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公开(公告)号：US08870848B2
公开(公告)日：2014-10-28
申请号：US12262798
申请日：2008-10-31
CPC分类号： A61M5/1408 , A61M5/1413 , A61M5/1452 , A61M5/14566 , A61M5/165 , A61M5/2425 , A61M5/2466 , A61M37/0069
摘要： A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.
摘要翻译： 用于将治疗剂递送到患者的递送系统包括导管，停止特征，容器和棒。 导管具有近端和远端，并且包括限定延伸到导管的远端的内腔的主体。 停止特征靠近导管的远端。 容器构造成容纳治疗剂，并且可插入并可滑动地一次性地在导管的内腔中。 容器还构造成接合导管的停止特征。 该杆在导管的内腔中可滑动地一次性使用。 当容器与停止特征接合时，杆的远端在管腔中滑动迫使治疗剂离开容器并离开管腔。 停止功能被配置为禁止容器离开管腔。
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公开(公告)号：US20100114059A1
公开(公告)日：2010-05-06
申请号：US12262798
申请日：2008-10-31
IPC分类号： A61M5/20
CPC分类号： A61M5/1408 , A61M5/1413 , A61M5/1452 , A61M5/14566 , A61M5/165 , A61M5/2425 , A61M5/2466 , A61M37/0069
摘要： A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.
摘要翻译： 用于将治疗剂递送到患者的递送系统包括导管，停止特征，容器和棒。 导管具有近端和远端，并且包括限定延伸到导管的远端的内腔的主体。 停止特征靠近导管的远端。 容器构造成容纳治疗剂，并且可插入并可滑动地一次性地在导管的内腔中。 容器还构造成接合导管的停止特征。 该杆在导管的内腔中可滑动地一次性使用。 当容器与停止特征接合时，杆的远端在管腔中滑动迫使治疗剂离开容器并离开管腔。 停止功能被配置为禁止容器离开管腔。
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公开(公告)号：US20070189025A1
公开(公告)日：2007-08-16
申请号：US10569084
申请日：2004-08-27
IPC分类号： B60Q1/124
CPC分类号： G01D11/28
摘要： An electric dashboard actuator including an electric motor driving an indicator. The electric motor includes a hollow output shaft of which the ends are located at and flush with two opposite surfaces of the motor, and the indicator includes a male coupling member with a cross-section matching the cross-section of the hollow motor output shaft. One motor surface includes a male or female coupling perpendicular to the surface.
摘要翻译： 包括驱动指示器的电动马达的电气仪表板执行器。 电动机包括中空输出轴，其端部位于并与电动机的两个相对表面齐平，并且该指示器包括具有与中空电动机输出轴的横截面匹配的横截面的阳联接构件。 一个电动机表面包括垂直于表面的阳或阴耦合。
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4.发明申请公开(公告)号：US20050177097A1
公开(公告)日：2005-08-11
申请号：US10903599
申请日：2004-07-30
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和 右美托咪定）。
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公开(公告)号：US08859273B2
公开(公告)日：2014-10-14
申请号：US11022172
申请日：2004-12-22
申请人： Daniel Sigg , James A. Coles, Jr. , Erica TenBroek
发明人： Daniel Sigg , James A. Coles, Jr. , Erica TenBroek
CPC分类号： C07K14/705 , A61K35/34 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143 , C12N2840/203
摘要： The subject invention is directed to methods of treating cardiac pacing dysfunction by administering HCN genes, alone or in combination with other genes.
摘要翻译： 本发明涉及通过单独或与其它基因组合施用HCN基因来治疗心脏起搏功能障碍的方法。
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公开(公告)号：US08347807B2
公开(公告)日：2013-01-08
申请号：US12301706
申请日：2007-05-23
IPC分类号： G01D11/28
CPC分类号： G01D11/28 , B60K2350/1064 , G01D13/265
摘要： A dashboard indicator module including a rotating actuator including a hollow output shaft controlling movement of an indicator with a light conducting path, connected to a light source, diffusing a light at an angle, and a reduction gear set. The external diameter of the conducting path is between 2.6 and 5.5 millimeters.
摘要翻译： 一种仪表板指示器模块，包括旋转致动器，其包括中空输出轴，其控制指示器与导光路径的移动，连接到光源，以一角度散射光和减速齿轮组。 导电路径的外径为2.6至5.5毫米。
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7.发明申请公开(公告)号：US20060247697A1
公开(公告)日：2006-11-02
申请号：US11116621
申请日：2005-04-28
申请人： Vinod Sharma , Daniel Sigg
发明人： Vinod Sharma , Daniel Sigg
IPC分类号： A61N1/362
CPC分类号： A61N1/362 , A61K9/0019 , A61K31/221 , A61K38/177 , A61N1/0568
摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.
摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用试剂用于调制心脏传导系统中的节点，包括使用一个和一组K + SUPER通道或等同物的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。
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公开(公告)号：US20110293681A1
公开(公告)日：2011-12-01
申请号：US13035535
申请日：2011-02-25
申请人： Judd Berlin , Daniel Sigg
发明人： Judd Berlin , Daniel Sigg
IPC分类号： A61K9/70 , A61K31/7004 , A01P1/00 , A61K33/14 , A61K31/14 , A61P31/16 , A61P31/04 , A61P1/00 , A61P27/02 , A61P11/00 , A61P1/12 , A61P17/00 , A61P13/02 , A61P31/10 , A61P11/08 , A61P31/14 , A61P33/06 , A61P31/22 , A61P7/00 , A61K31/695
CPC分类号： A61L15/58 , A61L15/46 , A61L2300/208 , A61L2300/21 , A61L2300/404
摘要： The present invention provides for topical adhesive patch that includes a backing having a front side and a back side; a formulation in contact with the front side of the backing, the formulation including an adhesive; and at least one antimicrobial. The antimicrobial is integrally bonded to the back side of the backing. The present invention also provides for a method of reducing the number of microbes located upon a topical skin surface of a mammal, as well as a method of preventing the transmission of a communicable disease capable of being transmitted by physical contact. The methods include topically contacting a skin surface of the mammal with the back side of the topical adhesive patch.
摘要翻译： 本发明提供了一种局部粘合贴剂，其包括具有前侧和背侧的背衬; 与背衬的前侧接触的制剂，所述制剂包括粘合剂; 和至少一种抗微生物剂。 抗菌剂一体地结合到背衬的背面。 本发明还提供了减少位于哺乳动物的局部皮肤表面上的微生物数量的方法，以及防止通过物理接触传播的传染病的传播方法。 所述方法包括将哺乳动物的皮肤表面局部接触局部粘合贴片的背面。
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公开(公告)号：US20100114057A1
公开(公告)日：2010-05-06
申请号：US12262866
申请日：2008-10-31
IPC分类号： A61J1/14
CPC分类号： A61M5/286 , A61M5/282 , A61M5/284 , A61M25/0068 , A61M25/0082
摘要： A container for housing a therapeutic agent includes a body member, a sealing element, and a rupturable membrane. The body member has a proximal end and a distal end and a lumen that extends from the proximal end to the distal end. The sealing element is slidably disposable in the lumen. The sealing element is configured to sealingly engage the body member as the element is slid within the lumen. The rupturable membrane is disposed across the lumen in proximity to the distal end of the body member.
摘要翻译： 用于容纳治疗剂的容器包括主体构件，密封元件和可破裂膜。 主体构件具有近端和远端以及从近端延伸到远端的内腔。 密封元件在内腔中可滑动地一次性使用。 密封元件构造成当元件在管腔内滑动时密封地接合主体构件。 可破裂膜跨过内腔设置在主体构件的远端附近。
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公开(公告)号：US20090233990A1
公开(公告)日：2009-09-17
申请号：US12263281
申请日：2008-10-31
申请人： Hee Cheol Cho , Eduardo Marban , Daniel Sigg
发明人： Hee Cheol Cho , Eduardo Marban , Daniel Sigg
CPC分类号： A61K31/7052 , C12N5/0657 , C12N2510/00 , C12N2799/022
摘要： Compositions and methods for enhancing hyperpolarization-activated cation inward current and disrupting inwardly rectifying potassium current of cells are described. The compositions and methods may be employed to cause the cells to become biological pacemaker cells, e.g. to become more like SA node cells, and to undergo spontaneous oscillating action potentials.
摘要翻译： 描述了增强超极化活化阳离子向内电流并破坏细胞内向整流钾电流的组合物和方法。 组合物和方法可以用于使细胞成为生物起搏细胞，例如， 变得更像SA节点细胞，并且经历自发的振荡动作电位。
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