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    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
    3.
    发明授权
    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same 失效
    可用作抗高胆固醇血症药的米维酸衍生物及其制备方法

    公开(公告)号：US5166364A

    公开(公告)日：1992-11-24

    申请号：US765806

    申请日：1991-09-26

    申请人： Jeffrey O. Saunders ,  Eric M. Gordon

    发明人： Jeffrey O. Saunders ,  Eric M. Gordon

    IPC分类号： C07C59/11 ,  C07D309/30 ,  C07F7/18

    CPC分类号： C07F7/1856 ,  C07C59/11 ,  C07D309/30

    摘要： Mevinic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy- 2-methyl)-substituted-decahydronaphthalene esters and have the structure ##STR1## wherein Z is ##STR2## wherein R is alkali metal such as Na, or H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents.In addition, a method for preparing the above-mevinic acid derivatives is also provided.

    摘要翻译： 提供了6-羟基-8-（2,2-二甲基-1-氧丁氧基-2-甲基） - 取代十氢萘酯的维甲酸衍生物，其结构为：其中R为碱 金属如Na或H或低级烷基，并且是HMG CoA还原酶抑制剂，因此可用作抗高胆固醇血症药物和治疗动脉粥样硬化，并且还可用作抗真菌剂。 此外，还提供了制备上述维甲酸衍生物的方法。

    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
    4.
    发明授权
    Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same 失效
    可用作抗高胆固醇血症药的米维酸衍生物及其制备方法

    公开(公告)号：US5099035A

    公开(公告)日：1992-03-24

    申请号：US662597

    申请日：1991-03-01

    申请人： Jeffrey O. Saunders ,  Eric M. Gordon

    发明人： Jeffrey O. Saunders ,  Eric M. Gordon

    IPC分类号： C07C59/11 ,  C07D309/30 ,  C07F7/18

    CPC分类号： C07D309/30 ,  C07C59/11 ,  C07F7/1856

    摘要： Mevinic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxybutoxy-2-methyl)-substituted-decahydronaphthalene esters and have the structure ##STR1## wherein Z is ##STR2## wherein R is alkali metal such as Na, or H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents.In addition, a method for preparing the above-mevinic acid derivatives is also provided.

    摘要翻译： 提供了6-羟基-8-（2,2-二甲基-1-氧丁氧基-2-甲基） - 取代十氢邻苯二甲酸酯的维甲酸衍生物，并且具有其中Z为的结构，其中R为 碱金属如Na或H或低级烷基，并且是HMG CoA还原酶抑制剂，因此可用作抗高胆固醇血症药物和治疗动脉粥样硬化，并且还可用作抗真菌剂。 此外，还提供了制备上述维甲酸衍生物的方法。

    Mevinic acid derivatives
    5.
    发明授权
    Mevinic acid derivatives 失效
    乙酸衍生物

    公开(公告)号：US5001148A

    公开(公告)日：1991-03-19

    申请号：US362899

    申请日：1989-06-07

    申请人： Jeffrey O. Saunders ,  Eric M. Gordon

    发明人： Jeffrey O. Saunders ,  Eric M. Gordon

    IPC分类号： A61K31/215 ,  A01N37/18 ,  A61K31/235 ,  A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C235/04 ,  C07C235/06 ,  C07C235/08 ,  C07C235/16 ,  C07C239/06 ,  C07D295/18 ,  C07D295/185 ,  C07D309/30 ,  C07F7/18

    CPC分类号： C07D295/185 ,  C07C235/06 ,  C07C235/08 ,  C07C235/16 ,  C07D309/30 ,  C07F7/1856 ,  C07C2102/28

    摘要： Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from:(1) alkyl,(2) substituted alkyl in which one or more substituents are selected from(a) halogen,(b) hydroxyl,(c) alkoxy,(d) alkoxycarbonyl,(e) acyloxy,(f) cycloalkyl,(g) phenyl,(h) substituted phenyl in which one or more substituents are X or Y,(i) alkyl-S(O).sub.n,(j) cycloalkyl-S(O).sub.n,(k) phenyl-S(O).sub.n,(l) substituted phenyl-S(O).sub.n in which one or more substituents are X or Y, and(m) oxo,(3) alkoxy,(4) alkenyl,(5) cycloalkyl,(6) substituted cycloalkyl in which one or more substituents are selected from(a) alkyl,(b) substituted alkyl in which one or more substituents are selected from(i) halogen,(ii) hydroxy,(iii) alkoxy,(iv) alkoxycarbonyl(v) acyloxy(vi) phenyl(vii) substituted phenyl in which one or more substituents are X and Y,(viii) alkyl-S(O).sub.n,(ix) cycloalkyl-S(O).sub.n,(x) phenyl-S(O).sub.n,(xi) substituted phenyl-S(O).sub.n in which one or more substituents are X and Y, and(xii) oxo,(c) alkyl-S(O).sub.n,(d) cycloalkyl-S(O).sub.n,(e) phenyl-S(O).sub.n,(f) substituted phenyl-S(O).sub.n in which one or more substituents are X or Y,(g) halogen,(h) hydroxy,(i) alkoxy,(j) alkoxycarbonyl,(k) acyloxy,(l) phenyl, and(m) substituted phenyl in which one or more substituents are X and Y,(7) phenyl,(8) substituted phenyl in which one or more substituents are X or Y,(9) amino,(10) alkylamino,(11) dialkylamino,(12) phenylamino,(13) substituted phenylamino in which one or more substituents are X or Y,(14) alkyl(substituted phenyl)amino in which one or more substituents are X and Y,(15) phenylalkylamino,(16) di(phenylalkyl)amino,(17) substituted phenylalkylamino in which one or more substituents are X or Y,(18) a member selected from(a) piperidinyl,(b) pyrrolidinyl,(c) piperazinyl,(d) morpholinyl,(e) thiomorpholino,(f) histaminyl,(g) 3-aminomethyl pyridinyl, and(19) hydroxy substituted alkylamino;X and Y are independently hydrogen, halogen, trifluoromethyl, alkyl, nitro, alkoxy, or cyano;n is 0, 1, or 2;R.sup.4 is ##STR2## M+ is hydrogen, ammonium, or an alkali metal.