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公开(公告)号：US3499913A
公开(公告)日：1970-03-10
申请号：US3499913D
申请日：1968-01-03
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , JOLLY JEAN
IPC: C07J73/00 , C07D101/00 , C07C167/02 , C07C169/10
CPC classification number: C07J73/003
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2.发明授权13{62 -ethyl-17{60 -methyl-18,19-dinor-{66 {hu 4,9{b -pregnadiene-3,20-dione 失效13 {62 -ETHYL-17 {60-甲基-18,19-DINOR- {66 {HU 4,9 {B -PREGNADIENE-3,20-DIONE
公开(公告)号：US3919267A
公开(公告)日：1975-11-11
申请号：US51738074
申请日：1974-10-23
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN
IPC: A61K31/56
CPC classification number: Y10S514/859 , Y10S514/864
Abstract: HAVING EXCELLENT ANTI-ANDROGENIC ACTIVITY AND PROGESTOMIMETIC AND ANTI-ESTROGENIC ACTIVITY AND ITS PREPARATION.
13 Beta -ETHYL-17 Alpha -METHYL-18,19-DINOR- Delta 4,9PREGNADIENE-3,20-DIONE OF THE FORMULAAbstract translation: 13具有优异抗发生活性和原始和抗雌激素活性的配方的β-βHYL-17α-甲基-18,19-DINOR- DELTA 4,9-孕酮-3,20-二酮及其制备。
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公开(公告)号：US3919198A
公开(公告)日：1975-11-11
申请号：US43860274
申请日：1974-02-01
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN
IPC: C07D303/32 , A61K31/585 , A61P7/10 , A61P9/00 , B01J31/00 , C07C20060101 , C07D20060101 , C07J20060101 , C07J1/00 , C07J9/00 , C07J17/00 , C07J21/00 , C07J31/00 , C07J51/00
Abstract: The present invention relates to a dienic derivative of the androstane series having the formula
WHEREIN R is a member selected from the group consisting of hydrogen, alkyl having 1 to 4 carbon atoms and alkali metal, R'' and R'''' are members selected from the group consisting of 1) hydrogen and -COOM, respectively, where M is alkali metal, and 2) taken together, the divalent
group, R2 is a member selected from the group consisting of hydrogen and methyl, with the proviso when R is hydrogen or alkyl having 1 to 4 carbon atoms, R'' and R'''' together are the divalent
group; as well as their process of preparation.Abstract translation: 本发明涉及具有式WHEREIN R为选自氢，具有1至4个碳原子的烷基和碱金属的成员，R'和R“为选自以下的成员的雄甾烷系的二烯衍生物： 分别由1）氢和-COOM组成的组，其中M是碱金属，和2）合并在一起，二价-C-PARALLEL O基，R2是选自氢和甲基的成员，条件是 当R为氢或具有1至4个碳原子的烷基时，R'和R“一起为二价-C-PARALLEL O基; 以及他们的准备过程。
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Patent Agency Ranking4.发明授权3,5-diketals of 4,5 - seco-gonane-3,5,17-triones and process of preparation 失效4,5-SEON-GONANE-3,5,17-TRIONES的3,5-二硬脂酸酯和制备方法
公开(公告)号：US3591606A
公开(公告)日：1971-07-06
申请号：US3591606D
申请日：1967-05-23
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN , JOLY ROBERT
Abstract: WHEREIN R" IS LOWER ALKYL AND R"'' IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYLENE AND SUBSTITUTED LOWER ALKYLENE; AND A IS SELECTED FROM THE GROUP CONSISTING OF TWO HYDROGENS AND A DOUBLE BOND THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE TOTAL SYNTHESIS OF STEROIDS, PARTICULARLY THOSE HAVING SUBSTITUENTS ON THE 17 CARBON ATOM.
=C(-O-R")2 AND =C
WHREIN R'' REPRESENTS AN ALKYL HAVING FROM 1 TO 4 CARBON ATOMS; X REPRESENTS A MEMBER SELECTED FROM THE GROUP CONSISTING OF
X AND THE 9,11-POSITION IS A
3-(X=),13-R''-GON-4-EN-17-ONE WHERE C-4 IS REPLACED BY
THE PRESENT INVENTON RELATES TO 3,5-DIKETALS OF 4,5SECO-GONANE-3,517-TRIONES OF THE FORMULA-
5.发明授权3,5-Bis-ethylenedioxy-13{62 -alkyl-4,5-seco-{66 {hu 9,11{b -gonodiene-17-ones 失效3,5-双 - 亚乙二氧基-13 {62-烷基-4,5-仲 - {66 {hu 9,11 {b-亚二烯-17-酮
公开(公告)号：US3910961A
公开(公告)日：1975-10-07
申请号：US40017073
申请日：1973-09-24
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN
IPC: C07D317/72 , C07J1/00 , C07J75/00 , C07D317/26
CPC classification number: C07D317/72 , C07C2603/16 , C07J1/00 , C07J75/00
Abstract: Novel intermediates for the preparation of trienic steroids which intermediates have the formula
WHEREIN R is alkyl of one to four carbon atoms and X is selected from the group consisting of aliphatic of one to six carbon atoms optionally substituted and cycloalkyl of three to six carbon atoms and Y is selected from the group consisting of O and ethylenedioxy.Abstract translation: 用于制备三烯类固醇的新型中间体，其中间体具有式WHEREIN R为1-4个碳原子的烷基，X选自1-6个碳原子的任选取代的脂族基和3-6个碳原子的环烷基，以及 Y选自= O和亚乙二氧基。
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公开(公告)号：US3897417A
公开(公告)日：1975-07-29
申请号：US43860174
申请日：1974-02-01
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN
IPC: C07J31/00 , A61K31/585 , A61P7/10 , C07J21/00 , C07C173/00
CPC classification number: C07J21/00
Abstract: WHEREIN R is alkyl having 1 to 4 carbon atoms and R2 is defined above, with a thioalkanoic acid of the formula
WHEREIN R1 is a linear alkyl having 1 to 4 carbon atoms and R2 is hydrogen or methyl comprising the steps reacting a compound of the formula
The present invention relates to a process for the preparation of steroidal spirolactones having the formulaAbstract translation: 本发明涉及一种制备具有下式的甾族六酮的方法：其中R 1是具有1至4个碳原子的直链烷基，R 2是氢或甲基，包括使式WHEREIN R为具有1至 4个碳原子和R 2如上定义，与式R 1 COSH的硫代链烷酸，其中R 1如上定义，在中性介质中加热所得产物并回收所述甾体螺内酯; 以及中间体。
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7.发明授权Process for the production of 16alpha 17alpha-dihydroxy-19-nor-progesterone 失效生产16ALPHA 17ALPHA-DIHYDROX-19-NOR-PROGESTERONE的方法
公开(公告)号：US3637770A
公开(公告)日：1972-01-25
申请号：US3637770D
申请日：1969-12-31
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN , JOLY ROBERT
Abstract: A PROCESS FOR THE PRODUCTION OF 16A,17A-DIHYDROXY-19NOR-PROGESTERONE FROM A 3,5-IKETAL OF 4,5-SECO-ESTRANE3,5,17-TRIONE BY 17-CYANATION, 16-DEHYDRATION, METHYLATION, HYDROLYSIS OF THE KETALS, CYCLIZATION OF THE A RING AND HYDROXYLATION OF THE $16 BOND. THE INTERMEDIATES ARE ALSO PART OF THE DISCLOURE.
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公开(公告)号：US3424745A
公开(公告)日：1969-01-28
申请号：US45841665
申请日：1965-05-24
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , JOLLY JEAN , PROST-MARECHAL JACQUES , BUCOURT ROBERT , TESSIER JEAN
IPC: A61K31/565 , A61K31/566 , A61K31/567 , A61K31/57 , C07D295/04 , C07J1/00 , C07J5/00 , C07J7/00 , C07J41/00 , C07J75/00 , F16B35/06 , C07C173/10 , C07C169/10 , C07C169/34
CPC classification number: C07D295/04 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/57 , C07J1/00 , C07J5/00 , C07J7/00 , C07J41/00 , C07J75/00 , F16B35/06
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