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1.发明申请公开(公告)号：US20090226989A1
公开(公告)日：2009-09-10
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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2.发明申请Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same 审中-公开东方药物和密切相关物种的转基因酵母和使用相同的发酵过程公开(公告)号：US20120129230A1
公开(公告)日：2012-05-24
申请号：US13316044
申请日：2011-12-09
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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3.发明授权公开(公告)号：US08097448B2
公开(公告)日：2012-01-17
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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4.发明申请YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL 审中-公开具有从二羟基乙酸酯磷酸盐到甘油的破坏途径的YEAST细胞公开(公告)号：US20090053782A1
公开(公告)日：2009-02-26
申请号：US12281286
申请日：2007-03-13
申请人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
发明人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
CPC分类号： B65G15/12 , B65G17/12 , C12N15/52 , C12P7/06 , C12P7/40 , C12P7/56 , E01B29/32 , Y02E50/17 , Y10T137/85986
摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
摘要翻译： 酵母细胞被遗传修饰以破坏从二羟基丙酮到甘油的天然代谢途径。 在某些方面，酵母细胞是克鲁维酵母属，假丝酵母属或发chen类。 在其它方面，酵母细胞能够产生至少一种有机酸，如乳酸盐。 酵母细胞比野生型菌株产生明显较少的甘油，并且通常产生更高产量的所需发酵产物。 本发明的酵母细胞在培养时经常生长良好，尽管它们的甘油产量减少。
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5.发明申请DECARBOXYLASE PROTEINS WITH HIGH KETO-ISOVALERATE DECARBOXYLASE ACTIVITY 审中-公开具有高KETO-ISOVALERATE脱羧酶活性的脱羧蛋白公开(公告)号：US20150259710A1
公开(公告)日：2015-09-17
申请号：US13561560
申请日：2012-07-30
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/88 , C12Y101/01001 , C12Y101/01086 , C12Y401/01 , Y02E50/10
摘要： The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise at least one nucleic acid molecule encoding a polypeptide with keto-isovalerate decarboxylase (KIVD) activity, wherein said polypeptide is at least about 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a polypeptide selected from SEQ ID NOs: 1-214. Also provided are modified decarboxylases exhibiting an improved ability to utilize α-ketoisovalerate as a substrate in various beneficial enzymatic conversions.
摘要翻译： 本发明涉及包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。 在本发明的各个方面，重组微生物可包含编码具有酮 - 异戊酸脱羧酶（KIVD）活性的多肽的至少一种核酸分子，其中所述多肽至少约65％，70％，75％，80％ 与选自SEQ ID NO：1-214的多肽的85％，90％，91％，92％，93％，94％，95％，96％，97％，98％或99％相同。 还提供了改进的脱羧酶，其表现出在各种有益的酶转化中利用α-酮异戊酸作为底物的改进能力。
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