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公开(公告)号：US4252668A
公开(公告)日：1981-02-24
申请号：US14179
申请日：1979-02-22
CPC分类号： G21G1/10 , A61K51/02 , A61K51/121 , A61K51/1282 , A61K2123/00 , F16D2001/062
摘要： A solution of potassium-38 suitable for use as a radiopharmaceutical and a method for its production. Argon is irradiated with protons having energies above the threshold for the .sup.40 Ar(p,3n).sup.38 K reaction. The resulting potassium-38 is dissolved in a sterile water and any contaminating chlorine-38 is removed.
摘要翻译： 适合用作放射性药物的一种钾38的溶液及其生产方法。 用能量超过40Ar（p，3n）38K反应阈值的质子照射氩。 将所得的钾38溶于无菌水中，并除去任何污染的氯-38。
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公开(公告)号：US3959455A
公开(公告)日：1976-05-25
申请号：US592305
申请日：1975-07-01
CPC分类号： G21H5/02 , A61K51/04 , A61K51/0485 , A61K2123/00
摘要： The method of labeling indocyanine green (ICG) with carrier-free iodine-123 comprising the steps of condensing xenon-123 on crystals of ICG followed by permitting decay of the .sup.123 Xe a sufficient length of time to produce .sup.123 I-electronically excited ions and atoms which subsequently label ICG.
摘要翻译： 用无载体碘-123标记吲哚菁绿（ICG）的方法包括以下步骤：将氙-123在ICG晶体上冷凝，然后允许123Xe衰变足够长的时间以产生123I-电子激发的离子和原子， 随后标签ICG。
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公开(公告)号：US4011307A
公开(公告)日：1977-03-08
申请号：US692625
申请日：1976-06-03
申请人： Richard M. Lambrecht , Samuel Packer , Jerald C. Merrill , Harold L. Atkins , Alfred P. Wolf , Patrick R. Bradley-Moore
发明人： Richard M. Lambrecht , Samuel Packer , Jerald C. Merrill , Harold L. Atkins , Alfred P. Wolf , Patrick R. Bradley-Moore
CPC分类号： G21H5/02 , A61K51/0478 , G21G1/10 , A61K2123/00
摘要： .sup.203 Pb-tris complex injected for use in the detection and localization of tumors. The lead-203 is produced from the deuteron bombardment of a thallium target and chemically separated from the thallium. The tris is added which complexes with the lead-203.
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公开(公告)号：US4162142A
公开(公告)日：1979-07-24
申请号：US920412
申请日：1978-06-29
CPC分类号： G21H5/02 , Y10S436/804 , Y10S930/13
摘要： An improved process for labeling organic compounds with tritium is carried out by depositing the selected compound on the extensive surface of a porous structure such as a membrane filter and exposing the membrane containing the compound to tritium gas activated by the microwave discharge technique. The labeled compound is then recovered from the porous structure.
摘要翻译： 通过将选择的化合物沉积在诸如膜过滤器的多孔结构的广泛表面上并将含有化合物的膜暴露于通过微波放电技术活化的氚气中来进行用氚标记有机化合物的改进方法。 然后从多孔结构中回收标记的化合物。
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公开(公告)号：US4439414A
公开(公告)日：1984-03-27
申请号：US342684
申请日：1982-01-26
申请人： Chyng-Yann Shiue , Alfred P. Wolf
发明人： Chyng-Yann Shiue , Alfred P. Wolf
CPC分类号： A61K51/00
摘要： The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.
摘要翻译： 新化合物1-11C-D-葡萄糖，1-11C-D-甘露糖，1-11C-D-半乳糖，2-11C-D-葡萄糖，2-11C-D-甘露糖和2-11C-D-半乳糖 可以用于核医学监测葡萄糖和半乳糖的代谢，可以通过合适的醛糖底物与碱金属11C标记的氰化物反应，然后用阮内合金在甲酸中还原，快速制备。
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公开(公告)号：US4913891A
公开(公告)日：1990-04-03
申请号：US52921
申请日：1987-05-22
IPC分类号： A61K51/04
CPC分类号： A61K51/0406 , A61K2123/00
摘要： This invention involves a new strategy for imaging and mapping enzyme activity in the living human and animal body using positron emitter-labeled suicide enzyme inactivators or inhibitors which become covalently bound to the enzyme as a result of enzymatic catalysis. Two such suicide inactivators for monoamine oxidase have been labeled with carbon-11 and used to map the enzyme subtypes in the living human and animal body using PET. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography.
摘要翻译： 本发明涉及使用正电子发射体标记的自杀酶灭活剂或由于酶促催化而与酶共价结合的抑制剂在活的人和动物体中成像和测定酶活性的新策略。 已经用碳-11标记了两种用于单胺氧化酶的这种自杀灭活剂，并且用于使用PET对活的人和动物体中的酶亚型进行映射。 通过使用正电子发射断层扫描来对由碳-11发射的身体穿透辐射产生的放射性分布进行成像，获得功能活性单胺氧化酶活性的图谱。 Clorgyline和L-去肾上腺素是自杀性酶抑制剂，并且不可逆地抑制单胺氧化酶。 当这些抑制剂用碳-11标记时，它们使用正电子发射断层扫描为体内单胺氧化酶定位和反应性提供选择性探针。
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7.发明授权
公开(公告)号：US4617386A
公开(公告)日：1986-10-14
申请号：US488311
申请日：1983-04-25
摘要： Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopyranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.
摘要翻译： 制备2-脱氧-2-氟-D-葡萄糖的方法和相应的18F-化合物，其中甲基4,6-O-亚苄基-3-O-甲基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖苷 与三氟甲烷试剂反应，所得化合物与CsHF 2，RbF或相应的18 F化合物反应，然后通过水解除去烷基。
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公开(公告)号：USH74H
公开(公告)日：1986-06-03
申请号：US469597
申请日：1983-02-24
申请人： Chyng-Yann Shiue , Piero A. Salvadori , Alfred P. Wolf , Joanna S. Fowler , Robert R. MacGregor
发明人： Chyng-Yann Shiue , Piero A. Salvadori , Alfred P. Wolf , Joanna S. Fowler , Robert R. MacGregor
IPC分类号： C07H5/02
CPC分类号： C07H5/02
摘要： Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound by the reaction of acetyl hypofluorite or the corresponding .sup.18 F-compound with 3,4,6-tri-O-acetyl-D-glucal followed by hydrolysis. Process includes the production of the hypofluorite compound at ambient temperature.
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公开(公告)号：US4436717A
公开(公告)日：1984-03-13
申请号：US268422
申请日：1981-05-29
申请人： Chyng-Yann Shiue , Alfred P. Wolf
发明人： Chyng-Yann Shiue , Alfred P. Wolf
CPC分类号： A61K51/0453 , A61K2123/00
摘要： The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.
摘要翻译： 在诊断应用中可用于核医学中的具有高比活性的新型放射性化合物18F-4-氟替平吡啶，其通过在室温下用放射性氟在乙酸中直接氟化安替比林并通过凝胶色谱法纯化所述放射性化合物 公开了乙酸乙酯作为洗脱剂。 非放射性4-氟替苯胺也可以通过在室温下用分配氟在乙酸中直接氟化安替比林并通过乙酸乙酯洗脱液的凝胶色谱法纯化来制备。
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10.发明授权No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic aromatic substitution of electron rich aromatic rings 失效无载体添加（NCA）芳基（18E）氟化物通过富含芳族芳环的亲核芳烃取代
公开(公告)号：US5254726A
公开(公告)日：1993-10-19
申请号：US711684
申请日：1991-06-07
申请人： Yu-Shin Ding , Joanna S. Fowler , Alfred P. Wolf
发明人： Yu-Shin Ding , Joanna S. Fowler , Alfred P. Wolf
IPC分类号： C07C215/28 , C07C229/36 , C07D317/62 , C07C229/42 , C07C47/52 , C07C213/08
CPC分类号： C07C229/36 , C07C215/28 , C07D317/62
摘要： A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction isThe U.S. Government has rights in this invention pursuant to Contract Number DE-AC02-76CH00016, between the U.S. Department of Energy and Associated Universities Inc.
摘要翻译： 描述了一种合成具有给电子基团的无载体添加（NCA）芳基[18 F]氟取代的芳族醛组合物的方法。 本发明的方法包括使具有适当保护的羟基取代基的芳族硝基醛与富电子环反应的步骤。 该反应通过亲核芳族取代通过无载体添加（NCA）[18F]氟离子进行。 本发明的方法可用于合成各种无载体添加的芳基[18 F]氟化物组合物，包括6- [18 F]氟-L-多巴，2- [18 F]氟酪氨酸，6- [18 F]氟去甲肾上腺素， 和6- [18F]氟代多巴胺。 在通过本发明产生对映异构体的外消旋混合物的情况下，例如在6- [18 F]氟去甲肾上腺素的合成中，优选的方法还包括在手性HPLC柱上拆分外消旋混合物。 该方法导致高产率的对映体纯的[18 F]标记的异构体，例如[ - ] - 6- [18 F]氟去甲肾上腺素和[+] - 6- [18F]氟去甲肾上腺素。
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