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14 条记录 (耗时 0.031 秒)

    Sulfonates of hydroxycoumarins
    1.
    发明授权
    Sulfonates of hydroxycoumarins 失效
    羟基香豆素磺酸盐

    公开(公告)号：US4618622A

    公开(公告)日：1986-10-21

    申请号：US552787

    申请日：1983-11-17

    申请人： Rainer Schlecker ,  Peter Schmidt ,  Peter C. Thieme ,  Dieter Lenke ,  Hans-Jurgen Teschendorf ,  Martin Traut ,  Claus D. Mueller ,  Hans P. Hofmann ,  Horst Kreiskott

    发明人： Rainer Schlecker ,  Peter Schmidt ,  Peter C. Thieme ,  Dieter Lenke ,  Hans-Jurgen Teschendorf ,  Martin Traut ,  Claus D. Mueller ,  Hans P. Hofmann ,  Horst Kreiskott

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/80 ,  A61K31/37

    CPC分类号： C07D311/80 ,  C07D311/16

    摘要： Sulfonates of hydroxycoumarins of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by --NR.sup.4 R.sup.5, --OR.sup.4 or --OC(O)R.sup.4, where R.sup.4 and R.sup.5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 are each a carboxylic acid group --OC(O)R.sup.4 or a carboxamido radical, with the proviso that R.sup.1 is not methyl when R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 together form a --(CH.sub.2).sub.n -- chain where n is 3-5, and R.sup.3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, --OR.sup.4, --NR.sup.4 R.sup.5, --CN or phenyl, or R.sup.3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group -- NR.sup.4 R.sup.5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by --OR.sup.4, --NR.sup.4 R.sup.5, --NO.sub.2, halogen, --SR.sup.4, --S(O)R.sup.4, --OS(O)R.sup.4, --SCF.sub.3, --OS(O)CF.sub.3, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NHC(O)R.sup.4, --CF.sub.3, C.sub.1 -C.sub.4 -alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R.sup.1 is methyl and R.sup.2 is hydrogen, for use as drugs.

    摘要翻译： 式I的羟基香豆素的磺酸盐其中R 1和R 2相同或不同，各自为氢，卤素或可被-NR 4 R 5，-OR 4或-OC（O）取代的1至5个碳原子的烷基 ）R 4，其中R 4和R 5相同或不同并且各自为氢或1至4个碳原子的烷基，或者R 1和R 2各自为羧酸基-OC（O）R 4或甲酰胺基，条件是R 1 当R 2为氢时，R 1和R 2一起形成 - （CH 2）n - 链，其中n为3-5，R 3为1至8个碳原子的直链或支链烷基或3个环烷基 至8个碳原子，每个可以被卤素，-OR4，-NR4R5，-CN或苯基取代，或R3是3-8个碳原子的直链或支链烯基，氨基-NR4R5或 苯基或萘基，它们各自被-OR4，-NR4R5，-NO2，卤素，-SR4，-S（O）R4，-OS（O）R4，-SCF3，-OS（O）未取代或单取代或多取代， CF 3，-CN，-C（O）R 4，-OC（O）R 4， -NHC（O）R 4，-CF 3，C 1 -C 4烷基或这些取代基的组合，其制备方法，含有这些化合物的药物和式I化合物，其中R 1是甲基，R 2是氢， 用作药物。

    Use of anipamil
    3.
    发明授权
    Use of anipamil 失效
    使用anipamil

    公开(公告)号：US4777183A

    公开(公告)日：1988-10-11

    申请号：US104216

    申请日：1987-10-05

    申请人： Dieter Lenke ,  Claus D. Mueller

    发明人： Dieter Lenke ,  Claus D. Mueller

    IPC分类号： C07D225/02 ,  A61K31/275

    CPC分类号： A61K31/275 ,  Y10S514/824

    摘要： Anipamil and its salts with physiologically tolerated acids are used for the preparation of drugs having antiarteriosclerotic properties and in the treatment of arteriosclerosis.

    摘要翻译： 阿尼巴米及其与生理耐受酸的盐用于制备具有抗动脉硬化性质的药物和用于治疗动脉硬化。

    N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds
    7.
    发明授权
    N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds 失效
    N-芳基磺酰吡咯，它们的制备和含有这些化合物的治疗剂

    公开(公告)号：US4288449A

    公开(公告)日：1981-09-08

    申请号：US154036

    申请日：1980-05-28

    申请人： Jens-Uwe Bliesener ,  Karl-Heinz Geiss ,  Dieter Lenke ,  Claus D. Mueller

    发明人： Jens-Uwe Bliesener ,  Karl-Heinz Geiss ,  Dieter Lenke ,  Claus D. Mueller

    IPC分类号： C07D207/48 ,  C07D307/68 ,  C07D333/28 ,  C07D333/38 ,  A61K31/40

    CPC分类号： C07D333/28 ,  C07D207/48 ,  C07D307/68 ,  C07D333/38

    摘要： Compounds of the formula 1 ##STR1## where R.sup.1 is a saturated, unsubstituted or substituted aliphatic radical of 1 to 8 carbon atoms, an unsaturated alkyl radical of 2 to 8 carbon atoms, a cycloalkyl radical of 3 to 7 carbon atoms in the ring or an alkyl radical of 1 to 4 carbon atoms which is substituted by phenyl or by a 5- or 6-membered aromatic heterocyclic ring containing an N, O or S atom, the phenyl ring or the heterocyclic ring itself being unsubstituted, monosubstituted or polysubstituted, andR.sup.2 is hydrogen orR.sup.1 and R.sup.2 together with the nitrogen are a 4-membered to 6-membered cycloaliphatic saturated heterocyclic ring,R.sup.3 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sup.4 and R.sup.5 are identical or different and each is hydrogen or alkyl of 1 to 5 carbon atoms,X is oxygen, sulfur or >SO- or >NH- andAr is unsubstituted, monosubstituted, disubstituted or trisubstituted phenyl,and their therapeutically useful ammonium salts, alkali metal salts or acid addition salts, which compounds and salts thereof exhibit valuable pharmacological properties, their preparation, therapeutic agents containing these products, and their use as drugs.

    摘要翻译： 式1的化合物其中R1是1至8个碳原子的饱和，未取代或取代的脂族基团，2至8个碳原子的不饱和烷基，环中3至7个碳原子的环烷基，或 由苯基或含有N，O或S原子的5-或6-元芳族杂环取代的具有1至4个碳原子的烷基，苯环或杂环本身未被取代，单取代或多取代， 并且R 2是氢或R 1和R 2与氮一起是4元至6元环脂族饱和杂环，R 3是氢或1至5个碳原子的烷基，R 4和R 5是相同或不同的，各自是氢或 1至5个碳原子的烷基，X是氧，硫或> SO-或> NH-，Ar是未取代的，单取代的，二取代的或三取代的苯基及其治疗上有用的铵盐，碱金属盐或酸加成盐， 其盐显示出有价值的药理学性质，其制备方法，含有这些产品的治疗剂及其作为药物的用途。

    Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds
    8.
    发明授权
    Aminopropanol derivatives of substituted 2-hydroxy-propiophenones, and therapeutic agents containing these compounds 失效
    取代的2-羟基丙酸的氨基酚衍生物和含有这些化合物的治疗剂

    公开(公告)号：US5118685A

    公开(公告)日：1992-06-02

    申请号：US677307

    申请日：1984-12-03

    申请人： Albrecht Franke ,  Wolfgang Spiegler ,  Hardo Siegel ,  Claus D. Mueller ,  Gerda von Philipsborn ,  Dieter Lenke ,  Josef Gries

    发明人： Albrecht Franke ,  Wolfgang Spiegler ,  Hardo Siegel ,  Claus D. Mueller ,  Gerda von Philipsborn ,  Dieter Lenke ,  Josef Gries

    IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

    CPC分类号： C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

    摘要： Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.Het is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4-yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, and antiarrhythmic agents containing these compounds.

    摘要翻译： 具有下式的氨基丙醇衍生物：其中R 1和R 2相同或不同，并且各自为氢，烷基，环烷基，烯基，炔基或羟烷基，各自不超过6个碳原子，烷氧基烷基，烷硫基烷基或二烷基氨基烷基，各自为 不超过9个碳原子，或苯基烷基或苯氧基烷基，其中烷基不超过6个碳原子，苯基是未取代的或被不多于3个碳原子的烷基或烷氧基取代，或者R1和 R2与连接它们的氮原子一起形成可被一个或两个苯基和/或羟基取代的5元至7元饱和杂环，并且可以含有氧或氮原子作为另外的杂原子 并且这样的另外的氮原子可以被1至3个碳原子的烷基或苯基取代，并且 - ＆C 1 H e是噻吩-2-基，噻吩-3-基，吡啶-2-基，吡啶-2-基， 吡啶-4-基，呋喃-2-基，1-烷基吡咯-2-基，1-烷基 1-吡咯-3-基或1-烷基吡唑-4-基，具有1至3个碳原子的烷基，以及它们与酸的生理上可耐受的加成盐，和含有这些化合物的抗心律不齐剂。