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公开(公告)号：US07386937B2
公开(公告)日：2008-06-17
申请号：US11416497
申请日：2006-05-01
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译： 提供制造生物传感器的方法。 该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。 所述至少一个电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。
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公开(公告)号：US07073246B2
公开(公告)日：2006-07-11
申请号：US10601144
申请日：2003-06-20
IPC分类号： G01R3/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm.
摘要翻译： 提供制造生物传感器的方法。 生物传感器包括在基底上的导电材料和形成在基底上的电极图案，图案具有不同的特征尺寸。 使用宽场激光烧蚀部分地从基底去除导电材料，使得小于90％的导电材料保留在基底上，并且电极图案具有在两个点之间延伸的边缘。 边缘与两点之间延伸的线的标准偏差小于约6um。
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公开(公告)号：US06540890B1
公开(公告)日：2003-04-01
申请号：US09704145
申请日：2000-11-01
IPC分类号： G01N27327
CPC分类号： G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要： A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a first surface coupled to the substrate and a second surface. The first surface is carved so that it includes a flow channel therein. The flow channel extends over at least a portion of the reagent. In addition, the cover includes secondary channels extending on either side of the channel.
摘要翻译： 提供了一种生物传感器，其包括基板，位于基板上的试剂和包括耦合到基板的第一表面和第二表面的盖。 雕刻第一表面，使其包括其中的流动通道。 流动通道延伸至至少一部分试剂。 此外，盖包括在通道的任一侧上延伸的次级通道。
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公开(公告)号：US06911621B2
公开(公告)日：2005-06-28
申请号：US10338498
申请日：2003-01-08
IPC分类号： G01N33/483 , B81B1/00 , G01N27/327 , G01N27/49 , G01N33/543 , B23K26/36
CPC分类号： G01N33/5438 , G01N33/54366 , Y10T29/49002
摘要： A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.
摘要翻译： 提供了形成生物传感器的方法。 该方法包括提供基底和包括第一表面和第二表面的盖，将试剂放置在基底上，通过在第一表面中的激光烧蚀来雕刻通道，以及将盖的第一表面连接到第二表面。 通道包括具有第一高度的第一部分和具有小于第一高度的第二高度的第二部分。
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公开(公告)号：US06814843B1
公开(公告)日：2004-11-09
申请号：US09704235
申请日：2000-11-01
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed portion cooperates with the substrate to define a channel extending across the reagent.
摘要翻译： 提供一种生物传感器，其包括基板，位于基板上的试剂，以及包括顶侧和大致平坦的底侧的盖。 底侧联接到基底以限定密封部分和未密封部分。 未密封部分与衬底配合以限定穿过试剂的通道。
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公开(公告)号：US20090020502A1
公开(公告)日：2009-01-22
申请号：US12238023
申请日：2008-09-25
IPC分类号： H01B13/008
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08287703B2
公开(公告)日：2012-10-16
申请号：US12238023
申请日：2008-09-25
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US08551308B2
公开(公告)日：2013-10-08
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/327 , C12Q1/25 , H05K3/00
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译： 具有电极元件的电化学生物传感器具有光滑，高质量的边缘。 这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。 由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。 此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量 形成它们
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公开(公告)号：US07867369B2
公开(公告)日：2011-01-11
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
发明人： Raghbir S. Bhullar , Harvey B. Buck, Jr. , Brian S. Hill , Paul Douglas Walling , Terry A. Beaty , David W. Burke , Eric R. Diebold
IPC分类号： G01N27/327
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译： 具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。 具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。 除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。 本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。
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公开(公告)号：US20090056120A1
公开(公告)日：2009-03-05
申请号：US12238101
申请日：2008-09-25
IPC分类号： G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
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