公开(公告)号：US20100187133A1

公开(公告)日：2010-07-29

申请号：US12362071

申请日：2009-01-29

申请人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

发明人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

IPC分类号： G01N27/26

CPC分类号： C12Q1/6825 ,  Y10T436/143333 ,  C12Q2525/113

摘要： Surface hybridization, a reaction in which nucleic acid molecules in solution react with nucleic acid partners immobilized on a surface, is widely practiced in life science research. In these applications the immobilized partner, or “probe”, is typically single-stranded DNA. Because DNA is strongly charged, high salt conditions are required to enable binding between analyte nucleic acids (“targets”) in solution and the DNA probes. High salt, however, compromises prospects for label-free monitoring or control of the hybridization reaction through surface electric fields, as well as stabilizes secondary structure in target species that can interfere with probe-target recognition. In this work, initial steps toward addressing these challenges are taken by introducing Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports can be fabricated with methods similar to those employed with DNA, and are shown to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Interestingly, positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm−2 range.

摘要翻译： 表面杂交，其中溶液中的核酸分子与固定在表面上的核酸配偶体反应的反应在生命科学研究中广泛应用。 在这些应用中，固定化的配偶体或“探针”通常是单链DNA。 由于DNA是强电荷的，因此需要高盐条件才能使溶液中的分析物核酸（“靶”）与DNA探针结合。 然而，高盐不利于通过表面电场进行无标记监测或控制杂交反应的前景，以及稳定可能干扰探针 - 目标识别的靶物种中的二级结构。 在这项工作中，通过引入Morpholinos（一类不带电荷的DNA类似物）进行表面杂交应用来采取解决这些挑战的最初步骤。 可以用与DNA一起使用的方法类似的方法制备金载体上的Morpholino探针的单层，并且显示与靶链有效地并且序列特异性地杂交。 用电化学方法分析杂交诱导的界面电荷组织变化，并比较Morpholino和DNA探针单层。 通过与数值泊松 - 玻尔兹曼计算进行比较，可以确定和解释连接表面杂交态与界面电容的分子机制。 有趣的是，取决于由施加电位控制的移动离子的表面种群，杂交的阳性和负电容反应（对比反转）是可能的。 表面电容与目标覆盖（目标/面积）的定量比较显示近似线性关系，并显示pg mm-2范围内的灵敏度（定量限度）。

公开(公告)号：US08263411B2

公开(公告)日：2012-09-11

申请号：US12362071

申请日：2009-01-29

申请人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

发明人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

IPC分类号： G01N33/50

CPC分类号： C12Q1/6825 ,  Y10T436/143333 ,  C12Q2525/113

摘要： A method to monitor the progress of hybridization between nucleic acid strands in solution and Morpholino strands immobilized on a solid support such as a working electrode in-situ, in real-time, and using label-free electrochemical measurements sensitive to hybridization-induced changes in the near-surface dielectric constant and charge organization.

摘要翻译： 监测溶液中核酸链之间杂交进程的方法和实时固定在固体支持物如工作电极上的Morpholino链，并使用对杂交诱导的变化敏感的无标记电化学测量 近表面介电常数和电荷组织。

公开(公告)号：US20120211375A1

公开(公告)日：2012-08-23

申请号：US13423228

申请日：2012-03-18

申请人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

发明人： Rastislav Levicky ,  Napoleon Tercero ,  Kang Wang ,  Ping Gong ,  Kenneth Shepard

IPC分类号： G01N33/50 ,  G01N27/26

CPC分类号： C12Q1/6825 ,  Y10T436/143333 ,  C12Q2525/113

摘要： Use of Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated with methods similar to those employed with DNA, and are used to hybridize efficiently and sequence-specifically with target strands. Hybridization-induced changes in the interfacial charge organization are analyzed with electrochemical methods and compared for Morpholino and DNA probe monolayers. Molecular mechanisms connecting surface hybridization state to the interfacial capacitance are identified and interpreted through comparison to numerical Poisson-Boltzmann calculations. Positive as well as negative capacitive responses (contrast inversion) to hybridization are possible, depending on surface populations of mobile ions as controlled by the applied potential. Quantitative comparison of surface capacitance with target coverage (targets/area) reveals a near-linear relationship, and demonstrates sensitivities (limits of quantification) in the pg mm−2 range.

摘要翻译： 使用Morpholinos，一类不带电荷的DNA类似物，用于表面杂交应用。 使用类似于DNA使用的方法制备金支持物上的Morpholino探针的单层，并且用于与靶链有效地和序列特异性地杂交。 用电化学方法分析杂交诱导的界面电荷组织变化，并比较Morpholino和DNA探针单层。 通过与数值泊松 - 玻尔兹曼计算进行比较，可以确定和解释连接表面杂交态与界面电容的分子机制。 取决于由施加电位控制的移动离子的表面种群，对于杂交，阳性以及负电容反应（对比反转）是可能的。 表面电容与目标覆盖（目标/面积）的定量比较显示近似线性关系，并显示pg mm-2范围内的灵敏度（定量限度）。

公开(公告)号：US08793113B2

公开(公告)日：2014-07-29

申请号：US12966716

申请日：2010-12-13

申请人： Philippe Marza ,  Arnaud Etchecopar ,  Kang Wang ,  Mi Zhou ,  Shiduo Yang

发明人： Philippe Marza ,  Arnaud Etchecopar ,  Kang Wang ,  Mi Zhou ,  Shiduo Yang

IPC分类号： G06G7/48

CPC分类号： G06T17/05 ,  G01V1/301 ,  G01V1/50 ,  G01V2210/643 ,  G01V2210/665

摘要： A method for structure modeling of a formation penetrated by multiple wells includes obtaining borehole dips from borehole measurements; filtering the borehole dips based on a dip sequence analysis; computing structural dips based on the filtered dips; computing structural delineation by using the structural dips; projecting the structural dips to horizon point sets based on the structural delineation; and generating stratigraphic surfaces by mapping the projected horizon point sets. A system for structure modeling of a formation penetrated by multiple wells includes a processor and a memory that store a program having instructions for: obtaining borehole dips from borehole measurements; filtering the borehole dips based on a dip sequence analysis; computing structural dips based on the filtered dips; computing structural delineation by using the structural dips; projecting the structural dips to horizon point sets based on the structural delineation; and generating stratigraphic surfaces by mapping the projected horizon point sets.

摘要翻译： 由多个井渗透的地层的结构建模方法包括从钻孔测量获得钻孔倾角; 基于dip序列分析过滤井眼凹陷; 基于过滤的倾倒计算结构倾斜; 通过结构性倾斜计算结构划分; 根据结构性划分将结构倾斜预测为水平点集; 并通过映射投影的水平点集来产生地层表面。 用于由多个井渗透的地层的结构建模的系统包括处理器和存储器，其存储具有以下指令的程序的存储器：从井眼测量获得钻孔倾斜; 基于dip序列分析过滤井眼凹陷; 基于过滤的倾倒计算结构倾斜; 通过结构性倾斜计算结构划分; 根据结构性划分将结构倾斜预测为水平点集; 并通过映射投影的水平点集来产生地层表面。

公开(公告)号：US07756724B2

公开(公告)日：2010-07-13

申请号：US10301486

申请日：2002-11-21

申请人： Adrian Gropper ,  Sean Doyle ,  Terry Rosenbaum ,  Hamid Tabatabaie ,  Kang Wang

发明人： Adrian Gropper ,  Sean Doyle ,  Terry Rosenbaum ,  Hamid Tabatabaie ,  Kang Wang

IPC分类号： G06Q10/00 ,  G06Q50/00 ,  A61B5/00 ,  G06F19/00 ,  G06Q40/00

CPC分类号： G06Q10/02 ,  G06F19/00 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G16H40/20

摘要： A system and methods for organizing, manipulating, and displaying worklists of patient studies for access by medical personnel is provided. The patient studies may include medical images and data relating to medical images. In some embodiments, the worklists are easily customizable, to permit a wide range of tasks to be handled in the worklist system. Updated worklist information may be pushed to the appropriate workstations or users in nearly real-time, as updates become available, reducing errors that may be caused by outdated information in worklists. In some embodiments, worklists contain overlapping information, which permits numerous users to see the information, even if it is not immediately relevant to their tasks. This increased scrutiny may help to reduce errors.

摘要翻译： 提供了一种用于组织，操纵和显示患者研究工作列表以供医务人员进入的系统和方法。 患者研究可以包括与医学图像相关的医学图像和数据。 在一些实施例中，工作列表易于定制，以允许在工作列表系统中处理大范围的任务。 更新的工作列表信息可能几乎实时地推送到相应的工作站或用户，因为更新可用，从而减少可能由工作列表中的过时信息引起的错误。 在一些实施例中，工作列表包含重叠的信息，其允许许多用户查看信息，即使它们不直接与其任务相关。 这种增加的审查可能有助于减少错误。

公开(公告)号：US20060231754A1

公开(公告)日：2006-10-19

申请号：US11279540

申请日：2006-04-12

申请人： Kang Wang ,  Fei Liu

发明人： Kang Wang ,  Fei Liu

IPC分类号： G21K7/00

CPC分类号： G01Q60/48 ,  G01Q70/12 ,  Y10S977/84 ,  Y10S977/849 ,  Y10S977/86 ,  Y10S977/875 ,  Y10S977/876

摘要： A microscope device includes a probe having a dielectric material with a first side and a second side. First and second electrodes are disposed on the first side of the dielectric material. A nanotube connects the first and second electrodes. A gate electrode is disposed on the second side (e.g., backside) of the dielectric material. The device includes a stage adapted for holding a sample. The stage and probe are moveable with respect to one another such that the sample can be brought in close proximity to the nanotube. The device further includes current measurement circuitry for measuring current (e.g., Random Telegraph Signals) passing through the nanotube. The microscope device is able to identify and characterize single defects on the molecular or atomic scale. The probe device may be combined with spin resonance and/or optical systems such that the detection/mapping/manipulate of single spin and single photon could be achieved.

摘要翻译： 显微镜装置包括具有第一侧和第二侧的电介质材料的探针。 第一和第二电极设置在电介质材料的第一侧上。 纳米管连接第一和第二电极。 栅电极设置在电介质材料的第二侧（例如背面）上。 该装置包括适于容纳样品的台。 阶段和探针可以相对于彼此移动，使得样品可以靠近纳米管。 该装置还包括用于测量通过纳米管的电流（例如，随机电报信号）的电流测量电路。 显微镜装置能够识别和表征分子或原子尺度上的单一缺陷。 探针装置可以与自旋共振和/或光学系统组合，使得可以实现单个旋转和单个光子的检测/映射/操纵。

公开(公告)号：US20140355572A1

公开(公告)日：2014-12-04

申请号：US14128353

申请日：2011-07-25

申请人： Aamod Dinkar Khandekar ,  Srikanth Gummadi ,  Kang Wang ,  Minkui Liu

发明人： Aamod Dinkar Khandekar ,  Srikanth Gummadi ,  Kang Wang ,  Minkui Liu

IPC分类号： H04W74/08 ,  H04W52/52

CPC分类号： H04W74/0891 ,  H04W52/52

摘要： A method and apparatus in wireless communications is provided. The method may include measuring received powers levels for a first window of samples, and computing a gain value based on the measured received powers levels. The method may also include determining an offset duration such that the first window of samples and a second window of samples both are included within a downlink region that has downlink power within a threshold level. The method may additionally include applying the gain value to the second window of samples, and the second window of samples may occur after the offset duration.

摘要翻译： 提供了一种无线通信中的方法和装置。 该方法可以包括测量第一采样窗口的接收功率电平，以及基于测量的接收功率电平来计算增益值。 该方法还可以包括确定偏移持续时间，使得第一采样窗口和第二采样窗口都包括在具有阈值电平内的下行链路功率的下行链路区域内。 该方法可以另外包括将增益值应用于第二采样窗口，并且第二采样窗口可以在偏移持续时间之后发生。

公开(公告)号：US20140025393A1

公开(公告)日：2014-01-23

申请号：US13942925

申请日：2013-07-16

申请人： Kang Wang ,  Wilson S. Wong ,  Dmitry Berdichevsky

发明人： Kang Wang ,  Wilson S. Wong ,  Dmitry Berdichevsky

IPC分类号： G06F19/00

CPC分类号： G16H50/70 ,  G16H50/20

摘要： A clinical decision support system comprises a memory device having a plurality of routines stored therein, a processor configured to execute the plurality of routines stored in the memory device, the plurality of routines comprising a routine configured to receive primary clinical information from a user associated with a patient, a routine configured to derive expanded clinical information from the user-provided primary clinical information, a routine configured to identify relevant rules from a data store based on the user-provided clinical information and the expanded clinical information, a routine configured to compute a diagnostic relevancy score for each of the identified relevant rules; a routine configured to assign by the processing device the computed diagnostic relevancy score to each identified relevant rule, and a routine configured to display each identified rule in ranked order based on the rule's assigned diagnostic relevancy score.

摘要翻译： 临床决策支持系统包括具有存储在其中的多个例程的存储器设备，配置为执行存储在存储器设备中的多个例程的处理器，所述多个例程包括被配置为从与用户相关联的用户接收主要临床信息的例程 患者，被配置为从所述用户提供的主要临床信息中导出扩展的临床信息的例程，被配置为基于所述用户提供的临床信息和所述扩展的临床信息从数据存储区识别相关规则的例程，所述例程被配置为计算 每个确定的相关规则的诊断相关性得分; 配置为由处理装置将计算出的诊断相关性分数分配给每个识别的相关规则的例程，以及被配置为基于规则的分配的诊断相关性得分以排序的顺序显示每个识别的规则的例程。

公开(公告)号：US20110241677A1

公开(公告)日：2011-10-06

申请号：US13051952

申请日：2011-03-18

申请人： Reed Frederick Busse ,  James Holmes ,  Philip James Beatty ,  Kang Wang ,  Frank Korosec

发明人： Reed Frederick Busse ,  James Holmes ,  Philip James Beatty ,  Kang Wang ,  Frank Korosec

IPC分类号： G01R33/44

CPC分类号： G01R33/56308 ,  G01R33/4818 ,  G01R33/5611

摘要： The present disclosure is intended to describe embodiments for improving image data acquisition and processing in accelerated dynamic magnetic resonance imaging sequences. One embodiment is described where a method includes an acquisition sequence configured to acquire an undersampled set of magnetic resonance data. The undersampled set of magnetic resonance data has a pseudo-random sampling pattern within a data space acquired at a first time, the pseudo-random sampling pattern being influenced by other pseudo-random sampling patterns within the data space arising from the acquisition of additional undersampled sets of magnetic resonance data at respective times. In some embodiments, the pseudo-random sampling patterns of the undersampled sets of magnetic resonance data interleave to yield a desired sampling pattern.

摘要翻译： 本公开旨在描述用于改进加速动态磁共振成像序列中的图像数据采集和处理的实施例。 描述一个实施例，其中方法包括被配置为获取欠采样的磁共振数据集合的获取序列。 欠采样的磁共振数据集合在第一时间获取的数据空间内具有伪随机采样模式，伪随机采样模式受数据空间内的其他伪随机采样模式的影响，该模式由获得额外的欠采样 各磁共振数据组。 在一些实施例中，欠采样的磁共振数据组的伪随​​机采样模式交织以产生期望的采样模式。

公开(公告)号：US20090197632A1

公开(公告)日：2009-08-06

申请号：US12362435

申请日：2009-01-29

申请人： Donna Ghosh ,  Qingxin Chen ,  Christopher Gerard Lott ,  Jun Hu ,  Rashid Ahmed Akbar Attar ,  Kang Wang

发明人： Donna Ghosh ,  Qingxin Chen ,  Christopher Gerard Lott ,  Jun Hu ,  Rashid Ahmed Akbar Attar ,  Kang Wang

IPC分类号： H04B7/00

CPC分类号： H04W52/24 ,  H04W52/34

摘要： Allocating transmit power among two or more carriers assigned to a wireless communication device is disclosed. In one aspect, a method of allocating transmit power includes determining a total amount of data transmit power available at the wireless communication device for data transmission over the carriers. An efficiency metric is determined for each carrier based on the carrier's transmission characteristics and a portion of the total data transmit power is allocated to each carrier based on each carrier's efficiency metric.

摘要翻译： 公开了分配给无线通信设备的两个或多个载波之间的分配发射功率。 在一个方面，一种分配发射功率的方法包括确定在无线通信设备处可用的数据传输功率的总量，用于通过载波进行数据传输。 基于载波的传输特性为每个载波确定效率度量，并且基于每个载波的效率度量将总数据发射功率的一部分分配给每个载波。