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公开(公告)号：US20160346748A1
公开(公告)日：2016-12-01
申请号：US15171616
申请日：2016-06-02
Applicant: Raindance Technologies, Inc.
Inventor： Yevgeny Yurkovetsky , Darren R. Link , Jonathan William Larson
CPC classification number: B01F13/0076 , B01F3/0803 , B01F3/0865 , B01F5/0085 , B01F5/0471 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01L3/502784 , B01L7/525 , B01L2200/0652 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
Abstract translation: 本发明一般涉及用于形成混合液滴的方法。 在某些实施方案中，本发明的方法包括形成液滴并使液滴与流体流接触，其中流体流的一部分与液滴形成混合液滴。
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公开(公告)号：US09745617B2
公开(公告)日：2017-08-29
申请号：US15019355
申请日：2016-02-09
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren R. Link
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09127310B2
公开(公告)日：2015-09-08
申请号：US14264686
申请日：2014-04-29
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren R. Link
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
Abstract translation: 本发明一般涉及基于液滴的数字PCR和使用其进行目标核酸分析的方法。 在某些实施方案中，本发明的方法包括形成含有平均单个靶核酸的样品液滴，扩增液滴中的靶，不包含来自靶标的扩增子的液滴和来自靶标变体的扩增子，并分析靶扩增子 。
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公开(公告)号：US20180057863A1
公开(公告)日：2018-03-01
申请号：US15688250
申请日：2017-08-28
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09733168B2
公开(公告)日：2017-08-15
申请号：US15082424
申请日：2016-03-28
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Link , Mark Weary
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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Patent Agency Ranking
公开(公告)号：US20160222433A1
公开(公告)日：2016-08-04
申请号：US15019355
申请日：2016-02-09
Applicant: Raindance Technologies, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren R. Link
IPC: C12Q1/68
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20150027892A1
公开(公告)日：2015-01-29
申请号：US14511892
申请日：2014-10-10
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin J. Miller , John Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren R. Link , Mark Weary
IPC: G01N27/447
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
Abstract translation: 本发明提供了用于评估微流体通道内的微流体液滴的一个或多个预定特征或性质的方法，以及调节该通道内的一个或多个流体流速以使用反馈控制选择性地改变预定微滴特性或特性。
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公开(公告)号：US20170336306A1
公开(公告)日：2017-11-23
申请号：US15674074
申请日：2017-08-10
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin J. Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Roy Link , Mark Weary
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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公开(公告)号：US09341594B2
公开(公告)日：2016-05-17
申请号：US14511892
申请日：2014-10-10
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin J. Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren R. Link , Mark Weary
IPC: B01L3/02 , G01N27/447 , B01L3/00 , F17D3/01 , G01N21/03
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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公开(公告)号：US20160209303A1
公开(公告)日：2016-07-21
申请号：US15082424
申请日：2016-03-28
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Link , Mark Weary
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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