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公开(公告)号：US5723598A
公开(公告)日：1998-03-03
申请号：US665511
申请日：1996-06-18
申请人： Richard Lerner , Kim Janda , Sydney Brenner
发明人： Richard Lerner , Kim Janda , Sydney Brenner
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C07K14/00 , C12N15/09 , C12N15/10 , C12Q1/68 , C40B70/00
CPC分类号： C12N15/1075 , C07H21/00 , C12N15/1062 , B01J2219/00572 , C40B70/00
摘要： The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also described are the bifunctional molecules of the library, and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions.
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公开(公告)号：US5573905A
公开(公告)日：1996-11-12
申请号：US860445
申请日：1992-03-30
申请人： Richard Lerner , Kim Janda , Sydney Brenner
发明人： Richard Lerner , Kim Janda , Sydney Brenner
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C07K14/00 , C12N15/09 , C12N15/10 , C12Q1/68 , C40B70/00
CPC分类号： C12N15/1075 , C07H21/00 , C12N15/1062 , B01J2219/00572 , C40B70/00
摘要： The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also described are the bifunctional molecules of the library, and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions.
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公开(公告)号：US6060596A
公开(公告)日：2000-05-09
申请号：US33743
申请日：1998-03-03
申请人： Richard Lerner , Kim Janda , Sydney Brenner
发明人： Richard Lerner , Kim Janda , Sydney Brenner
IPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C07K14/00 , C12N15/09 , C12N15/10 , C12Q1/68 , C40B70/00
CPC分类号： C12N15/1075 , C07H21/00 , C12N15/1062 , B01J2219/00572 , C40B70/00
摘要： The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also described are the bifunctional molecules of the library, and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions.
摘要翻译： 本发明描述了一种编码的组合化学文库，其由多个具有化学聚合物和限定化学聚合物结构的识别寡核苷酸序列的双功能分子组成。 还描述了文库的双功能分子，以及使用该文库来鉴定文库内与预选结合相互作用结合生物活性分子的化学结构的方法。
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公开(公告)号：US20060257856A1
公开(公告)日：2006-11-16
申请号：US11315970
申请日：2005-12-22
申请人： Angray Kang , Carlos Barbas , Richard Lerner
发明人： Angray Kang , Carlos Barbas , Richard Lerner
CPC分类号： C40B40/02 , C07K14/705 , C07K16/00 , C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2319/02 , C12N15/1037 , C12P19/34
摘要： Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a filamentous phage coat protein membrane anchor domain fused to at least one of the polypeptides.
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公开(公告)号：US20060217359A1
公开(公告)日：2006-09-28
申请号：US11369206
申请日：2006-03-06
申请人： Paul Wentworth , Richard Lerner
发明人： Paul Wentworth , Richard Lerner
IPC分类号： A61K31/57 , A61K31/365 , A61K31/12 , A61K31/045
CPC分类号： C07J61/00 , C07C49/523 , C07C49/757 , C07C59/353 , C07D313/04 , C07J9/00 , C07J9/005
摘要： As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cytotoxic cholesterol oxidation or ozonation products. The present application is directed to the products of cholesterol ozonation, binding entities directed against such products, and methods of using such binding entities and cytotoxins to treat a variety of diseases.
摘要翻译： 如本文所示，当胆固醇存在于动脉粥样硬化斑块中时，胆固醇被氧化。 该反应产生细胞毒性胆固醇氧化或臭氧化产物。 本申请涉及胆固醇臭氧化产物，针对这些产品的结合实体，以及使用这些结合实体和细胞毒素治疗各种疾病的方法。
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公开(公告)号：US20070009537A1
公开(公告)日：2007-01-11
申请号：US10534575
申请日：2003-11-13
申请人： Paul Wentworth , Richard Lerner
发明人： Paul Wentworth , Richard Lerner
CPC分类号： A61K33/40 , A61K39/40 , A61K39/42 , A61K2039/505 , C07K16/00 , C07K16/1232 , C07K16/1235 , C07K2317/55 , Y02A50/397 , Y02A50/474 , Y02A50/484
摘要： The invention provides compositions having antibodies that can generate reactive oxygen species when exposed to singlet oxygen, as well as methods of using the compositions, for example, to treat microbial infections.
摘要翻译： 本发明提供具有当暴露于单线态氧时可产生活性氧物种的抗体的组合物，以及使用该组合物例如治疗微生物感染的方法。
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公开(公告)号：US20060292076A1
公开(公告)日：2006-12-28
申请号：US10534574
申请日：2003-11-13
申请人： Paul Wentworth , Richard Lerner
发明人： Paul Wentworth , Richard Lerner
CPC分类号： A61K49/0004 , G01N33/5047 , G01N33/84
摘要： The invention provides methods of detecting antibodies and neutrophils that can generate reactive oxygen species.
摘要翻译： 本发明提供检测能产生活性氧的抗体和嗜中性粒细胞的方法。
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8.发明申请Methods for producing polypeptide binding sites, monoclonal antibodies and compositions thereof 审中-公开产生多肽结合位点的方法，单克隆抗体及其组合物公开(公告)号：US20060121570A1
公开(公告)日：2006-06-08
申请号：US11253223
申请日：2005-10-18
申请人： Carlos Barbas , Richard Lerner
发明人： Carlos Barbas , Richard Lerner
CPC分类号： C40B40/02 , C07H21/00 , C07K16/00 , C07K16/005 , C07K16/18 , C07K16/2848 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2318/10 , C12N15/1037
摘要： The present invention describes methods for producing binding sites on polypeptides, and particularly for producing binding sites within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles. The invention also describes oligonucleotides useful for preparing the binding sites, and human monoclonal antibodies produced by the present methods.
摘要翻译： 本发明描述了在多肽上产生结合位点，特别是用于产生显示在丝状噬菌体颗粒表面上的免疫球蛋白重链或轻链的CDR区内的结合位点的方法。 本发明还描述了可用于制备结合位点的寡核苷酸，以及通过本发明方法产生的人单克隆抗体。
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公开(公告)号：US20070207475A1
公开(公告)日：2007-09-06
申请号：US11560769
申请日：2006-11-16
申请人： William Huse , Gregory Winter , Lutz Riechmann , Joseph Sorge , Richard Lerner
发明人： William Huse , Gregory Winter , Lutz Riechmann , Joseph Sorge , Richard Lerner
CPC分类号： C07K16/005 , A61K38/00 , C07K16/00 , C07K16/44 , C07K16/468 , C07K2317/55 , C07K2317/56
摘要： The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.
摘要翻译： 本发明涉及从免疫基因库中分离编码具有结合预选配体的能力的受体的基因的方法。 还考虑了通过该方法分离的基因产生的受体，特别是催化受体。
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公开(公告)号：US20050085557A1
公开(公告)日：2005-04-21
申请号：US10934795
申请日：2004-09-03
申请人： Paul Wentworth , Richard Lerner
发明人： Paul Wentworth , Richard Lerner
IPC分类号： A61K31/12 , A61K31/56 , A61K31/575 , A61K39/385 , A61K39/44 , C07C49/105 , C07C49/403 , C07C49/507 , C07C49/633 , C07D313/04 , C07J9/00 , C07J61/00
CPC分类号： C07J61/00 , C07C49/523 , C07C49/757 , C07C59/353 , C07D313/04 , C07J9/00 , C07J9/005
摘要： As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cytotoxic cholesterol oxidation or ozonation products. The present application is directed to the products of cholesterol ozonation, binding entities directed against such products, and methods of using such binding entities and cytotoxins to treat a variety of diseases.
摘要翻译： 如本文所示，当胆固醇存在于动脉粥样硬化斑块中时，胆固醇被氧化。 该反应产生细胞毒性胆固醇氧化或臭氧化产物。 本申请涉及胆固醇臭氧化产物，针对这些产品的结合实体，以及使用这些结合实体和细胞毒素治疗各种疾病的方法。
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