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公开(公告)号：US6150584A
公开(公告)日：2000-11-21
申请号：US724752
申请日：1996-10-02
CPC分类号： C07K16/2875 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , A01K2217/05 , A01K2217/075 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
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公开(公告)号：US20130117871A1
公开(公告)日：2013-05-09
申请号：US13561449
申请日：2012-07-30
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译： 针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。 可以进行各种随后的操作以获得本身或其类似物的抗体。
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公开(公告)号：US06657103B1
公开(公告)日：2003-12-02
申请号：US08923138
申请日：1997-09-04
IPC分类号： C12P2100
CPC分类号： C12N15/90 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2267/01 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C12N15/8509 , C12N15/87 , C12N2840/203
摘要： Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译： 具有针对特异性抗原的完全人可变区的抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。 可以进行各种随后的操作以获得本身或其类似物的抗体。
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公开(公告)号：US6075181A
公开(公告)日：2000-06-13
申请号：US486857
申请日：1995-06-07
CPC分类号： C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , A01K2217/05 , A01K2217/075 , C07K2317/21 , C07K2317/24
摘要： Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
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公开(公告)号：US20090149637A1
公开(公告)日：2009-06-11
申请号：US11891292
申请日：2007-08-08
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译： 针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。 可以进行各种随后的操作以获得本身或其类似物的抗体。
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公开(公告)号：US6162963A
公开(公告)日：2000-12-19
申请号：US462513
申请日：1995-06-05
IPC分类号： A01K67/027 , A61K38/00 , C07K16/00 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/46 , C12N15/85 , C12N15/87 , C12N15/90 , A61K48/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C12N15/87 , C12N15/90
摘要： The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.
摘要翻译： 本发明提供非人哺乳动物宿主，其特征在于灭活的内源性Ig基因座和功能性人Ig基因座，用于响应于免疫原以产生人抗体或其类似物。 宿主通过与育种相结合的胚胎细胞的多种遗传修饰产生。 采用不同的策略来随机或类似的宿主基因座重组人基因座。 提供嵌合和转基因哺乳动物，特别是小鼠，其具有稳定整合的大的异种DNA片段。 通过与包括异种DNA片段的酵母人造染色体（YAC）和选择性标记如HPRT和胚胎干细胞的酵母原生质球融合引入片段。
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公开(公告)号：US20100010202A1
公开(公告)日：2010-01-14
申请号：US11894775
申请日：2007-08-20
IPC分类号： C07K16/24
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2267/01 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C12N15/87 , C12N15/90 , C12N2800/206 , C12N2840/203
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译： 针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。 可以进行各种随后的操作以获得本身或其类似物的抗体。
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公开(公告)号：US06713610B1
公开(公告)日：2004-03-30
申请号：US09614092
申请日：2000-07-11
IPC分类号： A61K39395
CPC分类号： C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2267/01 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C12N15/87 , C12N15/90 , C12N2800/206 , C12N2840/203
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译： 针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已经被禁用。 可以进行各种随后的操作以获得本身或其类似物的抗体。
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公开(公告)号：US06673986B1
公开(公告)日：2004-01-06
申请号：US08031801
申请日：1993-03-15
IPC分类号： A01K67033
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/03 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C12N15/87 , C12N15/90
摘要： The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.
摘要翻译： 本发明提供非人哺乳动物宿主，其特征在于灭活的内源性Ig基因座和功能性人Ig基因座，用于响应于免疫原以产生人抗体或其类似物。 宿主通过与育种相结合的胚胎细胞的多种遗传修饰产生。 采用不同的策略来随机或类似的宿主基因座重组人基因座。 提供嵌合和转基因哺乳动物，特别是小鼠，其具有稳定整合的大的异种DNA片段。 通过与包括异种DNA片段的酵母人造染色体（YAC）和选择性标记如HPRT和胚胎干细胞的酵母原生质球融合引入片段。
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公开(公告)号：US06114598A
公开(公告)日：2000-09-05
申请号：US464582
申请日：1995-06-05
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61K39/395 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/46 , C07K19/00 , C12N20060101 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/00 , C12P21/06 , C12P21/08 , C12R1/91 , A61K48/00 , C12N15/79
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , C07K16/00 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K38/00 , C07K2317/21 , C07K2317/24
摘要： The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.
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