公开(公告)号：US06730072B2

公开(公告)日：2004-05-04

申请号：US09867976

申请日：2001-05-30

申请人： Rebecca S. Shawgo ,  Norman F. Sheppard, Jr. ,  Michael J. Cima ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Benjamin F. Polito ,  Scott A. Uhland

发明人： Rebecca S. Shawgo ,  Norman F. Sheppard, Jr. ,  Michael J. Cima ,  John T. Santini, Jr. ,  Stephen J. Herman ,  Benjamin F. Polito ,  Scott A. Uhland

IPC分类号： A61K922

CPC分类号： A61B5/145 ,  A61B5/03 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0097 ,  A61N1/303 ,  B01L3/50853 ,  B01L2300/0819

摘要： Methods and devices are provided for mechanically sealing the reservoirs of microchip devices to prevent leakage from or between any of the reservoirs. In one embodiment, the method includes sandwiching a microchip device and a gasket material covering the reservoir openings between a front sealing frame and a backplate, such that the gasket material is compressed against the back side of the microchip device by the back plate. The front sealing frame is secured to the back sealing plate using fasteners or welding. The gasket material is preferably a flexible polymeric sheet, which is biocompatible and compatible with the reservoir contents. In another embodiment, a composite backplate is used in place of the back sealing plate and separate gasket material. The composite backplate can include a substrate having sealing plugs defined thereon. The composite backplate also can be designed to hold the drug, thereby combining the assembly steps of reservoir filling and sealing.

摘要翻译： 提供了用于机械密封微芯片装置的储存器的方法和装置，以防止任何储存器之间的泄漏。 在一个实施例中，该方法包括在前密封框架和背板之间夹着微芯片装置和覆盖储存器开口的衬垫材料，使得衬垫材料通过后板压靠在微芯片装置的后侧。 前密封框架使用紧固件或焊接固定到后密封板。 垫片材料优选是柔性聚合物片材，其是生物相容性的并且与储存器内容物相容。 在另一个实施例中，使用复合背板来代替后密封板和单独的衬垫材料。 复合背板可以包括其上限定有密封塞的基板。 复合背板也可以设计成保持药物，从而结合储液器填充和密封的组装步骤。

公开(公告)号：US07910151B2

公开(公告)日：2011-03-22

申请号：US11260526

申请日：2005-10-27

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61L33/00

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法及其制造方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 控制释放系统可以结合到可植入药物递送或生物传感装置中。

公开(公告)号：US20090030404A1

公开(公告)日：2009-01-29

申请号：US12243791

申请日：2008-10-01

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物;以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。

公开(公告)号：US20110172587A1

公开(公告)日：2011-07-14

申请号：US13012426

申请日：2011-01-24

申请人： John T. Santini, JR. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, JR. ,  Stephen J. Herman

发明人： John T. Santini, JR. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, JR. ,  Stephen J. Herman

IPC分类号： A61F9/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/0097 ,  H01L24/96 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00

摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.

摘要翻译： 提供了将药物输送到眼睛的方法和系统。 该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。

公开(公告)号：US07510551B2

公开(公告)日：2009-03-31

申请号：US10641507

申请日：2003-08-15

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

公开(公告)号：US08211092B2

公开(公告)日：2012-07-03

申请号：US12243791

申请日：2008-10-01

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry M. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry M. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物，以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。

公开(公告)号：US07455667B2

公开(公告)日：2008-11-25

申请号：US11259301

申请日：2005-10-26

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

公开(公告)号：US06976982B2

公开(公告)日：2005-12-20

申请号：US10042996

申请日：2002-01-09

申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman

发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman

IPC分类号： A61F9/007 ,  A61K9/00 ,  A61M37/00 ,  A61K9/22 ,  A61B5/05 ,  A61M31/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/0097 ,  H01L24/96 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00

摘要： Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices, such as a sensor or a component thereof. Preferably, the microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules to and into the eye of a patient in need thereof.

摘要翻译： 提供可以符合曲面的Microchip器件阵列用于控制释放或暴露储层内容物。 阵列包括两个或更多个微芯片器件元件，每个微芯片器件元件包括多个储存器，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接器件元件的装置。 储存器可以包含一种或多种药物和/或一个或多个次要装置，例如传感器或其组件。 优选地，微芯片装置包含并可控地释放出有需要的患者眼睛中的治疗，预防和诊断分子。

公开(公告)号：US07497846B2

公开(公告)日：2009-03-03

申请号：US11005391

申请日：2004-12-06

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

IPC分类号： A61M5/00 ,  A61K9/22

CPC分类号： A61K9/0097

摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

公开(公告)号：US06827250B2

公开(公告)日：2004-12-07

申请号：US10184259

申请日：2002-06-28

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  Stephen J. Herman ,  John T. Santini, Jr. ,  John M. Maloney

IPC分类号： B23K106

CPC分类号： A61K9/0097

摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.

摘要翻译： 提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。 在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置 为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。