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    Diagnosis of sepsis or SIRS using biomarker profiles
    4.
    发明授权
    Diagnosis of sepsis or SIRS using biomarker profiles 有权
    使用生物标志物图谱诊断败血症或SIRS

    公开(公告)号：US07645573B2

    公开(公告)日：2010-01-12

    申请号：US10704666

    申请日：2003-11-12

    申请人： Richard M. Ivey ,  Thomas M. Gentle, Jr. ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur, Jr. ,  Robert W. Rosenstein ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    发明人： Richard M. Ivey ,  Thomas M. Gentle, Jr. ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur, Jr. ,  Robert W. Rosenstein ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

    摘要翻译： 败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。 使用分子诊断方法实现早期预测或诊断，包括将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较，其可包括发生败血症的群体。 识别个体生物标志物特征的特征是脓毒症发作的特征，允许临床医生在单个时间点从个体分离的体液诊断败血症的发作。 因此，避免在一段时间内监测患者的必要性，有利地允许在严重症状发作之前进行临床干预。 此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。 个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

    Diagnosis of sepsis or SIRS using biomarker profiles
    5.
    发明申请
    Diagnosis of sepsis or SIRS using biomarker profiles 审中-公开
    使用生物标志物图谱诊断败血症或SIRS

    公开(公告)号：US20080138832A1

    公开(公告)日：2008-06-12

    申请号：US11904282

    申请日：2007-09-25

    申请人： Richard M. Ivey ,  Thomas M. Gentle ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur ,  Robert W. Rosenstein ,  James G. Nadeau ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    发明人： Richard M. Ivey ,  Thomas M. Gentle ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur ,  Robert W. Rosenstein ,  James G. Nadeau ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    IPC分类号： G01N33/53 ,  C12Q1/02 ,  G01N33/00

    CPC分类号： G01N33/6803 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

    摘要翻译： 败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。 通过将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较来实现早期预测或诊断，其可包括发生败血症的群体。 识别个体生物标志物特征的特征是脓毒症发作的特征允许临床医生在单个时间点诊断从个体分离的体液的败血症发作。 因此，避免在一段时间内监测患者的必要性，有利地允许在脓毒症严重症状发作之前进行临床干预。 此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。 个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

    Transparent sample container
    7.
    发明授权
    Transparent sample container 有权
    透明样品容器

    公开(公告)号：US06432697B1

    公开(公告)日：2002-08-13

    申请号：US09496775

    申请日：2000-02-03

    申请人： Gregory Tice ,  Ming-Hsiung Yeh ,  Thomas M. Gentle, Jr. ,  Timothy M. Sullivan

    发明人： Gregory Tice ,  Ming-Hsiung Yeh ,  Thomas M. Gentle, Jr. ,  Timothy M. Sullivan

    IPC分类号： C12M124

    CPC分类号： C12M23/08

    摘要： The present invention relates to a transparent sample container containing, preferably, a liquid bacterial growth media for detecting microbacteria and a process for detecting microbacteria using this sample container. The container is optically transparent, heat resistant, and stable during storage. The container and process provide a bacterial growth medium substantially free of contamination upon prolonged storage of preferably about one year at 40° C.

    摘要翻译： 本发明涉及一种透明的样品容器，其包含优选用于检测微生物的液体细菌生长培养基和使用该样品容器检测微生物的方法。 容器在光学透明，耐热和稳定的储存期间。 容器和方法提供基本上不受污染的细菌生长培养基，优选在40℃下长达一年。

    Method for reducing blood carbon dioxide background in bacterial media by the addition of micelles of saponin and a phospholipid
    9.
    发明授权
    Method for reducing blood carbon dioxide background in bacterial media by the addition of micelles of saponin and a phospholipid 失效
    通过加入皂角苷和磷脂的胶束来减少细菌培养基中血二氧化碳背景的方法

    公开(公告)号：US4994378A

    公开(公告)日：1991-02-19

    申请号：US404475

    申请日：1989-09-08

    申请人： Dolores M. Berger ,  Paul E. Goldenbaum ,  Gregory Tice

    发明人： Dolores M. Berger ,  Paul E. Goldenbaum ,  Gregory Tice

    IPC分类号： C12Q1/04

    CPC分类号： C12Q1/04

    摘要： A non-ionic lytic agent, preferably saponin for reducing the background carbon dioxide produced by blood cell metabolism is used in the testing of cultures for the presence of microorganisms. The hemolytic agent saponin is combined with a phospholipid, preferably L-.alpha.-Lecithin (phosphatidylcholine), to form mixed micelles which protect saponin from the effects of heat sterilization and high blood cholesterol levels, thus maintaining the lytic activity of saponin. The phospholipid/saponin mixed micelles are added to non-radiometric culture media vials such as Bactec.RTM. NR6A, NR7A and NR8A. The media vials are used in the Bactec.RTM. NR-660 and NR-730 instruments. However, the present invention may also be used in radiometric media such as Bactec.RTM. culture vials 6, 7 and 8 for reducing background carbon dioxide levels detected in C.sup.14 radiometric instruments such as the Bactec.RTM.-460, or in other instruments designed to detect bacteria in the presence of mammalian cells by monitoring the increase in CO.sub.2 produced by the metabolizing bacteria.

    摘要翻译： 用于减少血液细胞代谢产生的背景二氧化碳的非离子溶解剂，优选皂苷用于微生物存在的培养物的测试中。 溶血剂皂苷与磷脂，优选L-α-卵磷脂（磷脂酰胆碱）组合形成混合的胶束，其保护皂苷免受热灭菌和高血胆固醇水平的影响，从而保持皂角苷的溶解活性。 将磷脂/皂角苷混合胶束加入非辐射培养基小瓶如Bactec TM NR6A，NR7A和NR8A。 介质小瓶用于Bactec TM NR-660和NR-730仪器。 然而，本发明也可以用于辐射介质如Bactec TM培养瓶6,7和8中，用于降低C14辐射仪器如Bactec TM -460中检测到的背景二氧化碳水平，或用于其他设计用于检测细菌的仪器 在哺乳动物细胞的存在下，通过监测由代谢细菌产生的CO 2的增加。

    SYSTEMS AND METHODS FOR ELECTROFORMING DOMES FOR USE IN DOME SWITCHES
    10.
    发明申请
    SYSTEMS AND METHODS FOR ELECTROFORMING DOMES FOR USE IN DOME SWITCHES 审中-公开
    用于电脑切换的家用电器的系统和方法

    公开(公告)号：US20130071683A1

    公开(公告)日：2013-03-21

    申请号：US13238461

    申请日：2011-09-21

    申请人： John C. DiFonzo ,  Michael Hillman ,  Christiaan Ligtenberg ,  Gregory Tice

    发明人： John C. DiFonzo ,  Michael Hillman ,  Christiaan Ligtenberg ,  Gregory Tice

    IPC分类号： C25D1/00 ,  B32B3/28

    CPC分类号： C25D1/003 ,  C25D1/02 ,  C25D1/10 ,  C25D1/20 ,  H01H2215/004 ,  Y10T428/1241

    摘要： Systems and methods are provided for electroforming a dome for use in a dome switch. A mandrel having several dome shapes incorporated in a planar surface is provided. The mandrel can serve as a cathode in an electroforming process to construct a sheet of domes, for example by enabling the deposition of a sheet of nickel on the mandrel. The domes can be singulated from the sheet for use as part of dome switches. The electroforming process may ensure that the domes have a uniform thickness and no internal stresses that may affect the performance of the domes.

    摘要翻译： 提供了用于电铸圆顶以用于圆顶开关的系统和方法。 提供了具有并入平面的多个圆顶形状的心轴。 心轴可以在电铸工艺中用作阴极，以构造穹顶片，例如通过使镍片沉积在心轴上。 圆顶可以从片材中分离出来用作圆顶开关的一部分。 电铸工艺可以确保圆顶具有均匀的厚度并且不会影响可能影响圆顶的性能的内部应力。