公开(公告)号：US20160258968A1

公开(公告)日：2016-09-08

申请号：US15028667

申请日：2014-10-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Abhishek Jain ,  Anna Waterhouse ,  Mike Super ,  Donald E. Ingber ,  Daniel C. Leslie

IPC: G01N33/86 ,  B01L3/00 ,  G06F19/24

CPC classification number: B01L3/50273 ,  B01L3/502746 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0478 ,  B01L2400/084 ,  G01N33/4905 ,  G01N33/86 ,  G06F19/24

Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.

Abstract translation: 根据一个方面，提供了限定多个微通道的微流体凝固评估装置，其中血液样本以基本恒定的流速被驱动通过微通道，并且控制器被配置为结合定时器和压力感测 装置，在流动开始时确定第一压力值（或流量值），其中第二压力值大约是所确定的第一压力值的两倍的第一时间（Tpg），以及第二时间（Tpf） 压力值约为所确定的第一压力值的（1 + e）倍，并建立预测通道阻塞的对象凝固模型。 在另一方面，血液样本以基本上恒定的压力驱动通过微通道，并且控制器被配置为结合定时器和流量检测装置基于流量进行确定。

公开(公告)号：US09562914B2

公开(公告)日：2017-02-07

申请号：US15028667

申请日：2014-10-16

Applicant: President and Fellows of Harvard College

Inventor： Abhishek Jain ,  Anna Waterhouse ,  Mike Super ,  Donald E. Ingber ,  Daniel C. Leslie

IPC: G01N33/49 ,  G01N33/86 ,  B01L3/00 ,  G06F19/24

CPC classification number: B01L3/50273 ,  B01L3/502746 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0478 ,  B01L2400/084 ,  G01N33/4905 ,  G01N33/86 ,  G06F19/24

Abstract: In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.

Abstract translation: 根据一个方面，提供了限定多个微通道的微流体凝固评估装置，其中血液样本以基本恒定的流速被驱动通过微通道，并且控制器被配置为结合定时器和压力感测 装置，在流动开始时确定第一压力值（或流量值），其中第二压力值大约是所确定的第一压力值的两倍的第一时间（Tpg），以及第二时间（Tpf） 压力值约为所确定的第一压力值的（1 + e）倍，并建立预测通道阻塞的对象凝固模型。 在另一方面，血液样本以基本上恒定的压力驱动通过微通道，并且控制器被配置为结合定时器和流量检测装置基于流量进行确定。

公开(公告)号：US20180185839A1

公开(公告)日：2018-07-05

申请号：US15862621

申请日：2018-01-04

Applicant: President and Fellows of Harvard College

Inventor： Abhishek Jain ,  Anna Waterhouse ,  Mike Super ,  Donald E. Ingber ,  Daniel C. Leslie

IPC: B01L3/00 ,  G06F19/24 ,  G01N33/49 ,  G01N33/86

CPC classification number: B01L3/50273 ,  B01L3/502746 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0478 ,  B01L2400/084 ,  G01N33/4905 ,  G01N33/86 ,  G16B40/00

Abstract: A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom.

公开(公告)号：US20170100714A1

公开(公告)日：2017-04-13

申请号：US15393596

申请日：2016-12-29

Applicant: President and Fellows of Harvard College

Inventor： Abhishek Jain ,  Anna Waterhouse ,  Mike Super ,  Donald E. Ingber ,  Daniel C. Leslie

IPC: B01L3/00 ,  G01N33/49 ,  G06F19/24 ,  G01N33/86

CPC classification number: B01L3/50273 ,  B01L3/502746 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0478 ,  B01L2400/084 ,  G01N33/4905 ,  G01N33/86 ,  G16B40/00

Abstract: A microfluidic coagulation assessment device includes a plurality of microchannels, with a blood sample driven through the microchannels at a substantially constant flow rate. A controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom.