公开(公告)号：US20220291228A1

公开(公告)日：2022-09-15

申请号：US17827333

申请日：2022-05-27

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel CLARKE ,  Zhaohui CHEN

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74 ,  H01J49/04 ,  C07K14/625 ,  C07K1/16 ,  B01D15/08 ,  C07K1/14 ,  C07K14/62 ,  G01N33/543

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US20190212317A1

公开(公告)日：2019-07-11

申请号：US15830812

申请日：2017-12-04

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel CLARKE

IPC: G01N33/15 ,  H01J49/00 ,  H01J49/10 ,  G01N33/94 ,  G01N33/49 ,  G01N30/72

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/48 ,  G01N33/49 ,  G01N33/94 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/10 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein determine the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein determine the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

公开(公告)号：US20230146212A1

公开(公告)日：2023-05-11

申请号：US18091726

申请日：2022-12-30

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14

CPC classification number: G01N33/82 ,  G01N30/7233 ,  H01J49/004 ,  H01J49/145 ,  G01N2030/009

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US20210003588A1

公开(公告)日：2021-01-07

申请号：US17027267

申请日：2020-09-21

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel CLARKE ,  Zhaohui CHEN

IPC: G01N33/68 ,  G01N33/487 ,  G01N30/72 ,  G01N33/74

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US20220214366A1

公开(公告)日：2022-07-07

申请号：US17700320

申请日：2022-03-21

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82 ,  G01N30/72 ,  H01J49/00 ,  H01J49/14

Abstract: The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.

公开(公告)号：US20210349109A1

公开(公告)日：2021-11-11

申请号：US17208564

申请日：2021-03-22

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82 ,  G01N33/68 ,  H01J49/00

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US20170261523A1

公开(公告)日：2017-09-14

申请号：US15362210

申请日：2016-11-28

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82

CPC classification number: G01N33/82 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2560/00 ,  H01J49/00 ,  H01J49/0027 ,  Y10T436/212

Abstract: The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.

公开(公告)号：US20170212127A1

公开(公告)日：2017-07-27

申请号：US15457683

申请日：2017-03-13

Applicant: Quest Diagnostics Investments Incorporated

Inventor： Nigel CLARKE ,  Zhaohui CHEN

IPC: G01N33/68 ,  G01N30/72

CPC classification number: G01N33/6848 ,  G01N30/7266 ,  G01N33/487 ,  G01N33/74 ,  G01N2030/027 ,  G01N2333/62 ,  G01N2560/00 ,  H01J49/005 ,  H01J49/165 ,  H01J49/40

Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

公开(公告)号：US20160377636A1

公开(公告)日：2016-12-29

申请号：US15251224

申请日：2016-08-30

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Midred GOLDMAN ,  Nigel CLARKE

IPC: G01N33/74 ,  H01J49/00 ,  G01N30/72

CPC classification number: G01N33/743 ,  G01N30/724 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2458/15 ,  H01J49/00 ,  H01J49/0027

Abstract: Methods are provided for detecting the amount of one or more HRT panel analytes (i.e., estrone (E1), estrone sulfate (E1s), 17α-estradiol (E2a), 17β-estradiol (E2b), estradiol sulfate (E2s), estriol (E3), equilin (EQ), 17α-dihydroequilin (EQa), 17β-dihydroequilin (EQb), Equilenin (EN), 17α-dihydroequilenin (ENa), 17β-dihydroequilenin (ENb), and Δ8,9-dehydroestrone (dE1)) in a sample by mass spectrometry. The methods generally involve ionizing one or more HRT panel analytes in a sample and quantifying the generated ions to determine the amount of one or more HRT panel analytes in the sample. In methods where amounts of multiple HRT panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.

Abstract translation: 提供了用于检测一种或多种HRT面板分析物（即雌酮（E1），硫酸雌酮（E1s），17α-雌二醇（E2a），17β-雌二醇（E2b）），硫酸雌二醇（E2s），雌三醇 E3），平衡（EQ），17α-二氢等位基因（EQa），17β-二氢比例蛋白（EQb），平衡蛋白（EN），17α-二氢马来西林（ENa），17β-二氢马来西林（ENb）和Δ8,9-脱氢雌酮（dE1） ）在样品中通过质谱法测定。 所述方法通常涉及将样品中的一种或多种HRT面板分析物离子化并量化产生的离子以确定样品中一种或多种HRT面板分析物的量。 在检测到多个HRT面板分析物的量的方法中，在相同的样品注入中检测到多种分析物的量。

公开(公告)号：US20150323513A1

公开(公告)日：2015-11-12

申请号：US14710311

申请日：2015-05-12

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Nigel CLARKE

IPC: G01N33/15 ,  H01J49/00

CPC classification number: G01N33/15 ,  G01N30/7233 ,  G01N33/48 ,  G01N33/49 ,  G01N33/94 ,  H01J49/00 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/10 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein comprise determining the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

Abstract translation: 提供了通过质谱法测定样品中他莫昔芬及其代谢物的量的方法。 在一些方面，本文提供的方法包括确定去甲肾上腺素的量。 在一些方面，本文提供的方法包括确定去甲肾上腺素和他莫昔芬的量。 在一些方面，本文提供的方法包括确定奈多芬芬和其他他莫昔芬代谢物的量。 在一些方面，本文提供的方法包括测定他莫昔芬，去甲肾上腺素和其他他莫昔芬代谢物的量。