公开(公告)号：US4802491A

公开(公告)日：1989-02-07

申请号：US891653

申请日：1986-07-30

申请人： Richard J. Cohen ,  Joseph M. Smith

发明人： Richard J. Cohen ,  Joseph M. Smith

IPC分类号： A61B5/0436 ,  A61B5/0452 ,  G06F17/00 ,  A61B5/04

CPC分类号： A61B5/04525 ,  A61B5/0436

摘要： Myocardial electrical stability is assessed based on the derivation of an alternating ECG morphology index from a series of heartbeats. The ECG electrical signal waveform is digitized at a plurlaity of sample points for each of the series of beats. Sample point matrices from the digitized ECG signals are constructed and the alternating energy at each of the sample points for the series of beats is computed. The alternating energy over the entire set of sample points is summed to generate the total alternating energy. This total alternating energy is normalized with respect to the energy of the average waveform, the normalized value being the alternating ECG morphology index. Animal studies indicate a high negative correlation between cardiac electrical stability and the alternating ECG morphology index.

公开(公告)号：US20100145206A1

公开(公告)日：2010-06-10

申请号：US12630735

申请日：2009-12-03

申请人： Lahn Fendelander ,  Ali Haghighi-Mood ,  Richard J. Cohen

发明人： Lahn Fendelander ,  Ali Haghighi-Mood ,  Richard J. Cohen

IPC分类号： A61B5/0402 ,  A61B5/02

CPC分类号： A61B5/0452 ,  A61B5/7275 ,  G16H50/20

摘要： One or more electrocardiographic signals are detected from a subject. The occurrence of alternans in the electrocardiographic signals are detected using one or more processors. One or more characteristics of detected alternans are determined. The determined characteristics of the detected alternans are analyzed to determine whether cardiac ischemia is present.

摘要翻译： 从受试者检测一个或多个心电图信号。 使用一个或多个处理器来检测心电图信号中的交替声音的发生。 确定检测到的交替量的一个或多个特征。 分析检测到的交替量的确定特征，以确定是否存在心脏缺血。

公开(公告)号：US20090132557A1

公开(公告)日：2009-05-21

申请号：US11942188

申请日：2007-11-19

申请人： Richard J. Cohen ,  Randolph M. Forlenza

发明人： Richard J. Cohen ,  Randolph M. Forlenza

IPC分类号： G06F7/00

CPC分类号： G06Q10/10

摘要： A system and methodology are provided for using hierarchical groupings to organize governance, risk, and compliance (GRC) policies and rules. The groupings are based on categorizations that can be arbitrarily represented by both predetermined and user-defined hierarchical policy naming schemes. Once GRC regulatory and compliance policies and rules are grouped to accommodate company policies, testing can be designed around groups of policies and/or rules and scheduled to align with schedule and timing requirements. By allowing a policy or rule to be associated with multiple hierarchies, a single execution of a policy or rule can be associated with, managed from, and satisfy multiple regulatory and compliance needs with one effort.

摘要翻译： 提供了一种系统和方法，用于使用分层分组来组织治理，风险和合规（GRC）政策和规则。 分组基于可以由预定和用户定义的分层策略命名方案任意表示的分类。 一旦GRC监管和合规政策和规则被分组以适应公司政策，就可以围绕一组政策和/或规则设计测试，并按计划和时间要求计划。 通过允许将策略或规则与多个层次结构相关联，策略或规则的单个执行可以一次性与多个监管和合规性需求相关联，从而管理并满足多个监管和合规性需求。

公开(公告)号：US6132380A

公开(公告)日：2000-10-17

申请号：US154621

申请日：1998-09-16

申请人： Richard J. Cohen ,  Derin A. Sherman ,  Robert H. Rubin

发明人： Richard J. Cohen ,  Derin A. Sherman ,  Robert H. Rubin

IPC分类号： A61B5/026 ,  A61B5/02 ,  A61B8/00 ,  A61B6/00 ,  A61B5/00

CPC分类号： A61B5/412 ,  A61B5/026 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/726

摘要： Perfusion measurement method. The method includes detecting a signal emanating from the tissue and processing the signal to detect fluctuations substantially spatially correlated on a length scale less than 1 centimeter. The fluctuations are then analyzed to obtain a measure of perfusion. In one embodiment, the detected fluctuations are substantially correlated with fluctuations of a biological parameter such as the cardiac cycle or the respiratory cycle.

摘要翻译： 灌注测量方法。 该方法包括检测从组织发出的信号，并处理信号以检测在小于1厘米的长度尺度上基本空间上相关的波动。 然后分析波动以获得灌注的量度。 在一个实施例中，检测到的波动与诸如心动周期或呼吸周期的生物参数的波动基本相关。

公开(公告)号：US5704365A

公开(公告)日：1998-01-06

申请号：US557883

申请日：1995-11-14

申请人： Paul Albrecht ,  Jeffrey M. Arnold ,  Neil Judell ,  Richard J. Cohen

发明人： Paul Albrecht ,  Jeffrey M. Arnold ,  Neil Judell ,  Richard J. Cohen

IPC分类号： A61B5/0408 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/22 ,  G06F17/00 ,  A61B5/0472

CPC分类号： A61B5/0535 ,  A61B5/0408 ,  A61B5/04085 ,  A61B5/0452 ,  A61B5/222 ,  A61B5/4884 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/721 ,  Y10S128/901

摘要： A method of reducing noise in a signal that represents a physiologic process includes obtaining multiple input signals, measuring a relationship between noise content of the input signals, and combining the input signals in consideration of the measured relationship to produce an output signal having low noise content. The multiple input signals may include, for example, two or more primary physiologic input signals or one or more primary physiologic input signals and two or more secondary input signals that represent noise. The method may further include dividing one or more ECG input signals and secondary input signals into set of segments, where each set of segments represents a beat of the ECG signal, measuring a relationship between noise content of corresponding points from successive sets of segments, and combining the input signals based on the measured relationship.

摘要翻译： 一种降低代表生理过程的信号中的噪声的方法包括获得多个输入信号，测量输入信号的噪声含量之间的关系，以及考虑到所测量的关系来组合输入信号，以产生具有低噪声含量的输出信号 。 多个输入信号可以包括例如两个或更多个原始生理输入信号或一个或多个原始生理输入信号以及表示噪声的两个或更多次级输入信号。 该方法还可以包括将一个或多个ECG输入信号和次要输入信号划分成一组段，其中每组段表示ECG信号的搏动，测量来自连续的段的组的对应点的噪声含量之间的关系，以及 根据测量的关系组合输入信号。

公开(公告)号：US5570696A

公开(公告)日：1996-11-05

申请号：US187275

申请日：1994-01-26

申请人： Jeffrey M. Arnold ,  Paul Albrecht ,  Kevin S. Librett ,  Richard J. Cohen

发明人： Jeffrey M. Arnold ,  Paul Albrecht ,  Kevin S. Librett ,  Richard J. Cohen

IPC分类号： A61B5/0408 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/22 ,  G06F17/00

CPC分类号： A61B5/222 ,  A61B5/0408 ,  A61B5/0452 ,  A61B5/0535

摘要： The temporal pattern of cycle-to-cycle variability in physiologic waveforms, such as alternans, is assessed by applying transducers to a subject, recording physiologic signals, and analyzing the cycle-to-cycle variation in waveform morphology. Preferred embodiments include the application of physiologic stress to the subject in order to adjust heart rate to the desired range, real-time analysis of waveform variability, reduction in the effect of intercycle variability on waveform variability, improved techniques for determining the statistical significance of the amplitude of a temporal pattern of variability, handling of abnormal beats such as atrial and ventricular premature beats, and assessment of the statistical significance of a measured level of a temporal pattern of variability.

摘要翻译： 通过对受试者应用传感器，记录生理信号和分析波形形态中的循环周期变化来评估生理波形（例如交替量）中周期与周期的变化的时间模式。 优选的实施方案包括对受试者施加生理应激以便将心率调节至所需范围，波形变异性的实时分析，周期变异性对波形变异性的影响的降低，用于确定波形变异性的统计学意义的改进技术 变异性的时间模式的幅度，异常搏动的处理，例如心房和心室过早搏动，以及评估变化性时间模式的测量水平的统计学显着性。

公开(公告)号：US4930517A

公开(公告)日：1990-06-05

申请号：US343404

申请日：1989-04-25

申请人： Richard J. Cohen ,  Marvin L. Appel ,  Ronald D. Berger

发明人： Richard J. Cohen ,  Marvin L. Appel ,  Ronald D. Berger

IPC分类号： A61B5/0205 ,  G06F17/00

CPC分类号： A61B5/0205 ,  A61B5/7257

摘要： A method and apparatus for estimating transfer functions among multiple physiologic or biologic signals in the presence of feedback. The invention comprises the injection of broad band purturbation into one or more of the subsystems under study, and measuring signals from the subsystems. These signals are transformed to generate a new set of n signals. Casual transfer functions between the signals and additive noise sources are used to represent the relationships between the n signals. Parametric system identification techniques are then used to characterize quantitatively at least two casual transfer functions and noise sources. This method and apparatus provides a powerful tool with which to characterize the interactions of subsystems in the presence of feedback.

摘要翻译： 一种用于在存在反馈的情况下估计多个生理或生物信号之间的传递函数的方法和装置。 本发明包括向被研究的一个或多个子系统注入宽频带的干扰，并测量来自子系统的信号。 这些信号被变换以产生一组新的n个信号。 信号和加性噪声源之间的偶然传递函数用于表示n个信号之间的关系。 然后使用参数系统识别技术来定量地表征至少两个临时传递函数和噪声源。 该方法和设备提供了一个强大的工具，用于表征子系统在存在反馈的情况下的相互作用。

公开(公告)号：US4732157A

公开(公告)日：1988-03-22

申请号：US897602

申请日：1986-08-18

申请人： Daniel T. Kaplan ,  Richard J. Cohen

发明人： Daniel T. Kaplan ,  Richard J. Cohen

IPC分类号： A61B5/0452 ,  A61B5/08 ,  A61B5/087 ,  G06F17/00 ,  G01R23/02

CPC分类号： A61B5/044 ,  A61B5/02405 ,  A61B5/046 ,  A61B5/7275

摘要： Myocardial electrical stability is assessed by sampling an ECG waveform at corresponding fiducial locations for a plurality of beats and creating a scatter plot of the i.sup.th sample versus the (i- 1)th sample. A parameter .lambda. is determined which minimizes the sum of the total distances of the points of the scatter plot to an equation x(i)= 4.lambda.x(i- 1)[ 1-x(i- 1)]. The value of the parameter .lambda. is related to the electrical stability of the heart.

摘要翻译： 通过在多个拍子的相应基准位置采样ECG波形来评估心肌电稳定性，并创建第i个样本与第（i-1）个样本的散点图。 确定最小化散点图点的总距离与等式x（i）=4λx（i-1）[1-x（i-1）]的参数λ。 参数λ的值与心脏的电气稳定性有关。

公开(公告)号：US09591984B2

公开(公告)日：2017-03-14

申请号：US12630718

申请日：2009-12-03

申请人： Richard J. Cohen ,  Ali Haghighi-Mood

发明人： Richard J. Cohen ,  Ali Haghighi-Mood

IPC分类号： A61B5/0452 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/7203

摘要： First cardiac signal data generated from measured heart beats of a subject is received. Characteristics of alternans occurring in the received first cardiac signal data are determined. Second cardiac signal data generated from measured heart beats of the subject after a change relating to an administration of a pharmacological agent is received. Characteristics of alternans occurring in the received second cardiac signal data are determined. The characteristics of alternans occurring in the received first cardiac signal data are compared with the characteristics of alternans occurring in the received second cardiac signal data.

摘要翻译： 接收从受检者的测量心跳产生的第一心脏信号数据。 确定在接收到的第一心脏信号数据中发生的交替发生的特征。 在接受与药物剂的施用有关的变化之后，从被测物的测量心跳产生的第二心脏信号数据被接收。 确定在所接收的第二心脏信号数据中发生的交替发生的特征。 在接收的第一心脏信号数据中发生的交替发生的特征与在所接收的第二心脏信号数据中发生的交替发生的特征进行比较。

公开(公告)号：US20110034813A1

公开(公告)日：2011-02-10

申请号：US12903915

申请日：2010-10-13

申请人： Richard J. Cohen ,  Ramakrishna Mukkamala ,  Derin A. Sherman

发明人： Richard J. Cohen ,  Ramakrishna Mukkamala ,  Derin A. Sherman

IPC分类号： A61B5/021 ,  A61B5/0402 ,  A61B5/02

CPC分类号： A61B5/02007 ,  A61B5/02255 ,  A61B5/029 ,  A61B5/0456 ,  A61B5/726

摘要： The present invention provides methods and apparatus for determining a dynamical property of the systemic or pulmonary arterial tree using long time scale information, i.e., information obtained from measurements over time scales greater than a single cardiac cycle. In one aspect, the invention provides a method and apparatus for monitoring cardiac output (CO) from a single blood pressure signal measurement obtained at any site in the systemic or pulmonary arterial tree or from any related measurement including, for example, fingertip photoplethysmography.According to the method the time constant of the arterial tree, defined to be the product of the total peripheral resistance (TPR) and the nearly constant arterial compliance, is determined by analyzing the long time scale variations (greater than a single cardiac cycle) in any of these blood pressure signals. Then, according to Ohm's law, a value proportional to CO may be determined from the ratio of the blood pressure signal to the estimated time constant. The proportional CO values derived from this method may be calibrated to absolute CO, if desired, with a single, absolute measure of CO (e.g., thermodilution). The present invention may be applied to invasive radial arterial blood pressure or pulmonary arterial blood pressure signals which are routinely measured in intensive care units and surgical suites or to noninvasively measured peripheral arterial blood pressure signals or related noninvasively measured signals in order to facilitate the clinical monitoring of CO as well as TPR.

摘要翻译： 本发明提供了使用长时间尺度信息（即从大于单个心动周期的时间尺度的测量获得的信息）来确定全身或肺动脉树的动力特性的方法和装置。 一方面，本发明提供一种用于从在全身或肺动脉树中的任何位置处获得的单个血压信号测量值或任何相关测量（包括例如指尖光体积描记术）来监测心输出量（CO）的方法和装置。 根据该方法，通过分析长时间尺度变化（大于单个心动周期）来确定被定义为总外周阻力（TPR）和几乎恒定的动脉顺应性的乘积的动脉树的时间常数 任何这些血压信号。 然后，根据欧姆定律，可以根据血压信号与估计的时间常数的比率确定与CO成比例的值。 如果需要，从该方法得到的比例CO值可以通过CO的单一绝对测量（例如，热稀释）校准为绝对CO。 本发明可以应用于在重症监护病房和手术套件中常规测量的侵入性桡动脉血压或肺动脉血压信号，或应用于非侵入性测量的外周动脉血压信号或相关非侵入性测量信号，以便于临床监测 的CO以及TPR。