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1.发明申请METHODS FOR DETECTING DIHYDROXYVITAMIN D METABOLITES BY MASS SPECTROMETRY 审中-公开通过质谱法检测二羟基维生素D代谢物的方法公开(公告)号：US20140234989A1
公开(公告)日：2014-08-21
申请号：US14267014
申请日：2014-05-01
Applicant: Quest Diagnostics Investments Incorporated
Inventor： Brett HOLMQUIST , Nigel J. CLARKE , Anne Caston-Balderrama , Richard E. Reitz
IPC: G01N33/82
CPC classification number: G01N27/62 , G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
Abstract translation: 提供了使用质谱法检测样品中二羟基维生素D代谢物的存在或量的方法。 所述方法通常包括将样品中的二氢维生素D代谢物离子化并检测离子的量以确定样品中维生素D代谢物的存在或量。 在某些优选的实施方案中，所述方法包括在质谱法之前免疫促进二羟维生素D代谢物。 还提供了在单个测定中检测两种或更多种二羟维生素D代谢物的存在或量的方法。
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公开(公告)号：US20230146212A1
公开(公告)日：2023-05-11
申请号：US18091726
申请日：2022-12-30
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
CPC classification number: G01N33/82 , G01N30/7233 , H01J49/004 , H01J49/145 , G01N2030/009
Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US20230266347A1
公开(公告)日：2023-08-24
申请号：US18142153
申请日：2023-05-02
Applicant: Quest Diagnostics Investments Incorporated
Inventor： Brett HOLMQUIST , Nigel CLARKE , Anne Caston , Richard E. Reitz
IPC: G01N33/82
CPC classification number: G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
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公开(公告)号：US20170115314A1
公开(公告)日：2017-04-27
申请号：US15194009
申请日：2016-06-27
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
CPC classification number: G01N33/82 , G01N30/7233 , G01N2030/009 , G01N2030/027 , G01N2030/8813 , H01J49/004 , H01J49/145
Abstract: The invention relates to the detection of vitamin D. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D by mass spectrometry.
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公开(公告)号：US20220214366A1
公开(公告)日：2022-07-07
申请号：US17700320
申请日：2022-03-21
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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Patent Agency Ranking
公开(公告)号：US20210349109A1
公开(公告)日：2021-11-11
申请号：US17208564
申请日：2021-03-22
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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公开(公告)号：US20170261523A1
公开(公告)日：2017-09-14
申请号：US15362210
申请日：2016-11-28
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
IPC: G01N33/82
CPC classification number: G01N33/82 , G01N33/6848 , G01N33/6851 , G01N2560/00 , H01J49/00 , H01J49/0027 , Y10T436/212
Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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公开(公告)号：US20210041464A1
公开(公告)日：2021-02-11
申请号：US17001425
申请日：2020-08-24
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US20180348236A1
公开(公告)日：2018-12-06
申请号：US16051849
申请日：2018-08-01
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US20160061848A1
公开(公告)日：2016-03-03
申请号：US14715153
申请日：2015-05-18
Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
Inventor： Brett HOLMQUIST , Nigel CLARKE
CPC classification number: G01N33/82 , G01N33/6848 , G01N33/6851 , G01N2560/00 , H01J49/00 , H01J49/0027 , Y10T436/212
Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.
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