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    Implant and agent delivery device
    1.
    发明申请
    Implant and agent delivery device 审中-公开
    植入物和药剂输送装置

    公开(公告)号：US20050060019A1

    公开(公告)日：2005-03-17

    申请号：US10951735

    申请日：2004-09-28

    申请人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Sean Forde

    发明人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Sean Forde

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/88

    CPC分类号： A61F2/88 ,  A61F2/06 ,  A61F2/2493 ,  A61F2220/0016 ,  A61F2250/0067

    摘要： The present invention provides a system (178) for delivering a therapeutic agent in combination with an implantable device (2) to maximize a therapeutic benefit offered by each. Preferably, the therapeutic agent is contained within a solid matrix form such as a pellet or gel to facilitate its handling and to regulate its rate of dissipation into the tissue after delivery. The implant device (2) is specially configured to receive and retain the matrix but permit blood to interact with the matrix so that the agent can be released to the blood in and around the device and the surrounding tissue. A delivery system (178) comprises an implant delivery device having an obturator (180) capable of piercing the tissue and an agent matrix delivery device (210) to place a matrix form, such as a pellet, into the interior of the implant (2) after it has been implanted. Preferably, the implant delivery device (180) and the matrix delivery device (210) are contained in one apparatus to facilitate delivery of the pellet into the embedded implant. The present invention is useful for treating tissue in any area of the body, especially ischemic tissue experiencing reduced blood flow. The present devices and methods are especially useful for treatment of ischemia of the myocardium. In treatment of the myocardium, the present implant device and matrix combination may be delivered surgically through the epicardium of the heart.

    摘要翻译： 本发明提供了一种用于将治疗剂与可植入装置（2）组合递送以最大化由每个提供的治疗益处的系统（178）。 优选地，治疗剂包含在固体基质形式例如丸粒或凝胶中，以促进其处理并调节其在分娩后向组织中的耗散速率。 植入装置（2）被特别地构造成接收和保持基质，但允许血液与基质相互作用，使得试剂可以释放到装置周围的组织和周围的组织中和周围。 递送系统（178）包括植入物递送装置，其具有能够刺穿组织的闭孔器（180）和药剂矩阵输送装置（210），以将诸如颗粒的矩阵形式放置在植入物（2）的内部 ）植入后。 优选地，植入物递送装置（180）和基质递送装置（210）被包含在一个装置中以便于将颗粒递送到嵌入的植入物中。 本发明可用于治疗身体的任何区域中的组织，特别是经历血流减少的缺血组织。 本发明的装置和方法对于治疗心肌缺血特别有用。 在心肌的治疗中，本发明的植入装置和基质组合可以通过心脏的心外膜手术递送。

    Flexible vascular inducing implants
    2.
    发明申请
    Flexible vascular inducing implants 审中-公开
    柔性血管诱导植入物

    公开(公告)号：US20050004558A1

    公开(公告)日：2005-01-06

    申请号：US10899368

    申请日：2004-07-26

    申请人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Richard Choh ,  Sean Forde

    发明人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Richard Choh ,  Sean Forde

    IPC分类号： A61B17/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/94 ,  A61K9/22 ,  A61L27/00 ,  A61M37/00

    CPC分类号： A61F2/94 ,  A61F2/2493 ,  A61F2230/0091 ,  A61F2250/0067

    摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

    摘要翻译： 提供了用于促进缺血组织中血管生成的植入物和相关递送系统。 植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏的心肌。 植入物被构造成具有柔性的，使得它们随着植入其中的周围组织的相应运动而压缩和扩张。 血液进入植入物的流动以及血液在植入物中和周围的汇集导致血栓形成和纤维蛋白生长，这是导致植入物周围组织血管生成的愈合过程。 此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。

    Suture clips, delivery devices and methods
    4.
    发明申请
    Suture clips, delivery devices and methods 审中-公开
    缝合夹，输送装置和方法

    公开(公告)号：US20070093858A1

    公开(公告)日：2007-04-26

    申请号：US11604944

    申请日：2006-11-28

    申请人： Richard Gambale ,  Michael Weiser ,  Edward Page ,  Alexander Kolnick

    发明人： Richard Gambale ,  Michael Weiser ,  Edward Page ,  Alexander Kolnick

    IPC分类号： A61B17/10

    CPC分类号： A61B17/0487 ,  A61B17/0467 ,  A61B17/0469 ,  A61B2017/0417 ,  A61B2017/0424 ,  A61B2017/0445 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0459 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  Y10T24/3969

    摘要： Suture clips and suture clip loading, delivery, locking and severing devices in both catheter and endoscopic embodiments are disclosed that permit the delivery and application of suture clips directly in contact with or in close approximation to sutured tissue. The catheter or endoscopic versions incorporate a collet cage with a plurality of flexible collet fingers that captivate a suture clip ring and a suture clip plug for assembly with a suture. An outer sliding sleeve constrains the collet fingers when distally advanced to minimize potential trauma during delivery and assembly of the suture clip in close proximity to the stitched tissue. Proximal retraction of the sliding sleeve coupled with the distal advancement of a pusher against cam surfaces on the inner walls of the collet fingers causes the collet fingers to open. The catheter is designed to hold and assemble the suture clip in a first position and release the suture clip and sever the suture ends proximal to the suture clip in a second position. Single pusher two-step embodiments and double pusher three-step embodiments are disclosed. Suture clip designs with plugs having heads for use with the suture clip delivery catheter are also disclosed. A suture clip loading device for loading suture clip components into the delivery system as well as a threader for threading sutures into the suture clip systems are also disclosed. A method of loading, delivering and deploying suture clips is further disclosed.

    摘要翻译： 公开了导管和内窥镜实施例中的缝合夹和缝合夹装载，递送，锁定和切断装置，其允许缝合夹直接与缝合组织接触或接近近似地递送和施加。 导管或内窥镜版本包括具有多个柔性夹头的夹头保持器，其夹持缝合夹环和缝合夹塞以与缝合线组装。 外滑动套筒在向远侧前进时约束夹头，以最小化缝合夹在紧靠缝合组织的递送和组装期间的潜在创伤。 与推动器的远端前进部联接的滑动套筒的近端缩回抵靠夹头指状物的内壁上的凸轮表面使得夹头指状物打开。 导管被设计成将缝合夹保持并组装在第一位置，并释放缝合夹并在第二位置将缝合线端部切割成缝合线夹。 公开了单推杆两步实施例和双推动器三步实施例。 还公开了具有插头的缝合夹设计，其具有用于缝合夹输送导管的头部。 还公开了一种用于将缝合夹组件加载到输送系统中的缝线夹装载装置以及用于将缝线穿入缝合夹系统的穿线器。 进一步公开了一种加载，递送和部署缝合夹的方法。

    Stent delivery catheter
    9.
    发明申请
    Stent delivery catheter 审中-公开
    支架输送导管

    公开(公告)号：US20050049608A1

    公开(公告)日：2005-03-03

    申请号：US10867428

    申请日：2004-06-14

    申请人： Harold Aznoian ,  Michael Weiser

    发明人： Harold Aznoian ,  Michael Weiser

    IPC分类号： A61F2/04 ,  A61F2/94 ,  A61F11/00 ,  A61M20060101

    CPC分类号： A61F2/95 ,  A61F2/07 ,  A61F2/94 ,  A61F2002/041 ,  A61F2002/9505

    摘要： A delivery device for a biliary stent constructed of thermoplastic material with ridges and valleys formed along the outer surface of the stent that provide a helical, thread-like configuration. The delivery device comprises an external surface that is selectively expandable to engage an interior surface of the tubular stent. Additionally the exterior surface may include ridges and valleys that coincide with ridges and valleys defined by the helical thread extending through the stent in order to provide a more secure engagement with the stent during delivery.

    摘要翻译： 用于由热塑性材料构成的胆管支架的输送装置，所述热塑性材料具有沿支架的外表面形成的具有螺旋状的线状构造的脊和谷。 输送装置包括外表面，其被选择性地可膨胀以接合管状支架的内表面。 此外，外表面可以包括与由延伸穿过支架的螺旋螺纹限定的脊和谷重合的脊和谷，以便在递送期间提供与支架更牢固的接合。