。 该泵具有在第一和第二气缸之间的滑阀，用于控制从第一级泵送室到第二级泵送室的流动。 第一气缸和第一活塞或第二气缸和第二活塞都是阶梯式的，以便限定第三级泵送室。 滑阀被布置成控制从第二级泵送室到第三级泵送室的流量。