公开(公告)号：US11209394B2

公开(公告)日：2021-12-28

申请号：US16319410

申请日：2017-07-26

Applicant: QORVO US, INC.

Inventor： Thayne L. Edwards ,  Florian Bell ,  Matthew Ryder ,  Bruce Murdock

IPC: G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/24 ,  G01N29/32 ,  B01L3/00 ,  H03H9/17

Abstract: A cartridge for sample handling and sensing includes (i) a sample port; (ii) a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and (iii) a second fluid port connected to the sample reservoir via a second fluid channel. The cartridge includes (i) a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator; and (ii) a fluid valve between the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.

公开(公告)号：US20200256881A9

公开(公告)日：2020-08-13

申请号：US16319412

申请日：2017-07-25

Applicant: QORVO US, INC.

Inventor： Florian Bell ,  Bruce Murdock

IPC: G01N33/86 ,  G01N15/06 ,  G01N29/02 ,  G01N29/036 ,  G01N33/49

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

公开(公告)号：US20190250176A1

公开(公告)日：2019-08-15

申请号：US16319412

申请日：2017-07-25

Applicant: QORVO US, INC.

Inventor： Florian Bell ,  Bruce Murdock

IPC: G01N33/86 ,  G01N15/06 ,  G01N29/02 ,  G01N29/036 ,  G01N33/49

CPC classification number: G01N33/86 ,  B01L3/502715 ,  B01L2300/023 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0436 ,  G01N11/10 ,  G01N11/16 ,  G01N15/0637 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N30/96 ,  G01N33/4905 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2203/0089 ,  G01N2203/0092 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/106

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

公开(公告)号：US20170261503A1

公开(公告)日：2017-09-14

申请号：US15453433

申请日：2017-03-08

Applicant: Qorvo US, Inc.

Inventor： Bruce Murdock ,  Rio Rivas

IPC: G01N33/543 ,  G01N29/02 ,  H01L41/22 ,  H01L41/113 ,  H01L41/187

CPC classification number: G01N33/54386 ,  G01N29/022 ,  G01N29/222 ,  G01N33/5438 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  H01L41/1132 ,  H01L41/187 ,  H01L41/22 ,  H03H9/175

Abstract: A fluidic device includes a base structure including at least one bulk acoustic wave (BAW) resonator structure having a fluidic passage containing at least one functionalized active region overlaid with functionalization material suitable to bind an analyte. One or more of a wall structure, a cover structure, or a portion of the base structure defining the fluidic passage includes additional functionalization material to form at least one absorber configured to bind at least one analyte. The dynamic measurement range of a BAW resonator structure is increased when the at least one absorber is placed upstream of the at least one functionalized active region.

公开(公告)号：US10578614B2

公开(公告)日：2020-03-03

申请号：US15453433

申请日：2017-03-08

Applicant: Qorvo US, Inc.

Inventor： Bruce Murdock ,  Rio Rivas

IPC: G01N33/543 ,  G01N29/02 ,  H01L41/113 ,  H01L41/187 ,  H01L41/22

Abstract: A fluidic device includes a base structure including at least one bulk acoustic wave (BAW) resonator structure having a fluidic passage containing at least one functionalized active region overlaid with functionalization material suitable to bind an analyte. One or more of a wall structure, a cover structure, or a portion of the base structure defining the fluidic passage includes additional functionalization material to form at least one absorber configured to bind at least one analyte. The dynamic measurement range of a BAW resonator structure is increased when the at least one absorber is placed upstream of the at least one functionalized active region.

公开(公告)号：US20190234907A1

公开(公告)日：2019-08-01

申请号：US16319410

申请日：2017-07-26

Applicant: QORVO US, INC.

Inventor： Thayne L. Edwards ,  Florian Bell ,  Matthew Ryder ,  Bruce Murdock

IPC: G01N29/02 ,  G01N29/22 ,  G01N29/24 ,  G01N29/32 ,  G01N29/036 ,  B01L3/00

CPC classification number: G01N29/022 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0688 ,  B01L2400/088 ,  G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N29/222 ,  G01N29/2437 ,  G01N29/32 ,  G01N2291/014 ,  G01N2291/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2291/106 ,  H03H9/175

Abstract: A cartridge for sample handling and sensing includes a sample port connected to a sample reservoir having a proximal end, a proximal region adjacent the proximal end, and a distal end opposite of the proximal end. The cartridge also includes a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and a second fluid port connected to the sample reservoir in the proximal region via a second fluid channel. In addition, the cartridge includes a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator. The cartridge further includes a fluid valve between the distal end of the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.