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公开(公告)号：US07386937B2
公开(公告)日：2008-06-17
申请号：US11416497
申请日：2006-05-01
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译： 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。
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公开(公告)号：US07073246B2
公开(公告)日：2006-07-11
申请号：US10601144
申请日：2003-06-20
IPC分类号： G01R3/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm.
摘要翻译： 提供制造生物传感器的方法。 生物传感器包括在基底上的导电材料和形成在基底上的电极图案，图案具有不同的特征尺寸。 使用宽场激光烧蚀部分地从基底去除导电材料，使得小于90％的导电材料保留在基底上，并且电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差小于约6um。
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公开(公告)号：US20090020502A1
公开(公告)日：2009-01-22
申请号：US12238023
申请日：2008-09-25
IPC分类号： H01B13/008
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08287703B2
公开(公告)日：2012-10-16
申请号：US12238023
申请日：2008-09-25
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08551308B2
公开(公告)日：2013-10-08
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US07867369B2
公开(公告)日：2011-01-11
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
发明人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
IPC分类号： G01N27/327
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译： 具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。 具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。 除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。 本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。
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公开(公告)号：US20090056120A1
公开(公告)日：2009-03-05
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
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公开(公告)号：USRE41309E1
公开(公告)日：2010-05-04
申请号：US10409721
申请日：2003-04-09
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N33/48
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。
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公开(公告)号：USRE42953E1
公开(公告)日：2011-11-22
申请号：US10008788
申请日：2001-12-07
申请人： William F. Crismore , Nigel A. Surridge , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho
发明人： William F. Crismore , Nigel A. Surridge , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho
IPC分类号： G01N33/48
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
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公开(公告)号：US06270637B1
公开(公告)日：2001-08-07
申请号：US09386210
申请日：1999-08-31
申请人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
发明人： William F. Crismore , Nigel A. Surridge , Daniel R. McMinn , Richard J. Bodensteiner , Eric R. Diebold , R. Dale Delk , David W. Burke , Jiaxiong Jason Ho , Robert Kitchel Earl , Brian A. Heald
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , Y10S435/817
摘要： An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
摘要翻译： 一种具有四个新特征的电化学生物传感器测试条。 测试条包括针对带样品应用端口的位置的触感的缩进。 样品应用端口通向包括测试试剂的毛细管测试室。 湿试剂包括约0.2重量％至约2重量％的聚环氧乙烷约100千道尔顿至约900千道尔顿的平均分子量，这使得干燥的试剂更具亲水性并且更坚固以进行剥离加工步骤，例如机械冲压，和 由测试用户进行机械操作。 毛细管测试室的屋顶包括透明或半透明的窗口，其作为“填充到这里”线，从而识别何时将足够的测试样品（液体样品，例如血液）添加到测试室以精确地执行 测试。 测试条还可以包括位于样品应用端口处的凹口。 缺口减少了称为“剂量犹豫”的现象。
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