公开(公告)号：US20230338533A1

公开(公告)日：2023-10-26

申请号：US17923070

申请日：2021-05-13

申请人： RXCELL INC.

发明人： Xianmin ZENG ,  Mahendra RAO

IPC分类号： A61K39/00 ,  A61P37/04 ,  A61K39/215

CPC分类号： A61K39/4633 ,  A61P37/04 ,  A61K39/461 ,  A61K39/215

摘要： Hypoimmunogenic cell lines useful in enhancing, invoking and/or stimulating an immune response and methods for their use and production are provided.

公开(公告)号：US20230374448A1

公开(公告)日：2023-11-23

申请号：US17913535

申请日：2021-04-06

申请人： RXCELL INC.

发明人： Xianmin ZENG ,  Mahendra RAO

IPC分类号： C12N5/0793 ,  C12N15/90 ,  C12N5/00 ,  C07K14/54 ,  C07K14/52

CPC分类号： C12N5/0619 ,  C12N5/062 ,  C12N15/907 ,  C12N5/0006 ,  C07K14/5428 ,  C07K14/521 ,  C12N2506/45 ,  C12N2509/00 ,  C12N2501/105 ,  C12N2501/41 ,  C12N2501/119

摘要： Hypoimmunogenic cell lines and methods and compositions for their production are provided.

公开(公告)号：US20240228951A1

公开(公告)日：2024-07-11

申请号：US18595503

申请日：2024-03-05

申请人： RXCELL INC.

发明人： Xianmin ZENG ,  Mahendra RAO

IPC分类号： C12N5/0735 ,  C12N5/071 ,  C12N5/0775 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797

CPC分类号： C12N5/0606 ,  C12N5/0619 ,  C12N5/0621 ,  C12N5/0622 ,  C12N5/0623 ,  C12N5/0668 ,  C12N5/067 ,  C12N2506/03

摘要： Methods are provided for generating multiple cellular products via differentiation of cells from single clinically compliant pluripotent cells into multiple cellular products selected from retinal epithelium, retinal progenitors, neural stem cells, dopaminergic neurons, astrocytes, hepatocytes, endothelial cells and mesenchymal cells using standard differentiation protocols for the multiple cellular products.