公开(公告)号：US06692940B2

公开(公告)日：2004-02-17

申请号：US10281673

申请日：2002-10-28

申请人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

发明人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

IPC分类号： C12P2102

CPC分类号： C12N9/2428 ,  C07K14/37 ,  C12N15/80

摘要： The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO. 1, nucleotides 1 to 938 of SEQ ID NO. 2, and nucleotides 1 to 3060 of SEQ ID NO. 3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.

摘要翻译： 本发明涉及生产多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一核酸序列，其可操作地连接到 第二核酸序列，其包含核酸序列外源的启动子，其中所述启动子包含选自SEQ ID NO：1的核苷酸1至3949的序列。 1，SEQ ID NO：1的核苷酸1至938。 2和SEQ ID NO：1的核苷酸1至3060。 3及其子序列; 及其突变体，杂种和串联启动子; 和（b）从培养基中分离多肽。 本发明还涉及分离的启动子序列和构建体，载体和真菌宿主细胞，其包含可操作地连接到编码多肽的核酸序列的启动子序列。

公开(公告)号：US06361973B1

公开(公告)日：2002-03-26

申请号：US09534407

申请日：2000-03-22

申请人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

发明人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

IPC分类号： C12P2102

CPC分类号： C12N9/2428 ,  C07K14/37 ,  C12N15/80

摘要： The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO:1, nucleotides 1 to 938 of SEQ ID NO:2, and nucleotides 1 to 3060 of SEQ ID NO:3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.

摘要翻译： 本发明涉及生产多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一核酸序列，其可操作地连接到 第二核酸序列，其包含核酸序列外源的启动子，其中所述启动子包含选自SEQ ID NO：1的核苷酸1至3949，SEQ ID NO：2的核苷酸1至938和核苷酸的核苷酸 SEQ ID NO：3的1〜3060及其子序列; 及其突变体，杂种和串联启动子; 和（b）从培养基中分离多肽。 本发明还涉及分离的启动子序列和构建体，载体和真菌宿主细胞，其包含可操作地连接到编码多肽的核酸序列的启动子序列。

公开(公告)号：US06518044B1

公开(公告)日：2003-02-11

申请号：US09999201

申请日：2001-10-30

申请人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

发明人： Randy M. Berka ,  Michael W. Rey ,  Kimberly Brown ,  Stephen H. Brown

IPC分类号： C12P2102

CPC分类号： C12N9/2428 ,  C07K14/37 ,  C12N15/80

摘要： The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first nucleic acid sequence encoding the polypeptide operably linked to a second nucleic acid sequence comprising a promoter foreign to the nucleic acid sequence, wherein the promoter comprises a sequence selected from the group consisting of nucleotides 1 to 3949 of SEQ ID NO:1, nucleotides 1 to 938 of SEQ ID NO:2, and nucleotides 1 to 3060 of SEQ ID NO:3, and a subsequence thereof; and mutant, hybrid, and tandem promoters thereof; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to the isolated promoter sequences and to constructs, vectors, and fungal host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides.

公开(公告)号：US09057025B2

公开(公告)日：2015-06-16

申请号：US13186039

申请日：2011-07-19

申请人： Stephen H. Brown

发明人： Stephen H. Brown

IPC分类号： C10G25/03 ,  B01J29/06 ,  B01J29/70

CPC分类号： C10G25/03 ,  C10G2300/1096 ,  C10G2300/201 ,  C10G2300/4081 ,  C10G2400/30

摘要： The invention is a process for removing impurities from an aromatics stream and apparatus for the practice thereof, whereby trace olefins and dienes are removed from aromatic plant feedstocks using a reactor design that enables the product to be backmixed with the feedstock and that enables a feed/effluent heat exchanger.

摘要翻译： 本发明是用于从芳族化合物流中除去杂质的方法及其实践的装置，其中使用能使产物与原料反混的反应器设计从芳族植物原料中除去痕量烯烃和二烯， 流出热交换器。

公开(公告)号：US08696888B2

公开(公告)日：2014-04-15

申请号：US11581882

申请日：2006-10-17

申请人： Paul F. Keusenkothen ,  Megan L. Renstrom ,  Julian A. Wolfenbarger ,  Stephen H. Brown ,  John S. Buchanan

发明人： Paul F. Keusenkothen ,  Megan L. Renstrom ,  Julian A. Wolfenbarger ,  Stephen H. Brown ,  John S. Buchanan

IPC分类号： C10G9/36

CPC分类号： B01D3/009 ,  C10G9/007 ,  C10G9/14 ,  C10G9/36 ,  C10G45/00 ,  C10G45/44 ,  C10G69/00 ,  C10G69/06 ,  C10G2300/107 ,  C10G2400/20 ,  C10G2400/30

摘要： The invention concerns integration of hydroprocessing and steam cracking. A feed comprising crude or resid-containing fraction thereof is severely hydrotreated and passed to a steam cracker to obtain an olefins product.

摘要翻译： 本发明涉及加氢处理和蒸汽裂化的整合。 包含粗制或残留物的级分的进料被严重加氢处理并通入蒸汽裂化器以获得烯烃产物。

公开(公告)号：US20140061094A1

公开(公告)日：2014-03-06

申请号：US13601113

申请日：2012-08-31

申请人： Teng Xu ,  Paul M. Edwards ,  Stephen H. Brown ,  Frank C. Wang ,  S. Mark Davis

发明人： Teng Xu ,  Paul M. Edwards ,  Stephen H. Brown ,  Frank C. Wang ,  S. Mark Davis

IPC分类号： C10C1/20 ,  C10C1/00 ,  C10L1/02

CPC分类号： C10L1/04 ,  C10G9/36 ,  C10G49/00 ,  C10G69/06 ,  C10G2300/301 ,  C10G2300/302 ,  C10L2200/0407

摘要： The invention relates to a hydroprocessed product that can be produced by hydroprocessing tar, such as a tar obtained from hydrocarbon pyrolysis. The invention also relates to methods for producing such a hydroprocessed product, and the use of such a product, e.g., as a fuel oil blending component.

摘要翻译： 本发明涉及一种加氢处理产物，其可通过加氢处理焦油（例如由烃热解得到的焦油）来生产。 本发明还涉及生产这种加氢处理产品的方法，以及这种产品的使用，例如作为燃料油混合组分。

公开(公告)号：US20130156656A1

公开(公告)日：2013-06-20

申请号：US13768640

申请日：2013-02-15

申请人： S. Mark Davis ,  Richard C. Stell ,  Jiunn-Shyan Liou ,  Stephen H. Brown ,  Paul F. Keusenkothen ,  Arthur R. Dinicolantonio ,  John J. Waldrop

发明人： S. Mark Davis ,  Richard C. Stell ,  Jiunn-Shyan Liou ,  Stephen H. Brown ,  Paul F. Keusenkothen ,  Arthur R. Dinicolantonio ,  John J. Waldrop

IPC分类号： B01J10/00

CPC分类号： B01J10/005 ,  C10B55/00 ,  C10B55/10 ,  C10G9/005 ,  C10G9/007 ,  C10G9/36 ,  C10G51/023 ,  C10G2300/1077 ,  C10G2300/301 ,  C10G2300/4006 ,  C10G2300/807 ,  C10G2400/20 ,  C10G2400/30

摘要： This invention relates to a process and system for cracking hydrocarbon feedstock containing vacuum resid comprising: (a) subjecting a vacuum resid to a first thermal conversion in a thermal conversion reactor (such as delayed coker, fluid coker, Flexicoker™, visbreaker and catalytic hydrovisbreaker) where at least 30 wt % of the vacuum resid is converted to material boiling below 1050° F. (566° C.); (b) introducing said thermally converted resid to a vapor/liquid separator, said separator being integrated into a steam cracking furnace, to form a vapor phase and liquid phase; (c) passing said vapor phase to the radiant furnace in said steam cracking furnace; and (d) recovering at least 30 wt % olefins from the material exiting the radiant furnace (based upon the weight of the total hydrocarbon material exiting the radiant furnace).

摘要翻译： 本发明涉及一种用于裂化含有真空渣油的烃原料的方法和系统，该方法和系统包括：（a）在热转化反应器（例如延迟焦化器，流体焦化器，Flexicoker TM，减粘裂化器和 催化脱硫剂），其中至少30重量％的真空渣油转化成沸点低于1050°F（566℃）的材料; （b）将所述热转化残渣引入蒸汽/液体分离器，所述分离器整合成蒸汽裂解炉，形成气相和液相; （c）将所述气相通过所述蒸汽裂解炉中的辐射炉; 和（d）从离开辐射炉的材料（基于离开辐射炉的总烃材料的重量）回收至少30重量％的烯烃。

公开(公告)号：US08177965B2

公开(公告)日：2012-05-15

申请号：US11980157

申请日：2007-10-30

申请人： Daniel P. Leta ,  Eric B. Sirota ,  Edward W. Corcoran ,  Anjaneya S. Kovvali ,  Stephen H. Brown ,  Stephen M. Cundy

发明人： Daniel P. Leta ,  Eric B. Sirota ,  Edward W. Corcoran ,  Anjaneya S. Kovvali ,  Stephen H. Brown ,  Stephen M. Cundy

IPC分类号： C07C7/144

CPC分类号： C10G31/11 ,  C10G2300/1033 ,  C10G2300/107

摘要： This invention relates to an ultrafiltration process for separating a heavy hydrocarbon stream to produce an enriched saturates content stream(s) utilizing an ultrafiltration separations process. The enriched saturates content streams can then be further processed in refinery and petrochemical processes that will benefit from the higher content of saturated hydrocarbons produced from this separations process. The invention may be utilized to separate heavy hydrocarbon feedstreams, such as whole crudes, topped crudes, synthetic crude blends, shale oils, oils derived from bitumen, oils derived from tar sands, atmospheric resids, vacuum resids, or other heavy hydrocarbon streams into enriched saturates content product streams. The invention provides an economical method for separating heavy hydrocarbon stream components by molecular species instead of molecular boiling points.

摘要翻译： 本发明涉及一种用于分离重质烃流以利用超滤分离方法产生富集的饱和物含量物流的超滤方法。 然后可以在炼油和石油化学方法中进一步处理富集的饱和物质流，这将从该分离过程产生的较高含量的饱和烃受益。 本发明可以用于分离重烃进料流，例如整个原油，顶部原油，合成粗混合物，页岩油，来自沥青的油，源自焦油砂的油，常压渣油，减压渣油或其它重质烃流进入富集 饱和内容产品流。 本发明提供了一种经分子物质代替分子沸点分离重质烃流成分的经济方法。

公开(公告)号：US08048295B2

公开(公告)日：2011-11-01

申请号：US11633971

申请日：2006-12-05

申请人： Stephen H. Brown ,  Jose G. Santiesteban ,  Bryson J. Sundberg ,  Terry E. Helton ,  Daria N. Lissy ,  Jean W. Beeckman ,  Arthur P. Werner

发明人： Stephen H. Brown ,  Jose G. Santiesteban ,  Bryson J. Sundberg ,  Terry E. Helton ,  Daria N. Lissy ,  Jean W. Beeckman ,  Arthur P. Werner

IPC分类号： C10G25/03

CPC分类号： C10G29/02 ,  B01J29/7007 ,  B01J29/7038 ,  B01J35/023 ,  B01J35/026 ,  C10G2300/1096 ,  C10G2300/4018

摘要： A process for reducing the Bromine Index of a hydrocarbon feed containing bromine-reactive contaminants that has improved cycle length and utilizes a crystalline molecular sieve catalyst. The process is carried out by contacting the hydrocarbon feed under conversion conditions with a catalyst shaped in the form of an elongated aggregate comprising a crystalline molecular sieve having a MWW or *BEA framework type. The shortest cross-sectional dimension of the elongated aggregate is less about 1/10 inch (2.54 millimeters).

摘要翻译： 一种降低含溴反应性污染物的烃进料的溴指数的方法，其具有改善的循环长度并且使用结晶分子筛催化剂。 该方法通过在转化条件下使烃进料与包含具有MWW或* BEA骨架类型的结晶分子筛的细长骨料形式的催化剂接触来进行。 细长骨料的最短横截面尺寸较小约为1/10英寸（2.54毫米）。

公开(公告)号：US20110054128A1

公开(公告)日：2011-03-03

申请号：US12837546

申请日：2010-07-16

申请人： Guang CAO ,  Thomas H. Colle ,  Luc R.M. Martens ,  Stephen H. Brown ,  Teng Xu

发明人： Guang CAO ,  Thomas H. Colle ,  Luc R.M. Martens ,  Stephen H. Brown ,  Teng Xu

IPC分类号： C08F2/00 ,  C07C1/00

CPC分类号： C07C1/20 ,  C08F10/00 ,  C08F210/16 ,  C08F2400/02 ,  Y02P30/42 ,  C07C11/06 ,  C07C11/04 ,  C08F2/00 ,  C08F210/06

摘要： Disclosed herein is a method of controlling production of olefins in an oxygenates-to-olefins reaction by combining in a reactor methanol and a molecular sieve, a AlPO or SAPO in certain embodiments, under conditions to produce at least ethylene and propylene having a first ethylene/propylene ratio; adding to the reactor a first amount of a C1 to C5 aldehyde; and withdrawing from the reactor a first amount of ethylene and propylene having a second ethylene/propylene ratio, wherein the second ethylene/propylene ratio is greater than the first ethylene/propylene ratio. The aldehyde is added at the same time, or co-feed, with the methanol under the same reaction conditions.

摘要翻译： 本文公开了一种通过在反应器甲醇和分子筛，AlPO或SAPO中在某些实施方案中，在至少产生具有第一个乙烯的乙烯和丙烯的条件下混合来控制含氧化合物至烯烃反应中的烯烃的生产的方法 /丙烯比; 向反应器中加入第一量的C1至C5醛; 并从所述反应器中排出具有第二乙烯/丙烯比率的第一量乙烯和丙烯，其中所述第二乙烯/丙烯比率大于所述第一乙烯/丙烯比。 在相同的反应条件下，与甲醇同时加入醛或共同进料。