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公开(公告)号：US4446234A
公开(公告)日：1984-05-01
申请号：US314477
申请日：1981-10-23
申请人： Raimondo Russo , Lance A. Liotta
发明人： Raimondo Russo , Lance A. Liotta
CPC分类号： A61L27/3604 , A61L27/38 , A61L27/3804 , C12N5/0068 , C12N5/0605 , C12N5/067 , G01N33/5011 , G01N33/5091 , A61L2430/40 , C12N2533/92
摘要： Amnion membranes derived from mammalian placentas are employed as the substrate tissue in in vitro assay methods for evaluating cellular interaction with natural barrier tissues. The amnion is also employed as a growth substrate, particularly for the culture of cells difficult to culture on conventional substrates. A diagnostic apparatus including an amnion membrane is also disclosed.
摘要翻译： 来自哺乳动物胎盘的羊膜被用作用于评价与天然屏障组织的细胞相互作用的体外测定方法中的底物组织。 羊膜也被用作生长底物，特别是对于常规底物难以培养的细胞的培养物。 还公开了一种包括羊膜的诊断装置。
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公开(公告)号：US4857643A
公开(公告)日：1989-08-15
申请号：US266559
申请日：1988-11-03
IPC分类号： A61K31/425 , A61K31/426 , A61K31/44 , A61K31/495 , A61P11/00 , A61P11/10 , A61P11/14 , C07C43/23 , C07C45/29 , C07C49/255 , C07D277/04 , C07D277/06 , C07D311/20 , C07D319/20 , C07D417/06 , C07D417/12 , C07D521/00
CPC分类号： C07D231/12 , C07C43/23 , C07C45/29 , C07C49/255 , C07D233/56 , C07D249/08 , C07D277/04 , C07D277/06 , C07D311/20 , C07D319/20 , C07D417/06
摘要： 2-Substituted thiazolidines compounds having formula I ##STR1## wherein X is a CH.sub.2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R.sub.1 is hydrogen or a group of formula ##STR2## R.sub.2 is hydrogen or a free or esterified carboxy group, R.sub.a and R.sub.b are hydrogen or methyl, p is zero or 1, R.sub.3 is hydrogen, a C.sub.1 -C.sub.2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.
摘要翻译： 2-取代的具有式I的噻唑烷化合物（I）其中X是CH 2，O或S，R是羟基或酰氧基，烷氧基，烯氧基或烷氧基，R 1是氢或式 是氢或游离或酯化的羧基，R a和R b是氢或甲基，p是0或1，R 3是氢，C 1 -C 2烷基磺酰基，苯基或对C 1 -C 6苯基，对甲基磺酰基或酰基 组; 可用作粘液调节，镇咳药和抗骨质疏松剂。
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公开(公告)号：US4798898A
公开(公告)日：1989-01-17
申请号：US755834
申请日：1985-07-17
IPC分类号： A61K31/425 , A61K31/426 , A61K31/44 , A61K31/495 , A61P11/00 , A61P11/10 , A61P11/14 , C07C43/23 , C07C45/29 , C07C49/255 , C07D277/04 , C07D277/06 , C07D311/20 , C07D319/20 , C07D417/06 , C07D417/12 , C07D521/00 , A61K31/38
CPC分类号： C07D231/12 , C07C43/23 , C07C45/29 , C07C49/255 , C07D233/56 , C07D249/08 , C07D277/04 , C07D277/06 , C07D311/20 , C07D319/20 , C07D417/06 , Y10S514/85
摘要： 2-Substituted thiazolidines compounds having formula I ##STR1## wherein X is a CH.sub.2, O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R.sub.1 is hydrogen or a group of formula ##STR2## R.sub.2 is hydrogen or a free or esterified carboxy group, R.sub.a and R.sub.b are hydrogen or methyl, p is zero or 1, R.sub.3 is a C.sub.1 -C.sub.2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.
摘要翻译： 2-取代的具有式I的噻唑烷化合物（I）其中X是CH 2，O或S，R是羟基或酰氧基，烷氧基，烯氧基或烷氧基，R 1是氢或式 是氢或游离或酯化的羧基，R a和R b是氢或甲基，p是0或1，R 3是C 1 -C 2烷基磺酰基，苯基或对C 1 -C 1苯基，对甲基磺酰基或酰基; 可用作粘液调节，镇咳药和抗骨质疏松剂。
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