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公开(公告)号:US06562210B1
公开(公告)日:2003-05-13
申请号:US09475904
申请日:1999-12-30
IPC分类号: G01N27327
CPC分类号: C12Q1/001
摘要: According to an aspect of the invention, an electrochemical cell for analysis of a sample is provided, comprising a dual electrode having a dielectric strip with electrical conductors on opposite sides. According to a preferred embodiment, the electrochemical cell comprises a base, and a first reagent the proximate the dual electrode. According to a further preferred embodiment, a second reagent is provided proximate the dual electrode. A cover may also be provided comprising a sample aperture. According to a particularly preferred embodiment, the first and second reagents are superposed, and the dual electrode is between the first and second reagents. The dual electrode separates the two and preserves chemical stability until a sample is applied.
摘要翻译: 根据本发明的一个方面,提供了一种用于分析样品的电化学电池,包括具有在相对侧上具有电导体的介电条的双电极。 根据一个优选的实施方案,电化学电池包括基底和靠近双电极的第一试剂。 根据另一优选实施例,第二试剂设置在双电极附近。 还可以提供包括样品孔的盖。 根据特别优选的实施方案,第一和第二试剂叠加,双电极位于第一和第二试剂之间。 双电极分离两者并保持化学稳定性,直到施加样品。
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公开(公告)号:US07476827B1
公开(公告)日:2009-01-13
申请号:US10976740
申请日:2004-10-29
申请人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
发明人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
IPC分类号: B23K26/38
CPC分类号: G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要: The present invention relates to a method of forming a biosensor. The method includes providing a substrate coated with a electrically conductive material, ablating the electrically conductive material to form electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and applying a reagent to at least one of the electrodes.
摘要翻译: 本发明涉及形成生物传感器的方法。 该方法包括提供涂覆有导电材料的基材,烧蚀导电材料以形成电极和编码图案,其中在导电涂层和基板之间存在足够的对比度,使得代码图案是可辨别的,并且施加试剂 至少一个电极。
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公开(公告)号:US06540890B1
公开(公告)日:2003-04-01
申请号:US09704145
申请日:2000-11-01
IPC分类号: G01N27327
CPC分类号: G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要: A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a first surface coupled to the substrate and a second surface. The first surface is carved so that it includes a flow channel therein. The flow channel extends over at least a portion of the reagent. In addition, the cover includes secondary channels extending on either side of the channel.
摘要翻译: 提供了一种生物传感器,其包括基板,位于基板上的试剂和包括耦合到基板的第一表面和第二表面的盖。 雕刻第一表面,使其包括其中的流动通道。 流动通道延伸至至少一部分试剂。 此外,盖包括在通道的任一侧上延伸的次级通道。
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公开(公告)号:US07780827B1
公开(公告)日:2010-08-24
申请号:US11158772
申请日:2005-06-22
申请人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
发明人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
IPC分类号: G01N27/327
CPC分类号: G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要: The present invention relates to a biosensor. The biosensor includes a support substrate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译: 本发明涉及生物传感器。 所述生物传感器包括支撑衬底,位于所述支撑衬底上的导电涂层,所述涂层被形成以限定电极和编码图案,其中所述导电涂层和所述衬底之间存在足够的对比度,使得所述代码图案是可辨别的,以及 与所述支撑基板配合以限定通道的盖。 至少一部分电极定位在通道中。
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公开(公告)号:US20080314882A1
公开(公告)日:2008-12-25
申请号:US10976740
申请日:2004-10-29
申请人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, JR.
发明人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, JR.
IPC分类号: C12M3/00
CPC分类号: G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要: The present invention relates to a method of forming a biosensor. The method includes providing a substrate coated with a electrically conductive material, ablating the electrically conductive material to form electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and applying a reagent to at least one of the electrodes.
摘要翻译: 本发明涉及形成生物传感器的方法。 该方法包括提供涂覆有导电材料的基材,烧蚀导电材料以形成电极和编码图案,其中在导电涂层和基板之间存在足够的对比度,使得代码图案是可辨别的,并且施加试剂 至少一个电极。
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公开(公告)号:US07386937B2
公开(公告)日:2008-06-17
申请号:US11416497
申请日:2006-05-01
CPC分类号: G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要: A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译: 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料,并使用从基底的激光烧蚀部分地去除导电材料,使得小于90%的导电材料保留在基底上,并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。
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公开(公告)号:US06911621B2
公开(公告)日:2005-06-28
申请号:US10338498
申请日:2003-01-08
IPC分类号: G01N33/483 , B81B1/00 , G01N27/327 , G01N27/49 , G01N33/543 , B23K26/36
CPC分类号: G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要: A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.
摘要翻译: 提供了形成生物传感器的方法。 该方法包括提供基底和包括第一表面和第二表面的盖,将试剂放置在基底上,通过在第一表面中的激光烧蚀来雕刻通道,以及将盖的第一表面连接到第二表面。 通道包括具有第一高度的第一部分和具有小于第一高度的第二高度的第二部分。
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公开(公告)号:US06814844B2
公开(公告)日:2004-11-09
申请号:US09942515
申请日:2001-08-29
申请人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, Jr.
发明人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, Jr.
IPC分类号: G01N27327
CPC分类号: G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要: The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译: 本发明涉及生物传感器。 生物传感器包括支撑基底,位于支撑基底上的导电涂层,所述涂层被形成以限定电极和编码图案,其中导电涂层和基底之间存在足够的对比度,使得代码图案是可辨别的,以及 与所述支撑基板配合以限定通道的盖。 至少一部分电极定位在通道中。
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公开(公告)号:US20100219071A1
公开(公告)日:2010-09-02
申请号:US11158772
申请日:2005-06-22
申请人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, JR.
发明人: Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, JR.
IPC分类号: G01N33/50
CPC分类号: G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要: The present invention relates to a biosensor. The biosensor includes a support substrate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译: 本发明涉及生物传感器。 所述生物传感器包括支撑衬底,位于所述支撑衬底上的导电涂层,所述涂层被形成以限定电极和编码图案,其中所述导电涂层和所述衬底之间存在足够的对比度,使得所述编码图案是可辨别的,以及 与所述支撑基板配合以限定通道的盖。 至少一部分电极定位在通道中。
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公开(公告)号:US07073246B2
公开(公告)日:2006-07-11
申请号:US10601144
申请日:2003-06-20
IPC分类号: G01R3/00
CPC分类号: G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要: A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm.
摘要翻译: 提供制造生物传感器的方法。 生物传感器包括在基底上的导电材料和形成在基底上的电极图案,图案具有不同的特征尺寸。 使用宽场激光烧蚀部分地从基底去除导电材料,使得小于90%的导电材料保留在基底上,并且电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差小于约6um。
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