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    Substituted 3,4-dihydro-2H-benzopyrans, processes for their preparation, their use and pharmaceutical products based on these compounds
    2.
    发明授权
    Substituted 3,4-dihydro-2H-benzopyrans, processes for their preparation, their use and pharmaceutical products based on these compounds 失效
    取代的3,4-二氢-2H-苯并吡喃，其制备方法及其用途和基于这些化合物的药物产品

    公开(公告)号：US4999371A

    公开(公告)日：1991-03-12

    申请号：US151584

    申请日：1988-02-02

    申请人： Heinrich C. Englert ,  Hans-Jochen Lang ,  Dieter Mania ,  Bernward Scholkens

    发明人： Heinrich C. Englert ,  Hans-Jochen Lang ,  Dieter Mania ,  Bernward Scholkens

    IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D405/04 ,  C07D409/14

    CPC分类号： C07D405/04 ,  C07D409/14

    摘要： 3,4-Dihydro-2H-benzo[b]pyrans of the formula I ##STR1## are described, in which R.sup.1 is H, OH, (C.sub.1 -C.sub.2)-alkoxy, (C.sub.1 -C.sub.2)-alkyl or NR.sup.4 R.sup.5,R.sup.4 and R.sup.5 being identical or different and representing H, (C.sub.1 -C.sub.2)-alkyl or (C.sub.1 -C.sub.3)-alkylcarbonyl,R.sup.2 and R.sup.3 are identical or different and are alkyl having 1-4 carbon atoms,Ar is an aromatic or heteroaromatic system which is unsubstituted or substituted,n is 1 or 2 andX is a (CH.sub.2).sub.r chain which can be interrupted by a heteroatom O, S or NR.sup.6, R.sup.6 being H or (C.sub.1 -C.sub.4)-alkyl andr being one of the numbers 2, 3, 4 or 5.Processes for the preparation of these compounds, their use and pharmaceutical products based on these compounds are also described.

    摘要翻译： 描述了式I的3,4-二氢-2H-苯并[b]吡喃，其中R 1是H，OH，（C 1 -C 2） - 烷氧基，（C 1 -C 2） - 烷基或NR 4 R 5， R4和R5相同或不同，代表H，（C1-C2） - 烷基或（C1-C3） - 烷基羰基，R2和R3相同或不同，是具有1-4个碳原子的烷基，Ar是芳族或杂芳族 系统是未取代或取代的，n是1或2，X是可以被杂原子O，S或NR6中间的（CH2）r链，R6是H或（C1-C4） - 烷基，r是 编号2,3,4或5.还描述了这些化合物的制备方法及其用途和基于这些化合物的药物产品。

    Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs
    4.
    发明授权
    Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs 失效
    使用取代的3,4-二氢-2H-苯并吡喃作为肺部阻塞性功能障碍的补救措施

    公开(公告)号：US5364878A

    公开(公告)日：1994-11-15

    申请号：US4648

    申请日：1993-01-14

    申请人： Heinrich C. Englert ,  Erik Klaus ,  Dieter Mania ,  Bernward Scholkens

    发明人： Heinrich C. Englert ,  Erik Klaus ,  Dieter Mania ,  Bernward Scholkens

    IPC分类号： A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55

    CPC分类号： A61K31/42 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  Y10S514/826

    摘要： The use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs and/or disorders of the efferent urinary passagesThe use of 3,4-dihydro-2H-benzo[b]pyrans of the formula I ##STR1## in which R.sup.1 represents H, OH, (C.sub.1 -C.sub.2)-alkoxy, (C.sub.1 -C.sub.2)-alkyl or NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are identical or different and represent H, (C.sub.1 -C.sub.2)-alkyl or (C.sub.1 -C.sub.3)-alkyl-carbonyl,R.sup.2 and R.sup.3 are identical or different and represent alkyl having 1-4 carbon atoms,Ar represents an aromatic or heteroaromatic system which is unsubstituted or substituted by 1 to 3 identical or different radicals (C.sub.1 -C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy, halogen, trifluoromethyl, CN, NO.sub.2, CO--(C.sub.1 -C.sub.2)-alkyl or SO.sub.m --(C.sub.1 -C.sub.2)-alkyl with m=1 or 2,n represents 1 or 2,X represents a chain (CH.sub.2).sub.r which can be interrupted by a heteroatom O, S or NR.sup.6, where R.sup.6 denotes H or (C.sub.1 -C.sub.4)-alkyl, and r represents the numbers 2, 3, 4 or 5,for the preparation of a remedy for obstructive functional disorders of the lungs and/or disorders of the efferent urinary passages, is described.

    摘要翻译： 使用取代的3,4-二氢-2H-苯并吡喃作为肺部阻塞性功能障碍的补救措施和/或传出的尿道的障碍使用式（I）的3,4-二氢-2H-苯并[b]吡喃 其中R 1表示H，OH，（C 1 -C 2） - 烷氧基，（C 1 -C 2） - 烷基或NR 4 R 5，其中R 4和R 5相同或不同并且表示H，（C 1 -C 2） - 烷基 或（C 1 -C 3） - 烷基 - 羰基，R 2和R 3相同或不同并且表示具有1-4个碳原子的烷基，Ar表示未被取代或被1至3个相同或不同基团取代的芳族或杂芳族体系 （C 1 -C 2） - 烷基，（C 1 -C 2） - 烷氧基，卤素，三氟甲基，CN，NO 2，CO-（C 1 -C 2） - 烷基或SO m-（C 1 -C 2） - 烷基，m = 1或2，X表示可以被杂原子O，S或NR6中断的链（CH 2）r，其中R 6表示H或（C 1 -C 4） - 烷基，r表示数2，3，4或5 ，用于制备肺部阻塞性功能障碍的补救措施 描述了传出尿道的d /或紊乱。

    2-Aminomethyl-6-sulfamoylphenol derivatives with salidiuretic activities
    6.
    发明授权
    2-Aminomethyl-6-sulfamoylphenol derivatives with salidiuretic activities 失效
    2-氨基甲基-6-磺酰基苯酚衍生物，具有耐盐水活性

    公开(公告)号：US4766241A

    公开(公告)日：1988-08-23

    申请号：US102793

    申请日：1987-09-23

    申请人： Heinrich C. Englert ,  Dieter Mania ,  Roman Muschaweck ,  Max Hropot

    发明人： Heinrich C. Englert ,  Dieter Mania ,  Roman Muschaweck ,  Max Hropot

    IPC分类号： A61K31/18 ,  A61K31/40 ,  A61P3/00 ,  A61P7/10 ,  A61P9/12 ,  C07C67/00 ,  C07C301/00 ,  C07C303/02 ,  C07C303/38 ,  C07C303/40 ,  C07C311/15 ,  C07C311/37 ,  C07D295/22 ,  C07D295/26 ,  C07C143/80

    CPC分类号： C07D295/26 ,  C07C309/00

    摘要： The invention relates to 2-aminomethylphenols of the formula I ##STR1## in which R.sup.1 and R.sup.2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or benzyl which is optionally substituted by alkyl, alkoxy or halogen, R.sup.3 and R.sup.5 denote hydrogen, halogen, alkyl or alkoxy, R.sup.4 denotes halogen, alkyl or cycloalkyl and R.sup.6 and R.sup.7 represent hydrogen or alkyl, it being possible for the radicals R.sup.1 and R.sup.2, R.sup.6 R.sup.7 and/or two of the radicals R.sup.3, R.sup.4 and R.sup.5 to form an alkylene chain which is optionally substituted by methyl groups and which, in the case of the radicals R.sup.1, R.sup.2, R.sup.6 and R.sup.7, can also be interrupted by oxygen atoms, sulfur atoms and/or imino groups, and to physiologically acceptable salts thereof, a process for their preparation, and their use and to pharmaceutical formulations based on these compounds.

    摘要翻译： 本发明涉及式I的2-氨基甲基苯酚，其中R 1和R 2表示氢，烷基，烯基，炔基，环烷基或苄基，其任选被烷基，烷氧基或卤素取代，R 3和R 5表示氢，卤素， 烷基或烷氧基，R 4表示卤素，烷基或环烷基，R 6和R 7表示氢或烷基，基团R 1和R 2，R 6 R 7和/或基团R 3，R 4和R 5中的两个可以形成亚烷基链， 任选被甲基取代，并且在基团R 1，R 2，R 6和R 7的情况下，也可以被氧原子，硫原子和/或亚氨基基团及其生理上可接受的盐中断， 制剂及其用途以及基于这些化合物的药物制剂。

    Substituted benzo[b]pyrans, processes for their preparation, their use and pharmaceutical preparations based on these compounds
    9.
    发明授权
    Substituted benzo[b]pyrans, processes for their preparation, their use and pharmaceutical preparations based on these compounds 失效
    取代的苯甲（B）PYRANS，其制备方法，其使用和基于这些化合物的药物制备

    公开(公告)号：US5130310A

    公开(公告)日：1992-07-14

    申请号：US467547

    申请日：1990-01-19

    申请人： Klaus Weidman ,  Heinrich C. Englert ,  Bernward Scholkens ,  Martin Bickel

    发明人： Klaus Weidman ,  Heinrich C. Englert ,  Bernward Scholkens ,  Martin Bickel

    IPC分类号： C07D263/22 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61P9/12 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    CPC分类号： C07D405/04 ,  C07D413/04

    摘要： Benzo[b]pyran derivatives of the formula I ##STR1## with E--D equal to CH--CHOH or C.dbd.CH;X equal to oxygen or sulfur;Y equal to oxygen, sulfur, SO, SO.sub.2 or NR.sup.9 ;R.sup.1 equal to CN, NO.sub.2, Hal, alkoxycarbonyl, SO.sub.1-2 -alkyl or SO.sub.1-2 -aryl;R.sup.2 equal to H, OH, alkoxy, alkyl, Hal, NR.sup.10 R.sup.11 ;R.sup.3 /R.sup.4 equal to alkyl;R.sup.5 /R.sup.6 equal to alkyl, (CH.sub.2).sub.1-6 COO-alkyl, (CH.sub.2).sub.1-6 CONR.sup.10 R.sup.11, (CH.sub.2).sub.0-6 COOH, (CH.sub.2).sub.1-6 CO-alkyl, CO.sub.2 -alkyl, alkylmercaptoalkyl, alkylsulfi(i)(o)nyl, hydroxyalkyl, mercaptoalkyl, aminoalkyl, N-(di)-alkylaminoalkyl or (CH.sub.2).sub.f Ar with f equal to zero-3;R.sup.7 /R.sup.8 equal to hydrogen, alkyl or phenyl, and m equal to zero-2are outstanding antihypertensives and spasmolytics. Preparation processes and use are described.

    摘要翻译： 式I的苯并[b]吡喃衍生物，其中E-D等于CH-CHOH或C = CH; X等于氧或硫; Y等于氧，硫，SO，SO2或NR9; R1等于CN，NO2，Hal，烷氧基羰基，SO1-2-烷基或SO1-2-芳基; R2等于H，OH，烷氧基，烷基，Hal，NR10R11; R3 / R4等于烷基; （CH 2）1-6 CONR 10 R 11，（CH 2）0-6COOH，（CH 2）1-6 CO-烷基，CO 2 - 烷基，烷基巯基烷基，烷基亚磺酸（i）（ o）n，羟基烷基，巯基烷基，氨基烷基，N-（二） - 烷基氨基烷基或（CH2）fAr，f等于零-3; R7 / R8等于氢，烷基或苯基，m等于零-2是杰出的抗高血压药和解痉药。 描述制备方法和用途。