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1.发明申请公开(公告)号：US20090226989A1
公开(公告)日：2009-09-10
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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2.发明申请Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same 审中-公开东方药物和密切相关物种的转基因酵母和使用相同的发酵过程公开(公告)号：US20120129230A1
公开(公告)日：2012-05-24
申请号：US13316044
申请日：2011-12-09
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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3.发明授权公开(公告)号：US08097448B2
公开(公告)日：2012-01-17
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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4.发明授权公开(公告)号：US08440451B2
公开(公告)日：2013-05-14
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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5.发明授权公开(公告)号：US07943366B2
公开(公告)日：2011-05-17
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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6.发明申请Methods and materials for the production of organic products in cells of Candida species 审中-公开在假丝酵母菌种细胞中生产有机产物的方法和材料公开(公告)号：US20070092956A1
公开(公告)日：2007-04-26
申请号：US11507289
申请日：2006-08-21
申请人： Vineet Rajgarhia , Merja Penttila , Laura Ruohonen , Marja Ilmen , Kari Koivuranta , Pirkko Suominen
发明人： Vineet Rajgarhia , Merja Penttila , Laura Ruohonen , Marja Ilmen , Kari Koivuranta , Pirkko Suominen
CPC分类号： C12N15/81 , C12N9/0006 , C12N15/815 , C12P7/56
摘要： The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Candida cells, methods for making the Candida cells, and their use in production of organic products, particularly lactic acid.
摘要翻译： 本发明涉及作为Crabtree阴性表型的细胞的生物催化剂，其包含编码与细胞异源的基因的表达载体，其能够增加有机产物的产生。 更具体地，本发明涉及遗传修饰的念珠菌细胞，制备念珠菌细胞的方法，以及它们在生产有机产物，特别是乳酸中的用途。
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7.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287506A1
公开(公告)日：2011-11-24
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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8.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287505A1
公开(公告)日：2011-11-24
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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9.发明授权公开(公告)号：US08623633B2
公开(公告)日：2014-01-07
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12N1/00
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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10.发明申请公开(公告)号：US20060234364A1
公开(公告)日：2006-10-19
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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