利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

108 条记录 (耗时 0.028 秒)

    Rate control during AF using cellular intervention to modulate AV node
    2.
    发明授权
    Rate control during AF using cellular intervention to modulate AV node 有权
    使用细胞干预调整AV节点的AF期间的速率控制

    公开(公告)号：US08565898B2

    公开(公告)日：2013-10-22

    申请号：US11116621

    申请日：2005-04-28

    申请人： Vinod Sharma ,  Daniel C. Sigg

    发明人： Vinod Sharma ,  Daniel C. Sigg

    IPC分类号： A61N1/00 ,  A61K38/00 ,  A61K38/16

    CPC分类号： A61N1/362 ,  A61K9/0019 ,  A61K31/221 ,  A61K38/177 ,  A61N1/0568

    摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

    摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

    RATE CONTROL DURING AF USING CELLULAR INTERVENTION TO MODULATE AV NODE
    3.
    发明申请
    RATE CONTROL DURING AF USING CELLULAR INTERVENTION TO MODULATE AV NODE 审中-公开
    在使用细胞干扰调节AV节点的AF期间的速率控制

    公开(公告)号：US20120130303A1

    公开(公告)日：2012-05-24

    申请号：US13359949

    申请日：2012-01-27

    申请人： Vinod Sharma ,  Daniel C. Sigg

    发明人： Vinod Sharma ,  Daniel C. Sigg

    IPC分类号： A61K31/7052 ,  A61P9/00 ,  A61N1/362 ,  A61K35/00

    CPC分类号： A61N1/362 ,  A61K9/0019 ,  A61K31/221 ,  A61K38/177 ,  A61N1/0568

    摘要： A biologic intervention method and apparatus generates a persistent modification to an AV node that is physiologically stable after the agent has matured but is alterable with subsequent application of an agent. Specifically, the generic agent is used to modulate a node in a cardiac conduction system including rate control using one and a combination of a family of K+ channel or equivalent. Specifically, the channel is implemented to slow conduction by generating an outward current during optimization of action potential and repolarization phase thus decreasing the current that is available to excite downstream cells. A Kv 1.3 channel, for example, may be used as the biologic channel. The invention enables reversal of the modulation or adjustment for various heart rates (BPM) based on medical and patient-specific needs.

    摘要翻译： 生物干预方法和装置对于在该药剂已经成熟但随后随后施用药剂而可变化的生理稳定的AV节点产生持久性修饰。 具体地，通用代理用于调制心脏传导系统中的节点，包括使用一个K +通道或等效物系的组合的速率控制。 具体地，通过在动作电位和复极相优化期间产生向外的电流来实现缓慢传导，从而减少可用于激发下游单元的电流。 例如，可以使用Kv1.3通道作为生物通道。 本发明能够根据医疗和患者特定的需要逆转各种心率（BPM）的调节或调整。

    ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS
    5.
    发明申请
    ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 有权
    电子与生物学系统

    公开(公告)号：US20080103537A1

    公开(公告)日：2008-05-01

    申请号：US11554770

    申请日：2006-10-31

    申请人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    发明人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    IPC分类号： A61N1/00

    CPC分类号： A61N1/362 ,  A61N1/3627

    摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

    摘要翻译： 心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。 当植入时，主起搏器产生调节心脏功能的主要起搏刺激。 当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。 心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

    Electronic and biological pacemaker systems
    7.
    发明授权
    Electronic and biological pacemaker systems 有权
    电子和生物起搏器系统

    公开(公告)号：US07778705B2

    公开(公告)日：2010-08-17

    申请号：US11554770

    申请日：2006-10-31

    申请人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    发明人： Daniel C. Sigg ,  Timothy G. Laske ,  Vinod Sharma ,  Orhan Soykan

    IPC分类号： A61N1/00

    CPC分类号： A61N1/362 ,  A61N1/3627

    摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.

    摘要翻译： 心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。 当植入时，主起搏器产生调节心脏功能的主要起搏刺激。 当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。 心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

    Acoustic based cough detection
    8.
    发明授权
    Acoustic based cough detection 有权
    声学咳嗽检测

    公开(公告)号：US08777874B2

    公开(公告)日：2014-07-15

    申请号：US13114838

    申请日：2011-05-24

    申请人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

    发明人： Xusheng Zhang ,  Vinod Sharma ,  Eduardo N. Warman

    IPC分类号： A61B7/00

    CPC分类号： A61B5/0823 ,  A61B5/0205 ,  A61B5/11 ,  A61B5/686 ,  A61B2562/0204 ,  A61B2562/0219 ,  A61N1/3621 ,  A61N1/3627

    摘要： The present disclosure is directed to the detection of coughs and coughing episodes using acoustic signals. In various examples, an implantable medical device processes an acoustic signal obtained from an acoustic sensor to determine whether a patient has coughed. In some examples, the implantable medical device also performs a cough severity assessment. In some examples, the cough severity assessment may include a determination of the depth of the cough, the duration of the coughing episode, or whether the cough was wet or dry.

    摘要翻译： 本公开涉及使用声信号检测咳嗽和咳嗽发作。 在各种示例中，可植入医疗装置处理从声传感器获得的声信号，以确定患者是否已经咳嗽。 在一些示例中，可植入医疗装置还执行咳嗽严重度评估。 在一些实例中，咳嗽严重度评估可以包括确定咳嗽的深度，咳嗽发作的持续时间，或者咳嗽是湿还是干燥。

    Compositions and Methods to Treat Cardiac Pacing Conditions
    9.
    发明申请
    Compositions and Methods to Treat Cardiac Pacing Conditions 有权
    心脏起搏条件的组合和方法

    公开(公告)号：US20110300107A1

    公开(公告)日：2011-12-08

    申请号：US13096135

    申请日：2011-04-28

    申请人： Vinod Sharma ,  Xiaohong Qiu

    发明人： Vinod Sharma ,  Xiaohong Qiu

    IPC分类号： A61K31/7088 ,  A61P9/00 ,  C12N5/10 ,  A61K35/00

    CPC分类号： C12N15/86 ,  A61K35/13 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N2750/14143

    摘要： The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.

    摘要翻译： 该方法可以包括向有需要的受试者施用有效量的HCN多核苷酸。 HCN多核苷酸包括编码具有通道活性的HCN多肽的核苷酸序列。 HCN多肽的氨基酸序列和参考多肽的氨基酸序列具有至少80％的同一性，其中参考多肽以选自氨基酸92-214的氨基酸开始，并以选自氨基酸的氨基酸结束 SEQ ID NO：8的723-1188。 参考多肽的实例是SEQ ID NO：8的氨基酸214-723。 HCN多核苷酸可以是DNA或RNA。

    Method and apparatus for independent piezoelectric excitation in the micro-actuator assemblies of a hard disk drive for improved drive reliability
    10.
    发明申请
    Method and apparatus for independent piezoelectric excitation in the micro-actuator assemblies of a hard disk drive for improved drive reliability 审中-公开
    用于硬盘驱动器的微致动器组件中的独立压电激励的方法和装置，用于提高驱动可靠性

    公开(公告)号：US20090034128A1

    公开(公告)日：2009-02-05

    申请号：US11897936

    申请日：2007-08-31

    申请人： Vinod Sharma ,  Hyung Jai Lee

    发明人： Vinod Sharma ,  Hyung Jai Lee

    IPC分类号： G11B21/24

    CPC分类号： G11B5/4826 ,  G11B5/4873 ,  G11B5/5552

    摘要： A hard disk drive using a micro-actuator assembly to position a slider over a track on a rotating disk surface. The micro-actuator assembly includes a first piezoelectric device and a second piezoelectric device, both mechanically coupled to the slider. The first piezoelectric device includes a first terminal electrically coupled to a first voltage line and a second terminal electrically coupled to a ground line. The second piezoelectric device includes a third terminal electrically coupled to a ground line and a fourth terminal electrically coupled to a voltage line. A voltage applied to the first voltage line stimulates only the first piezoelectric device to alter a lateral position of the slider over the rotating disk surface, and a second voltage applied to the second voltage line stimulates only the second piezoelectric device to alter the lateral position of the slider over the rotating disk surface.

    摘要翻译： 使用微型致动器组件的硬盘驱动器将滑块定位在旋转盘表面上的轨道上。 微致动器组件包括机械地联接到滑块的第一压电装置和第二压电装置。 第一压电器件包括电耦合到第一电压线的第一端子和电耦合到接地线的第二端子。 第二压电器件包括电耦合到接地线的第三端子和电耦合到电压线的第四端子。 施加到第一电压线的电压仅刺激第一压电装置来改变滑块在旋转盘表面上的横向位置，并且施加到第二电压线的第二电压仅刺激第二压电装置改变第二压电装置的横向位置 滑块越过旋转盘表面。