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公开(公告)号：US20100114059A1
公开(公告)日：2010-05-06
申请号：US12262798
申请日：2008-10-31
IPC分类号： A61M5/20
CPC分类号： A61M5/1408 , A61M5/1413 , A61M5/1452 , A61M5/14566 , A61M5/165 , A61M5/2425 , A61M5/2466 , A61M37/0069
摘要： A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.
摘要翻译： 用于将治疗剂递送到患者的递送系统包括导管，停止特征，容器和棒。 导管具有近端和远端，并且包括限定延伸到导管的远端的内腔的主体。 停止特征靠近导管的远端。 容器构造成容纳治疗剂，并且可插入并可滑动地一次性地在导管的内腔中。 容器还构造成接合导管的停止特征。 该杆在导管的内腔中可滑动地一次性使用。 当容器与停止特征接合时，杆的远端在管腔中滑动迫使治疗剂离开容器并离开管腔。 停止功能被配置为禁止容器离开管腔。
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2.发明授权公开(公告)号：US07628780B2
公开(公告)日：2009-12-08
申请号：US11000798
申请日：2004-11-30
申请人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
发明人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00243 , A61B2017/00247 , A61B2017/2926 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M25/0084
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长轴和远端注射头，用于将针驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以转换成针驱动力。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。
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3.发明申请INJECTION NEEDLE HAVING LATERAL DELIVERY PORTS AND METHOD FOR THE MANUFACTURE THEREOF 审中-公开具有横向输送口的注射针及其制造方法公开(公告)号：US20080172012A1
公开(公告)日：2008-07-17
申请号：US11555086
申请日：2006-10-31
申请人： Prasanga D. Hiniduma-Lokuge , Daniel C. Sigg , John L. Sommer , Matthew D. Bonner , Brian C.A. Fernandes
发明人： Prasanga D. Hiniduma-Lokuge , Daniel C. Sigg , John L. Sommer , Matthew D. Bonner , Brian C.A. Fernandes
IPC分类号： A61M5/32
CPC分类号： A61M5/3291 , A61M5/3286 , A61M25/00 , B21G1/08
摘要： An injection needle comprises an elongated body having an outer surface and an inner surface defining a longitudinal channel through the tubular body. The elongated body further comprises a distal end and at least one lateral delivery port extending from the inner surface to the outer surface proximate the distal end and fluidly coupled to the longitudinal channel. A distal tip is coupled to the distal end and comprises a radio-opaque material.
摘要翻译： 注射针包括具有外表面和限定通过管状体的纵向通道的内表面的细长体。 细长主体还包括远端和至少一个侧向输送端口，该至少一个侧向输送端口从内表面延伸到靠近远端的外表面并且流体地连接到纵向通道。 远侧末端联接到远端并且包括不透射线材料。
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公开(公告)号：US20100274221A1
公开(公告)日：2010-10-28
申请号：US12767224
申请日：2010-04-26
CPC分类号： A61B5/036 , A61B5/0031 , A61B5/0215 , A61B5/4839 , A61M5/14276 , A61M5/16854 , A61M5/1723 , A61M2005/1726 , A61M2205/3331 , A61M2205/3334
摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
摘要翻译： 用于调节对患有或具有肺动脉高压的风险的患者的治疗流体的递送的方法包括以预定的速率经由导管将治疗流体引入患者体内。 定位导管以将流体输送到右心室或肺动脉。 导管是单向阀，其构造成允许流体从导管流到目标位置。 该方法还包括通过监测内部导管压力来监测目标位置的压力，并且基于所监测的压力来调节治疗流体被引入导管的速率。 如果内部导管压力增加，流体被引入导管的速率增加，并且如果内部导管压力降低，则将流体引入导管的速率降低。
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5.发明申请Devices and Methods for Interstitial Injection of Biologic Agents into Tissue 审中-公开将组织间质注射生物制剂的装置和方法公开(公告)号：US20100069844A1
公开(公告)日：2010-03-18
申请号：US12609225
申请日：2009-10-30
申请人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
发明人： Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott Eric Jahns , Victor T. Chen
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00243 , A61B2017/00247 , A61B2017/2926 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M25/0084
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译： 将生物制剂注入组织的装置和方法。 设备具有细长轴和远端注射头，用于将针驱动到组织中，并通过针将药剂注射到组织中。 沿着轴引导的纵向力可以转换成针驱动力。 一些装置提供可控的可变针穿透深度。 设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。 其他装置包括用于驱动和缩回针的可充气构件。 还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。 本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。
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公开(公告)号：US08672917B2
公开(公告)日：2014-03-18
申请号：US12767224
申请日：2010-04-26
IPC分类号： A61M31/00
CPC分类号： A61B5/036 , A61B5/0031 , A61B5/0215 , A61B5/4839 , A61M5/14276 , A61M5/16854 , A61M5/1723 , A61M2005/1726 , A61M2205/3331 , A61M2205/3334
摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
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公开(公告)号：US20120234877A1
公开(公告)日：2012-09-20
申请号：US13231936
申请日：2011-09-13
IPC分类号： A47D13/02
CPC分类号： A47D13/025
摘要： An apparatus to carry an infant against a chest of a person that includes a central panel, a first side panel, a second side panel, a first infant seat and a fastening mechanism. The first side panel is attached to the central panel and has a first aperture formed therein. The second side panel is attached to the central panel and has a second aperture formed therein. The first infant seat is attached to the central panel. The first infant seat is adapted to receive a portion of the infant. The fastening mechanism is operably attached to at least one of the first side panel and the second side panel for securing the first side panel and the second side panel around a torso of the person.
摘要翻译： 携带婴儿靠在包括中央面板，第一侧面板，第二侧面板，第一婴儿座椅和紧固机构的人的胸部的装置。 第一侧板附接到中心板并且具有形成在其中的第一孔。 第二侧板附接到中心板并且具有形成在其中的第二孔。 第一个婴儿座椅连接到中央面板。 第一婴儿座椅适于接收婴儿的一部分。 紧固机构可操作地附接到第一侧板和第二侧板中的至少一个，用于将第一侧板和第二侧板围绕人的躯干固定。
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公开(公告)号：US20110123593A1
公开(公告)日：2011-05-26
申请号：US13008501
申请日：2011-01-18
CPC分类号： A61F2/02 , A61F2/2493 , A61F2250/0067
摘要： A self-fixating scaffold delivers therapeutic material to tissue for treating various diseases/conditions. A scaffold holds the therapeutic material and is implanted into the tissue. A fixation element anchors the scaffold in the tissue making the scaffold less likely to become dislodged.
摘要翻译： 自固定支架将治疗材料递送到组织以治疗各种疾病/病症。 支架固定治疗材料并植入组织。 固定元件将支架锚定在组织中，使得支架不太可能脱落。
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9.发明授权公开(公告)号：US07740623B2
公开(公告)日：2010-06-22
申请号：US11159752
申请日：2005-06-23
申请人： Asha S. Nayak , Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott E. Jahns , Victor T. Chen
发明人： Asha S. Nayak , Matthew D. Bonner , Paul T. Rothstein , Prasanga D. Hiniduma-Lokuge , James R. Keogh , Raymond W. Usher , Scott E. Jahns , Victor T. Chen
CPC分类号： A61B17/205 , A61B17/00491 , A61B17/0206 , A61B17/3478 , A61B2017/00247 , A61B2017/0243 , A61B2017/2936 , A61B2017/2939 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61M5/32 , A61M25/0084
摘要： The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
摘要翻译： 本发明公开了一种通过将物质注入心肌来治疗心肌缺血/缺血损伤的方法。 注射的物质通过提供结合生物治疗的机械加强或机械增强物有助于防止负性适应性重塑。 公开了许多注射用物质，包括多成分物质如血小板凝胶和其他物质。 所公开的物质可以含有增加/增强注射效果的添加剂。 本发明还公开了用于注入物质的装置。 该装置可以包括用于确保针不超过心肌内的所需深度的装置。 该装置还可以包括具有多个内腔的针，使得血小板凝胶的组分将在注射部位组合并开始在心肌中聚合。
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公开(公告)号：US20080149674A1
公开(公告)日：2008-06-26
申请号：US11959135
申请日：2007-12-18
IPC分类号： A47D13/02
CPC分类号： A47D13/025
摘要： An infant carrier includes a plurality of sections to wrap around a wearer's torso, in order to hold an infant against a chest of a wearer. The sections include a front panel, to enclose the chest, and a back section, extending from the front panel, to traverse across a back of the wearer. An inner seat for the infant is attached to an interior surface of the front panel. The front panel may include a layer of insulation and be waterproofed so that the infant carrier may function as an incubator. The carrier may be held around the torso by an attachment element having first and second mating parts, located along a width of the front panel and along the back section, respectively. The sections may also include a sash to wrap across the front panel from beneath a first shoulder to over a second shoulder of the wearer.
摘要翻译： 婴儿背带包括多个部分以围绕穿着者的躯干包裹，以便将婴幼儿靠在佩戴者的胸部上。 这些部分包括前面板，以封闭胸部，以及从前面板延伸的后部横穿穿着者的背部。 用于婴儿的内座椅附接到前面板的内表面。 前面板可以包括绝缘层，并且是防水的，使得婴儿载体可以用作培养箱。 载体可以通过具有第一和第二配合部分的附接元件保持在躯干周围，该第一和第二配合部分分别沿着前面板的宽度并沿着后部分布。 这些部分还可以包括窗框，以从穿戴者的第一肩部下方覆盖到前面板上方穿过穿戴者的第二肩部。
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