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    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices
    1.
    发明申请
    Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
    纳入生物活性的医疗器械及其制备方法

    公开(公告)号：US20120027819A1

    公开(公告)日：2012-02-02

    申请号：US13251821

    申请日：2011-10-03

    申请人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    发明人： Andrew P. Isch ,  Patrick H. Ruane ,  Waleska Pérez-Segarra

    IPC分类号： A61K9/00 ,  A61P23/00 ,  A61F2/82 ,  A61K31/445

    CPC分类号： A61L31/16 ,  A61L2300/402

    摘要： One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.

    摘要翻译： 一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点 与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是 麻药。 另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。 另一方面提供了制造这种装置的方法。

    Mandrel and method for coating open-cell implantable endovascular structures
    2.
    发明授权
    Mandrel and method for coating open-cell implantable endovascular structures 有权
    用于涂层开放细胞可植入血管内结构的心轴和方法

    公开(公告)号：US08092864B2

    公开(公告)日：2012-01-10

    申请号：US12199189

    申请日：2008-08-27

    申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    IPC分类号： B05D3/00

    CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

    摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

    摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

    MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES
    3.
    发明申请
    MANDREL AND METHOD FOR COATING OPEN-CELL IMPLANTABLE ENDOVASCULAR STRUCTURES 有权
    用于涂覆开放细胞可植入性内膜结构的方法和方法

    公开(公告)号：US20090061072A1

    公开(公告)日：2009-03-05

    申请号：US12199189

    申请日：2008-08-27

    申请人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    发明人： Andrew P. Isch ,  Jeff P. Little ,  Patrick H. Ruane

    IPC分类号： B05D5/00

    CPC分类号： B05D1/02 ,  A61F2/88 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B05D1/002 ,  C08L67/04

    摘要： Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device. Improved coating uniformity may be achieved by providing an annular space between the luminal surface of the medical device and an axial member. Coating on the luminal surface may be minimized by providing an axial member having an outer diameter that is greater than the maximum width or length of the spray contacting the axial member after passing through the openings in the medical device.

    摘要翻译： 提供涂覆医疗装置的方法以改善涂层的均匀性并减少涂层不规则，同时减少医疗装置的腔表面的直接涂覆。 优选地，涂覆管状医疗装置的方法包括以下步骤：将管状医疗装置定位在心轴涂层组件周围，将管状医疗装置安装在心轴涂层组件上，并将包括治疗剂和溶剂的包衣溶液喷涂在腹腔镜 安装在心轴涂层组件上的管状医疗装置的表面。 心轴涂层组件可以包括直径小于管状医疗装置的内腔的直径的轴向构件，以及从轴向构件延伸到外表面的至少一个环形凸起，该外表面的直径大于或基本上等于 医疗装置的管腔直径。 可以通过在医疗装置的腔表面和轴向构件之间提供环形空间来实现改进的涂层均匀性。 通过提供具有大于在穿过医疗装置中的开口之后接触轴向构件的喷雾器的最大宽度或长度的外径的轴向构件，腔体表面上的涂层可以最小化。

    Methods of manufacturing and modifying taxane coatings for implantable medical devices
    9.
    发明授权
    Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
    制造和修饰可植入医疗器械的紫杉烷涂层的方法

    公开(公告)号：US07875284B2

    公开(公告)日：2011-01-25

    申请号：US11823283

    申请日：2007-06-27

    申请人： Priscilla Reyes ,  William F. Moore ,  Randy Joe Myers ,  Patrick H. Ruane ,  Melinda S. Morrell

    发明人： Priscilla Reyes ,  William F. Moore ,  Randy Joe Myers ,  Patrick H. Ruane ,  Melinda S. Morrell

    IPC分类号： A61F2/00

    CPC分类号： A61K31/335 ,  A61F2/0095 ,  A61F2/91 ,  A61F2250/0067 ,  A61F2250/0091

    摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.

    摘要翻译： 本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。 特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。 优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率 。

    Use of Plasma in Formation of Biodegradable Stent Coating
    10.
    发明申请
    Use of Plasma in Formation of Biodegradable Stent Coating 审中-公开
    等离子体在生物降解性支架涂层形成中的应用

    公开(公告)号：US20110093056A1

    公开(公告)日：2011-04-21

    申请号：US12977472

    申请日：2010-12-23

    申请人： Stephen L. Kaplan ,  Patrick H. Ruane ,  Eric A. Lang ,  Torsten Kimura

    发明人： Stephen L. Kaplan ,  Patrick H. Ruane ,  Eric A. Lang ,  Torsten Kimura

    IPC分类号： A61F2/84 ,  C23C16/50 ,  A61F2/82

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/826 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2210/0004 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  B05B13/0228 ,  B05B13/0442 ,  Y10T428/1352

    摘要： Metallic stents are treated with a gaseous species in a plasma state under conditions causing the species to polymerize and to be deposited in polymerized form on the metallic stent surface prior to the application of a drug-polymer mixture, which is done by conventional non-plasma deposition methods. The drug-polymer mixture once applied forms a coating on the stent surface that releases the drug in a time-release manner and gradually erodes, leaving only the underlying plasma-deposited polymer. In certain cases, the plasma-deposited polymer itself erodes or dissolves into the physiological medium over an extended period of time, leaving only the metallic stent. While the various polymers and drug remain on the stent, the plasma-deposited polymer enhances the adhesion of the drug-polymer anchor coating and maintains the coating intact upon exposure to the mechanical stresses encountered during stent deployment.

    摘要翻译： 在施加药物 - 聚合物混合物之前，在等离子体状态下，使物质聚合并以聚合形式沉积在金属支架表面上的条件下，处于等离子体状态的金属支架，其通过常规非等离子体 沉积方法。 一次施用的药物 - 聚合物混合物在支架表面上形成涂层，其以时间释放方式释放药物并逐渐侵蚀，仅留下下面的等离子体沉积聚合物。 在某些情况下，等离子体沉积的聚合物本身在延长的时间内侵蚀或溶解到生理介质中，仅留下金属支架。 虽然各种聚合物和药物保留在支架上，等离子体沉积的聚合物增强了药物 - 聚合物锚固涂层的粘附，并且在暴露于支架展开期间遇到的机械应力的同时保持涂层完整。