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15 条记录 (耗时 0.014 秒)

    No-carrier-added (18F)-N-methylspiroperidol
    1.
    依法登记的发明
    No-carrier-added (18F)-N-methylspiroperidol 失效

    公开(公告)号：USH1209H

    公开(公告)日：1993-07-06

    申请号：US784149

    申请日：1985-10-04

    申请人： Chyng-Yann Shiue ,  Joanna S. Fowler ,  Alfred P. Wolf

    发明人： Chyng-Yann Shiue ,  Joanna S. Fowler ,  Alfred P. Wolf

    IPC分类号： A61K51/04

    CPC分类号： A61K51/0455 ,  A61K2123/00

    摘要： There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

    No-carrier-added [.sup.18 F]-N-fluoroalkylspiroperidols
    2.
    发明授权
    No-carrier-added [.sup.18 F]-N-fluoroalkylspiroperidols 失效
    无载体添加[18 F] -N-氟烷基螺环脂醇

    公开(公告)号：US4871527A

    公开(公告)日：1989-10-03

    申请号：US43824

    申请日：1987-04-29

    申请人： Chyng-Yann Shiue ,  Alfred P. Wolf ,  Lan-Qin Bai ,  Ren-Tui Teng

    发明人： Chyng-Yann Shiue ,  Alfred P. Wolf ,  Lan-Qin Bai ,  Ren-Tui Teng

    IPC分类号： A61K51/04

    CPC分类号： C07B59/002 ,  A61K51/0455 ,  A61K2123/00

    摘要： There is disclosed radioligands labeled with the position emitting radionuclide [.sup.18 F] suitable for dynamic study in living humans with position emission transaxial tomography. These new [.sup.18 F]-N-fluoroalkylspiroperidols, wherein the alkyl group contains from 2-6 carbon atoms, exhibit extremely high affinity for the dopamine receptors and provide enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to make these new radioligands useful for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for these radioligands as well as a new procedure for preparing the radiolabeled alkyl halide alkylating reagents are also disclosed.

    摘要翻译： 公开了放射性核素标记的放射性核素[18F]的位置，适用于活体位置发射横轴断层扫描的动态研究。 这些新的[18 F] -N-氟烷基螺环脂醇，其中烷基含有2-6个碳原子，对多巴胺受体表现出非常高的亲和力，并且随着减少的辐射负担而提供增强的大脑摄取和保留。 这些特征都结合起来，使这些新的放射性配体可用于在活体大脑的正常和疾病状态下测定多巴胺受体。 此外，还公开了这些放射性配体的新合成方法以及制备放射性标记的烷基卤烷基化试剂的新方法。

    .sup.18 F-4-Fluoroantipyrine
    5.
    发明授权
    .sup.18 F-4-Fluoroantipyrine 失效
    18F-4-氟安替比林

    公开(公告)号：US4436717A

    公开(公告)日：1984-03-13

    申请号：US268422

    申请日：1981-05-29

    申请人： Chyng-Yann Shiue ,  Alfred P. Wolf

    发明人： Chyng-Yann Shiue ,  Alfred P. Wolf

    IPC分类号： A61K51/04 ,  A61K43/00 ,  A61K49/00

    CPC分类号： A61K51/0453 ,  A61K2123/00

    摘要： The novel radioactive compound .sup.18 F-4-fluoroantipyrine having high specific activity which can be used in nuclear medicine in diagnostic applications, prepared by the direct fluorination of antipyrine in acetic acid with radioactive fluorine at room temperature and purifying said radioactive compound by means of gel chromatography with ethyl acetate as eluent is disclosed. The non-radioactive 4-fluoroantipyrine can also be prepared by the direct fluorination of antipyrine in acetic acid with molecular fluorine at room temperature and purified by means of gel chromotography with ethyl acetate eluent.

    摘要翻译： 在诊断应用中可用于核医学中的具有高比活性的新型放射性化合物18F-4-氟替平吡啶，其通过在室温下用放射性氟在乙酸中直接氟化安替比林并通过凝胶色谱法纯化所述放射性化合物 公开了乙酸乙酯作为洗脱剂。 非放射性4-氟替苯胺也可以通过在室温下用分配氟在乙酸中直接氟化安替比林并通过乙酸乙酯洗脱液的凝胶色谱法纯化来制备。

    1-.sup.11 C-D-Glucose and related compounds
    6.
    发明授权
    1-.sup.11 C-D-Glucose and related compounds 失效
    1-11C-D-葡萄糖及相关化合物

    公开(公告)号：US4439414A

    公开(公告)日：1984-03-27

    申请号：US342684

    申请日：1982-01-26

    申请人： Chyng-Yann Shiue ,  Alfred P. Wolf

    发明人： Chyng-Yann Shiue ,  Alfred P. Wolf

    IPC分类号： A61K51/00 ,  A61K49/02

    CPC分类号： A61K51/00

    摘要： The novel compounds 1-.sup.11 C-D-glucose, 1-.sup.11 C-D-mannose, 1-.sup.11 C-D-galactose, 2-.sup.11 C-D-glucose, 2-.sup.11 C-D-mannose and 2-.sup.11 C-D-galactose which can be used in nuclear medicine to monitor the metabolism of glucose and galactose can be rapidly prepared by reaction of the appropriate aldose substrate with an alkali metal .sup.11 C-labeled cyanide followed by reduction with a Raney alloy in formic acid.

    摘要翻译： 新化合物1-11C-D-葡萄糖，1-11C-D-甘露糖，1-11C-D-半乳糖，2-11C-D-葡萄糖，2-11C-D-甘露糖和2-11C-D-半乳糖 可以用于核医学监测葡萄糖和半乳糖的代谢，可以通过合适的醛糖底物与碱金属11C标记的氰化物反应，然后用阮内合金在甲酸中还原，快速制备。

    Detection of hypoxia
    7.
    发明申请
    Detection of hypoxia 审中-公开
    检测缺氧

    公开(公告)号：US20050026974A1

    公开(公告)日：2005-02-03

    申请号：US10927696

    申请日：2004-08-27

    申请人： Cameron Koch ,  Alexander Kachur ,  Sydney Evans ,  Chyng-Yann Shiue ,  Ian Baird ,  Kirsten Skov ,  William Dolbier ,  An-Rong Li ,  Brian James

    发明人： Cameron Koch ,  Alexander Kachur ,  Sydney Evans ,  Chyng-Yann Shiue ,  Ian Baird ,  Kirsten Skov ,  William Dolbier ,  An-Rong Li ,  Brian James

    IPC分类号： C07D233/91 ,  C07D277/38 ,  C07K16/44 ,  A61K31/426

    CPC分类号： C07D233/91 ,  C07K16/44

    摘要： Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

    摘要翻译： 公开了包含新型硝基芳族化合物和载体蛋白质的新型硝基芳族化合物和免疫原性缀合物。 本发明还提供对所要求保护的硝基芳族化合物，化合物的蛋白质缀合物，化合物的还原副产物以及化合物和哺乳动物缺氧细胞组织蛋白质之间形成的加合物高度特异性的单克隆抗体。 本发明还涉及使用免疫组织化学技术，非侵入性核医学方法或核磁共振来检测组织缺氧的方法。 还提供了可用于实践所要求保护的发明的方法的诊断试剂盒。