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    Diagnosis of sepsis or SIRS using biomarker profiles
    5.
    发明授权
    Diagnosis of sepsis or SIRS using biomarker profiles 有权
    使用生物标志物图谱诊断败血症或SIRS

    公开(公告)号：US07645573B2

    公开(公告)日：2010-01-12

    申请号：US10704666

    申请日：2003-11-12

    申请人： Richard M. Ivey ,  Thomas M. Gentle, Jr. ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur, Jr. ,  Robert W. Rosenstein ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    发明人： Richard M. Ivey ,  Thomas M. Gentle, Jr. ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur, Jr. ,  Robert W. Rosenstein ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

    摘要翻译： 败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。 使用分子诊断方法实现早期预测或诊断，包括将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较，其可包括发生败血症的群体。 识别个体生物标志物特征的特征是脓毒症发作的特征，允许临床医生在单个时间点从个体分离的体液诊断败血症的发作。 因此，避免在一段时间内监测患者的必要性，有利地允许在严重症状发作之前进行临床干预。 此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。 个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

    Diagnosis of sepsis or SIRS using biomarker profiles
    6.
    发明申请
    Diagnosis of sepsis or SIRS using biomarker profiles 审中-公开
    使用生物标志物图谱诊断败血症或SIRS

    公开(公告)号：US20080138832A1

    公开(公告)日：2008-06-12

    申请号：US11904282

    申请日：2007-09-25

    申请人： Richard M. Ivey ,  Thomas M. Gentle ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur ,  Robert W. Rosenstein ,  James G. Nadeau ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    发明人： Richard M. Ivey ,  Thomas M. Gentle ,  Richard L. Moore ,  Michael L. Towns ,  Nicholas Bachur ,  Robert W. Rosenstein ,  James G. Nadeau ,  Paul E. Goldenbaum ,  Song Shi ,  Donald Copertino ,  James Garrett ,  Gregory Tice

    IPC分类号： G01N33/53 ,  C12Q1/02 ,  G01N33/00

    CPC分类号： G01N33/6803 ,  C12Q1/6837 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/26

    摘要： The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.

    摘要翻译： 败血症的早期预测或诊断有利地允许在疾病快速进展到初始阶段之前的临床干预到更严重的阶段，例如与高死亡率相关的更严重的败血症或败血性休克。 通过将个体的生物标志物表达谱与从一个或多个对照或参考群体获得的概况进行比较来实现早期预测或诊断，其可包括发生败血症的群体。 识别个体生物标志物特征的特征是脓毒症发作的特征允许临床医生在单个时间点诊断从个体分离的体液的败血症发作。 因此，避免在一段时间内监测患者的必要性，有利地允许在脓毒症严重症状发作之前进行临床干预。 此外，因为生物标志物的表达被测定其特征，所以特定生物标志物的鉴定是不必要的。 个体的生物标记谱与适当参考群的生物标志物概况的比较同样可以用于诊断个体中的SIRS。

    SYSTEMS AND METHODS FOR ELECTROFORMING DOMES FOR USE IN DOME SWITCHES
    7.
    发明申请
    SYSTEMS AND METHODS FOR ELECTROFORMING DOMES FOR USE IN DOME SWITCHES 审中-公开
    用于电脑切换的家用电器的系统和方法

    公开(公告)号：US20130071683A1

    公开(公告)日：2013-03-21

    申请号：US13238461

    申请日：2011-09-21

    申请人： John C. DiFonzo ,  Michael Hillman ,  Christiaan Ligtenberg ,  Gregory Tice

    发明人： John C. DiFonzo ,  Michael Hillman ,  Christiaan Ligtenberg ,  Gregory Tice

    IPC分类号： C25D1/00 ,  B32B3/28

    CPC分类号： C25D1/003 ,  C25D1/02 ,  C25D1/10 ,  C25D1/20 ,  H01H2215/004 ,  Y10T428/1241

    摘要： Systems and methods are provided for electroforming a dome for use in a dome switch. A mandrel having several dome shapes incorporated in a planar surface is provided. The mandrel can serve as a cathode in an electroforming process to construct a sheet of domes, for example by enabling the deposition of a sheet of nickel on the mandrel. The domes can be singulated from the sheet for use as part of dome switches. The electroforming process may ensure that the domes have a uniform thickness and no internal stresses that may affect the performance of the domes.

    摘要翻译： 提供了用于电铸圆顶以用于圆顶开关的系统和方法。 提供了具有并入平面的多个圆顶形状的心轴。 心轴可以在电铸工艺中用作阴极，以构造穹顶片，例如通过使镍片沉积在心轴上。 圆顶可以从片材中分离出来用作圆顶开关的一部分。 电铸工艺可以确保圆顶具有均匀的厚度并且不会影响可能影响圆顶的性能的内部应力。

    System for controlling septum damage
    8.
    发明授权
    System for controlling septum damage 失效
    用于控制隔膜损伤的系统

    公开(公告)号：US4517851A

    公开(公告)日：1985-05-21

    申请号：US496716

    申请日：1983-05-20

    申请人： Gregory Tice

    发明人： Gregory Tice

    IPC分类号： B65G15/58 ,  G01N30/04 ,  G01N30/18 ,  G01N35/00

    CPC分类号： G01N30/18

    摘要： The present invention is directed to a system for locating a vial in a predetermined location with respect to a needle which is used to penetrate a septum in the vial. The system includes a vial carrier having a well for receiving a vial. A penetrable septum is disposed in an opening in the vial. At least one needle penetrates the septum at periodic intervals. Locating means are provided within the vial carrier for establishing a predetermined location of the vial in relation to the needle. The locating means includes a plurality of contact points and urging means for establishing contact between the contact points and the locating surface. The urging means presses substantially on one side of the vial, which side is substantially opposite the locating means.

    摘要翻译： 本发明涉及一种用于将小瓶定位在相对于用于穿透小瓶中的隔膜的针的预定位置的系统。 该系统包括具有用于接收小瓶的孔的小瓶托架。 可穿透的隔膜设置在小瓶的开口中。 至少一根针头以周期性间隔穿透隔膜。 定位装置设置在小瓶托架内，用于相对于针建立小瓶的预定位置。 定位装置包括多个接触点和用于建立接触点和定位表面之间的接触的推动装置。 推动装置基本上压在小瓶的一侧，该侧基本上与定位装置相对。

    Method of assembling integrated circuit components
    10.
    发明授权
    Method of assembling integrated circuit components 有权
    集成电路组件的组装方法

    公开(公告)号：US08039360B2

    公开(公告)日：2011-10-18

    申请号：US12241933

    申请日：2008-09-30

    申请人： Bradley Spare ,  Michael D. Hillman ,  Gregory Tice

    发明人： Bradley Spare ,  Michael D. Hillman ,  Gregory Tice

    IPC分类号： H01L21/30

    CPC分类号： H01L31/188 ,  H01L24/81 ,  H01L24/83 ,  H01L2224/81801 ,  H01L2224/83194 ,  H01L2224/83801 ,  H01L2924/12043 ,  H01L2924/14 ,  Y02E10/50 ,  H01L2924/00

    摘要： The disclosure identified as methods of mounting integrated circuits, including solar cells, to a substrate wherein the circuits are mounted prior to being singulated into discrete die. Once the semiconductor die sites or other circuits are formed on a wafer, the wafer will be attached, either whole, or divided into one or more multi-die site wafer segments, to a substrate. This attachment may be by conventional surface mount technology, for example. After such mounting, the individual die sites on the wafer segments will be singulated to form discrete die already mounted to the supporting substrate. The singulation may be preferably performed by laser dicing of the wafer segments.

    摘要翻译： 本公开被确定为将集成电路（包括太阳能电池）安装到基板的方法，其中在将单元切割成离散模具之前将电路安装在基板上。 一旦在晶片上形成半导体芯片位置或其它电路，则晶片将被整体地或分成一个或多个多晶片位置晶片段而连接到衬底。 该附件可以是例如常规的表面贴装技术。 在这种安装之后，晶片段上的各个晶片位置将被单独化以形成已经安装到支撑衬底上的离散模具。 单片化可以优选地通过晶片片段的激光切割来进行。