公开(公告)号：USD904089S1

公开(公告)日：2020-12-08

申请号：US29746351

申请日：2020-08-13

申请人： Qi Chen

设计人： Qi Chen

公开(公告)号：US08691825B2

公开(公告)日：2014-04-08

申请号：US13262096

申请日：2010-03-29

申请人： Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

发明人： Qi Chen ,  Mingxiang Cui ,  Bin Hu ,  Shuangxi Hu ,  Zhifa Pu ,  Philip E. Sanderson ,  Richard Soll ,  Xue Tang ,  Jiabing Wang ,  Yongjin Yan ,  Jinfeng Yao ,  Hongjie Zhang

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC分类号： A61K31/44 ,  C07D487/04

摘要： The instant invention provides for substituted fused pyrimidine compounds of Formula A that inhibit Akt activity: In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

摘要翻译： 本发明提供了抑制Akt活性的式A的取代的稠合嘧啶化合物：特别地，所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。

公开(公告)号：US20130121957A1

公开(公告)日：2013-05-16

申请号：US13465298

申请日：2012-05-07

申请人： Qi Chen ,  Omar D. Lopez ,  John A. Bender ,  Gan Wang ,  Van N. Nguyen ,  John F. Kadow ,  Nicholas A. Meanwell ,  Makonen Belema

发明人： Qi Chen ,  Omar D. Lopez ,  John A. Bender ,  Gan Wang ,  Van N. Nguyen ,  John F. Kadow ,  Nicholas A. Meanwell ,  Makonen Belema

IPC分类号： C07D403/14 ,  A61K45/06 ,  A61K31/4184 ,  A61K31/5377 ,  A61K31/4178 ,  C07D405/14

CPC分类号： C07D403/14 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/5377 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

公开(公告)号：US08288137B2

公开(公告)日：2012-10-16

申请号：US12946120

申请日：2010-11-15

申请人： Qi Chen ,  Qiong Cheng ,  Andrew C. Eliot ,  Kristin Ruebling-Jass

发明人： Qi Chen ,  Qiong Cheng ,  Andrew C. Eliot ,  Kristin Ruebling-Jass

IPC分类号： C12N1/21

CPC分类号： C12P7/20 ,  C12N9/93 ,  C12P7/18 ,  C12P7/42 ,  C12P7/52 ,  C12Y602/01001

摘要： Recombinant Escherichia coli (E. coli) bacteria that have enhanced acetyl-CoA synthetase activity and the ability to produce glycerol and glycerol-derived products, such as 3-hydroxypropionic acid, methylglyoxal, 1,2-propanediol, and 1,3-propanediol, are described. The recombinant E. coli comprise a promoter operably linked to a nucleotide sequence encoding a polypeptide having acetyl-CoA synthetase enzyme activity, wherein the promoter and nucleotide sequence are each independently either native or non-native.

摘要翻译： 具有增强的乙酰辅酶A合成酶活性和产生甘油和甘油衍生产物如3-羟基丙酸，甲基乙二醛，1,2-丙二醇和1,3-丙二醇的能力的重组大肠杆菌（E.coli）细菌 ，被描述。 重组大肠杆菌包含与编码具有乙酰辅酶A合成酶活性的多肽的核苷酸序列可操作地连接的启动子，其中启动子和核苷酸序列各自独立地是天然的或非天然的。

公开(公告)号：US20120214202A1

公开(公告)日：2012-08-23

申请号：US13164990

申请日：2011-06-21

申请人： Ritu Bhalla ,  Qi Chen ,  Qiong Cheng ,  Neeraj Pandey ,  Pierre E. Rouviere ,  Kristin Ruebling-Jass ,  Annapurna Sachan

发明人： Ritu Bhalla ,  Qi Chen ,  Qiong Cheng ,  Neeraj Pandey ,  Pierre E. Rouviere ,  Kristin Ruebling-Jass ,  Annapurna Sachan

IPC分类号： C12P21/06 ,  C12N1/21

CPC分类号： C12P21/02 ,  C12N1/02 ,  C12N9/1025 ,  C12N15/70

摘要： Methods are provided to obtain recombinant microbial cells having at least one genetic modification that increase the buoyant density of a recombinant microbial cell or the buoyant density of inclusion bodies produced within a recombinant microbial cell. Exemplified are genetic modifications that increase the buoyant density of a recombinant microbial cell expressing heterologous peptides and polypeptides. Increasing expression of the genes ysaB, glyQ, glyS or a combination thereof within the recombinant microbial cell produces cells or inclusion bodies having higher buoyant density. A similar effect was achieved by decreasing or disrupting expression of the endogenous gltA gene. Increases in buoyant density render peptide production more efficient with respect to time and costs.

摘要翻译： 提供了获得具有增加重组微生物细胞的浮力密度或在重组微生物细胞内产生的包涵体的浮力密度的至少一种遗传修饰的重组微生物细胞的方法。 示例是增加表达异源肽和多肽的重组微生物细胞的浮力密度的遗传修饰。 在重组微生物细胞内增加基因ysaB，glyQ，glyS或其组合的表达产生具有较高浮力密度的细胞或包涵体。 通过减少或破坏内源性gltA基因的表达也可以获得类似的效果。 浮力密度的增加使肽生产在时间和成本方面更有效率。

公开(公告)号：US20120195857A1

公开(公告)日：2012-08-02

申请号：US13198529

申请日：2011-08-04

申请人： Makonen Belema ,  Pothukanuri Srinivasu ,  John A. Bender ,  Omar D. Lopez ,  Qi Chen ,  Richard A. Rampulla ,  Samayamunthula Venkata Satya Arun Kumar Gupta ,  Nicholas A. Meanwell

发明人： Makonen Belema ,  Pothukanuri Srinivasu ,  John A. Bender ,  Omar D. Lopez ,  Qi Chen ,  Richard A. Rampulla ,  Samayamunthula Venkata Satya Arun Kumar Gupta ,  Nicholas A. Meanwell

IPC分类号： A61K31/4178 ,  C07D413/14 ,  A61K31/422 ,  C07D417/14 ,  A61K31/433 ,  A61P31/14 ,  A61K31/5025 ,  A61K31/7056 ,  A61K38/21 ,  A61K38/48 ,  A61K38/44 ,  A61K38/46 ,  C07D403/14 ,  C07D487/04

CPC分类号： C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

摘要翻译： 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

公开(公告)号：US20110281910A1

公开(公告)日：2011-11-17

申请号：US12942183

申请日：2010-11-09

申请人： Rico Lavoie ,  John A. Bender ,  Jeffrey Lee Romine ,  Edward H. Ruediger ,  Carol Bachand ,  Omar D. Lopez ,  Qi Chen ,  Makonen Belema ,  John F. Kadow ,  Lawrence G. Hamann

发明人： Rico Lavoie ,  John A. Bender ,  Jeffrey Lee Romine ,  Edward H. Ruediger ,  Carol Bachand ,  Omar D. Lopez ,  Qi Chen ,  Makonen Belema ,  John F. Kadow ,  Lawrence G. Hamann

IPC分类号： A61K31/4178 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  A61P31/14 ,  C07D407/14 ,  A61K31/427 ,  A61K31/422 ,  A61K31/4545 ,  C07D409/14 ,  C07D401/14

CPC分类号： C07D417/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/10 ,  C07D419/10 ,  C07D493/08

摘要： This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

摘要翻译： 本公开涉及式（I）的新化合物或说明书中定义的和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。

公开(公告)号：US20100090883A1

公开(公告)日：2010-04-15

申请号：US12308937

申请日：2007-06-14

申请人： Qi Chen ,  Tamas Bartfai ,  Armin Wendler

发明人： Qi Chen ,  Tamas Bartfai ,  Armin Wendler

IPC分类号： G01F23/284

CPC分类号： G01F23/284

摘要： An apparatus for ascertaining and/or monitoring fill level of a medium in a container. The apparatus includes an antenna, which transmits and receives high frequency signals in a predetermined oscillatory mode in a bounded space in a predetermined radiation direction, wherein, in front of the antenna in the radiation direction, an antenna protection element of a material transmissive for the high frequency signals is provided, and wherein a control/evaluation unit is provided, which evaluates the received high frequency signals and ascertains the fill level.

摘要翻译： 一种用于确定和/或监测容器中的介质的填充水平的装置。 该装置包括天线，其以预定的辐射方向在有界空间中以预定的振荡模式发送和接收高频信号，其中在辐射方向上的天线前面，透射天线的材料的天线保护元件 提供高频信号，并且其中提供控制/评估单元，其评估所接收的高频信号并确定填充水平。

公开(公告)号：US20090317996A1

公开(公告)日：2009-12-24

申请号：US12384005

申请日：2009-03-31

申请人： Zheng Dianging ,  Qi Chen

发明人： Zheng Dianging ,  Qi Chen

IPC分类号： H01R29/00

CPC分类号： F21V19/0005 ,  F21S4/10 ,  F21W2121/00 ,  H01R33/06 ,  H01R33/96

摘要： This utility model relates to a decorative light, and particularly, to a decorative light capable of avoiding an open circuit condition on an entire string of bulbs that operate in series when an individual bulb is removed. The decorative light comprises a socket, a bulb base, a bulb and two terminals, wherein the socket is provided with a retainer therein, which has an opening laterally extending therethrough, and an elastic, conductive ring or coil with a thickness smaller than a width of the opening is disposed within the opening. When the elastic ring or coil is in a natural state, the elastic ring extends outside the retainer through the opening at two sides of the retainer. The bulb base is further provided with an inserting partition at the bottom thereof The elastic conductive ring has two states: one is a separating state where the bulb base is inserted into the socket. In this first state, the inserting partition of the bulb base separates one side of the elastic ring or coil from the corresponding terminals. The other state is a conducting state of the two terminals when the bulb base is removed from the socket. In this second state both sides of the elastic, conductive ring or coil provide contact with the two terminals respectively. This utility model provides a decorative light capable of preventing failure of the complete string of bulbs when any bulb is removed.

摘要翻译： 本实用新型涉及一种装饰性光，特别涉及一种能够避免在单独灯泡被去除时串联操作的整个灯泡串上的开路状况的装饰灯。 装饰灯包括插座，灯泡基座，灯泡和两个端子，其中插座在其中设置有保持器，其具有横向延伸穿过的开口，以及具有小于宽度的弹性导电环或线圈 的开口设置在开口内。 当弹性环或线圈处于自然状态时，弹性环通过保持器两侧的开口延伸到保持器的外部。 灯泡底部还在其底部设置有插入隔板。弹性导电环具有两种状态：一种是灯泡基座插入插座的分离状态。 在该第一状态下，灯泡座的插入分隔部将弹性环或线圈的一侧与相应的端子分开。 另一种状态是当灯泡底座从插座中取出时两个端子的导通状态。 在该第二状态下，弹性导电环或线圈的两侧分别与两个端子分别接触。 该实用新型提供了一种装饰灯，能够在任何灯泡被移除时防止整个灯泡串失败。

公开(公告)号：US20090161105A1

公开(公告)日：2009-06-25

申请号：US11988279

申请日：2006-05-16

申请人： Qi Chen

发明人： Qi Chen

IPC分类号： G01J4/00

CPC分类号： G01F23/284

摘要： A method for ascertaining and monitoring the fill level of a medium in a container according to the travel-time measuring method, wherein, via a first coupling element of an antenna, high-frequency transmission signals are transmitted with a predetermined polarization plane (11) of the electric field, wherein the polarization plane of an electric field of the transmission signal is oriented essentially at a plane angle (θ) of approximately 45° to a plane (NL), which contains a propagation vector (kS) of the transmission signal and the surface normal of an inner wall of the container or the surface normal of a disturbance element in the container, and wherein the fill level is ascertained on the basis of the reflection signal coupled back into the first coupling element.

摘要翻译： 一种根据行驶时间测量方法确定和监视容器中的介质的填充水平的方法，其中，经由天线的第一耦合元件，以预定的偏振平面（11）传输高频传输信号， ，其中所述传输信号的电场的偏振面基本上以与包含所述传输信号的传播矢量（kS）的平面（NL）成大约45°的平面角（θ）定向 以及容器的内壁的表面法线或容器中的扰动元件的表面法线，并且其中基于耦合回第一耦合元件的反射信号来确定填充水平。