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1.发明申请公开(公告)号：US20090226989A1
公开(公告)日：2009-09-10
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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2.发明申请Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same 审中-公开东方药物和密切相关物种的转基因酵母和使用相同的发酵过程公开(公告)号：US20120129230A1
公开(公告)日：2012-05-24
申请号：US13316044
申请日：2011-12-09
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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3.发明授权公开(公告)号：US08097448B2
公开(公告)日：2012-01-17
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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4.发明授权公开(公告)号：US08440451B2
公开(公告)日：2013-05-14
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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5.发明授权公开(公告)号：US07943366B2
公开(公告)日：2011-05-17
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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6.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287506A1
公开(公告)日：2011-11-24
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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7.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287505A1
公开(公告)日：2011-11-24
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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8.发明授权公开(公告)号：US08623633B2
公开(公告)日：2014-01-07
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12N1/00
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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9.发明申请公开(公告)号：US20060234364A1
公开(公告)日：2006-10-19
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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10.发明申请YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL 审中-公开具有从二羟基乙酸酯磷酸盐到甘油的破坏途径的YEAST细胞公开(公告)号：US20090053782A1
公开(公告)日：2009-02-26
申请号：US12281286
申请日：2007-03-13
申请人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
发明人： Catherine Asleson Dundon , Pirkko Suominen , Aristos Aristidou , Brian J. Rush , Kari Koivuranta , Benjamin Matthew Hause , Thomas William McMullin , Kevin Roberg-Perez
CPC分类号： B65G15/12 , B65G17/12 , C12N15/52 , C12P7/06 , C12P7/40 , C12P7/56 , E01B29/32 , Y02E50/17 , Y10T137/85986
摘要： Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
摘要翻译： 酵母细胞被遗传修饰以破坏从二羟基丙酮到甘油的天然代谢途径。 在某些方面，酵母细胞是克鲁维酵母属，假丝酵母属或发chen类。 在其它方面，酵母细胞能够产生至少一种有机酸，如乳酸盐。 酵母细胞比野生型菌株产生明显较少的甘油，并且通常产生更高产量的所需发酵产物。 本发明的酵母细胞在培养时经常生长良好，尽管它们的甘油产量减少。
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