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1.发明申请公开(公告)号：US20110159041A1
公开(公告)日：2011-06-30
申请号：US13036310
申请日：2011-02-28
申请人： Remy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Remy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： A61K39/118 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/295 , C07K16/12 , A61K38/16 , C12N9/10 , C07H21/00 , C12P21/00 , C12Q1/68 , G01N33/53 , A61P31/04 , A61P37/04
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。
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公开(公告)号：US07601531B2
公开(公告)日：2009-10-13
申请号：US11366942
申请日：2006-03-02
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
CPC分类号： C07K14/295 , A01K2217/05 , A61K39/00
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.
摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。
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3.发明授权Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染公开(公告)号：US08143024B2
公开(公告)日：2012-03-27
申请号：US13036310
申请日：2011-02-28
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12P21/06 , C12N15/09 , C07H21/04 , A61K39/118
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。
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4.发明授权Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染公开(公告)号：US07910329B2
公开(公告)日：2011-03-22
申请号：US12491474
申请日：2009-06-25
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
IPC分类号： C12N15/09 , C12N1/20 , C12P21/04 , C07H21/04 , A61K39/118
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。
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公开(公告)号：US07101963B2
公开(公告)日：2006-09-05
申请号：US10289762
申请日：2002-11-07
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
CPC分类号： C07K14/295 , A01K2217/05 , A61K39/00
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.
摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。
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6.发明授权Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection 有权沙眼衣原体基因组序列和多肽，其片段及其用途，特别是用于诊断，预防和治疗感染公开(公告)号：US07575913B2
公开(公告)日：2009-08-18
申请号：US11366965
申请日：2006-03-02
申请人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
发明人： Rémy Griffais , Susan K. Hoiseth , Robert J. Zagursky , Benjamin J. Metcalf , Joel A. Peek , Banumathi Sankaran , Leah D. Fletcher
CPC分类号： C07K14/295
摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.
摘要翻译： 本发明的主题是编码沙眼衣原体的多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程或毒力中涉及代谢，或由其编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及沙眼衣原体基因组的转录基因产物，例如反义和核酶分子，其可用于控制微生物的生长。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断沙眼衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌特别是沙眼衣原体感染的药物，特别是疫苗组合物。
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7.发明授权Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity 失效不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性公开(公告)号：US07615229B2
公开(公告)日：2009-11-10
申请号：US10507786
申请日：2003-03-13
IPC分类号： A61K39/02
CPC分类号： A61K39/102 , A61K38/00 , A61K39/00 , C07K14/285 , C07K16/1242
摘要： A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
摘要翻译： 具有降低的酶活性并诱导野生型P4蛋白的抗体和/或对非特异性流感嗜血杆菌（NTHi）具有良好杀菌活性的P4变体蛋白质可用作人类免疫原性组合物中的活性成分。 还提供了使用这些蛋白质的方法，以及含有它们与其它抗原组合的组合物。
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8.发明申请MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITY 失效具有降低酶活性的不可分泌HAEMOPHILUS INFLUENZAE的P4蛋白的突变体公开(公告)号：US20090148465A1
公开(公告)日：2009-06-11
申请号：US12336995
申请日：2008-12-17
CPC分类号： A61K39/102 , A61K38/00 , A61K39/00 , C07K14/285 , C07K16/1242
摘要： A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
摘要翻译： 具有降低的酶活性并诱导野生型P4蛋白的抗体和/或对非特异性流感嗜血杆菌（NTHi）具有良好杀菌活性的P4变体蛋白质可用作人类免疫原性组合物中的活性成分。 还提供了使用这些蛋白质的方法，以及含有它们与其它抗原组合的组合物。
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9.发明授权Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity 失效不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性公开(公告)号：US07666626B2
公开(公告)日：2010-02-23
申请号：US12336995
申请日：2008-12-17
IPC分类号： C12P21/06
CPC分类号： A61K39/102 , A61K38/00 , A61K39/00 , C07K14/285 , C07K16/1242
摘要： A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
摘要翻译： 具有降低的酶活性并诱导野生型P4蛋白的抗体和/或对非特异性流感嗜血杆菌（NTHi）具有良好杀菌活性的P4变体蛋白质可用作人类免疫原性组合物中的活性成分。 还提供了使用这些蛋白质的方法，以及含有它们与其它抗原组合的组合物。
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