公开(公告)号：US4372745A

公开(公告)日：1983-02-08

申请号：US233057

申请日：1981-02-10

申请人： Richard M. Mandle ,  Yuan N. Wong

发明人： Richard M. Mandle ,  Yuan N. Wong

IPC分类号： G01N33/58 ,  G01N33/54 ,  G01N33/52

CPC分类号： G01N33/582 ,  G01N33/586 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/826

摘要： A system for the detection of a biological analyte of interest is disclosed which comprises a microencapsulated fluorescer material which has been conjugated to an immunological specie specific to the biological analyte of interest, a means of disrupting the capsule containing the fluorescer and an energy source other than electro-magnetic radiation which is capable of activating the fluorescer. A method for the qualitative and/or quantitative detection of a biological of interest is disclosed, which comprises: (a) labeling an immunological specie specific to the analyte of interest with a microencapsulated fluorescer material which is biologically compatible with such specie;(b) contacting the microencapsulated fluorescer labeled specie and the biological of interest to form a microencapsulated fluorescer labeled specie/biological complex;(c) separating the microencapsulated fluorescer labeled specie/biological complex;(d) distrupting the capsule containing the fluorescer label thus freeing it to solution;(e) contacting the freed fluorescer with an energy source other than electro-magnetic radiation which is capable of activating the fluorescer label; and(f) determining the presence of and/or measuring the quantity of chemiluminescent light emitted.

摘要翻译： 公开了一种用于检测感兴趣的生物分析物的系统，其包含已经与感兴趣的生物分析物特异性的免疫学特异性结合的微囊化荧光剂材料，破坏包含荧光剂的胶囊和除了 能够激活荧光剂的电磁辐射。 公开了用于定性和/或定量检测感兴趣的生物学的方法，其包括：（a）用与这种物质生物相容的微囊化荧光剂材料标记对目标分析物特异性的免疫学物种; （b）使微囊化的荧光物质标记的物质和感兴趣的生物学接触以形成微囊化的荧光剂标记的物种/生物复合物; （c）分离微囊化的荧光剂标记的物种/生物复合物; （d）破坏含有荧光标签的胶囊，从而释放出溶液; （e）使除去的荧光剂与能够激活荧光标记物的电磁辐射以外的能量源接触; 和（f）确定发射的化学发光光的量的存在和/或测量。

公开(公告)号：US5951357A

公开(公告)日：1999-09-14

申请号：US773744

申请日：1996-12-17

申请人： Richard M. Mandle ,  Theodore Roxbury

发明人： Richard M. Mandle ,  Theodore Roxbury

IPC分类号： A63C19/10 ,  A63H13/04 ,  A63H33/26 ,  A63H33/30 ,  A63H11/00 ,  A63H29/08

CPC分类号： A63H33/30 ,  A63C19/10 ,  A63H13/04 ,  A63H33/26

摘要： A magnetic strip of material formed into a loop which is placed around two pulleys. The pulleys rotate, thereby moving the magnetic strip. Skiers have skis which are attracted to the magnetic strip and are thereby moved with the loop as the loop is pulled around the pulleys. As the skier reaches the top of the upper pulley, the ski is lifted off the magnetic strip and onto the ski jump ramp. At the top of this ramp, the skier is held by a magnet located beneath the top of the ramp. Rotating with the upper pulley is a cam which moves the magnet at the top of the ramp between two positions. The first positions holds the magnet against or adjacent to the underside of the ramp holding the skier at the top of the ramp and the second position holds the magnet rotated slightly away from the ramp which releases the figure to descend the ramp and perform its ski jump. Optionally there is a flag that drops when the magnet releases the skier. After the skier is released, he slides down and off the ramp and free falls until he lands on the magnetic strip. He is again held by magnetic force to the magnetic strip and drawn around the bottom of the lower pulley, back up around the top and onto the top of the ramp to make another jump.

摘要翻译： 形成为环绕两个滑轮的环形材料的磁条。 滑轮旋转，从而移动磁条。 滑雪者具有被吸引到磁条上的滑雪板，并且随着环绕拉轮滑动而随着环路的移动。 当滑雪者到达上部滑轮的顶部时，滑雪板从磁条上滑落到滑雪跳台上。 在这个坡道的顶部，滑雪者由位于坡道顶部下方的磁铁保持。 与上滑轮一起旋转的是在两个位置之间使斜坡顶部的磁体移动的凸轮。 第一位置将磁体抵靠或靠近斜坡的下侧，保持滑雪者在斜坡的顶部，并且第二位置保持磁体稍微远离斜坡旋转，释放图形以下降斜坡并执行其滑雪跳跃 。 可选地，当磁体释放滑雪者时，会出现一个标志。 滑雪者被释放后，他滑下坡道，自由落下，直到他滑落在磁条上。 他再次被磁力固定在磁条上，并绕着下滑轮的底部拉回，并绕着顶部回到斜坡的顶部，以进一步跳跃。

公开(公告)号：US5441418A

公开(公告)日：1995-08-15

申请号：US065549

申请日：1993-05-20

申请人： William E. Brown ,  Charles W. Dietterich ,  Richard M. Mandle

发明人： William E. Brown ,  Charles W. Dietterich ,  Richard M. Mandle

IPC分类号： B41M5/28 ,  G09B11/00

CPC分类号： G09B11/00 ,  B41M5/282

摘要： A thermochromic drawing device is disclosed which can be marked and erased by selectively changing the temperature of its drawing surface. The drawing surface of the drawing device consists of a flexible substrate printed with thermochromic inks having at least two color states. The flexible substrate has low thermal mass thereby enabling it to readily assimilate temperatures induced by a user and, consequently, facilitating the transition of the thermochromic inks from one color state to another. The drawing surface is further provided with an insulating layer which isolates the flexible substrate from unwanted heat sinks and heat sources thereby preventing unwanted color transitions of the thermochromic inks. Thus, a user can selectively change the color state of portions of the drawing surface to create distinctive markings.

摘要翻译： 公开了一种通过选择性地改变其拉制表面的温度来标记和擦除的热致变色拉丝装置。 拉伸装置的拉伸表面由具有至少两种颜色状态的热变色油墨印刷的柔性基材组成。 柔性基板具有低热量，从而使其能够容易地吸收用户感应的温度，从而促进热变色油墨从一种颜色状态到另一种颜色状态的转变。 拉伸表面还设置有绝缘层，其将柔性基板与不需要的散热器和热源隔离，从而防止热变色油墨的不期望的颜色转变。 因此，用户可以选择性地改变绘图表面的部分的颜色状态以产生不同的标记。

公开(公告)号：US4265855A

公开(公告)日：1981-05-05

申请号：US957091

申请日：1978-11-03

申请人： Richard M. Mandle ,  Frank Karsai ,  Raymond S. Krautheim

发明人： Richard M. Mandle ,  Frank Karsai ,  Raymond S. Krautheim

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N1/14

CPC分类号： G01N35/026 ,  G01N35/00732 ,  G01N2035/00762 ,  G01N2035/1025 ,  G01N35/0098

摘要： A system for automatically processing liquids in open-ended containers. The containers are moved past a plurality of operating stations that carry out the following operations: washing, reagent-adding, incubation, detection, and storage. The operating stations for washing and reagent-addition include vertically and horizontally movable assemblies for operating upon the containers. The containers are carried in groups in individual carrying blocks which are moved throughout the system.

摘要翻译： 用于在开放式容器中自动处理液体的系统。 容器移动通过执行以下操作的多个操作站：洗涤，试剂添加，孵育，检测和存储。 用于洗涤和试剂添加的操作站包括用于在容器上操作的垂直和水平移动的组件。 这些容器在各个承载块中分组搬运，这些承载块在整个系统中移动。

公开(公告)号：US4566790A

公开(公告)日：1986-01-28

申请号：US485174

申请日：1983-04-15

申请人： Richard M. Mandle

发明人： Richard M. Mandle

IPC分类号： G01N21/07 ,  G01N1/10

CPC分类号： G01N21/07

摘要： An improved cuvette array for a centrifugal analyzer is disclosed. The array is conventionally formed from upper and lower discs of flexible thermoplastic material, in which the lower disc is formed with a plurality of compartments circumferentially spaced about a first central hub, and the upper disc is bonded to the outer periphery of the lower disc and closes an outer peripheral portion of the compartments. The array is improved by forming the upper disc with a central portion that includes a second central hub positioned above the first central hub, together with an intermediate web that bridges the second central hub to the outer peripheral portion of the upper disc so as to close off the inner peripheral portion of the compartments. The intermediate web portion may be joined to the outer peripheral portion of the upper disc by a tearible score line to permit the central portion of the upper disc to be entirely removed.

摘要翻译： 公开了用于离心分析器的改进的比色皿阵列。 阵列通常由柔性热塑性材料的上和下盘形成，其中下盘形成有围绕第一中心毂周向隔开的多个隔室，并且上盘结合到下盘的外周， 封闭隔室的外围部分。 通过形成具有中心部分的上盘来改善阵列，该中心部分包​​括位于第一中心毂上方的第二中心毂，以及将第二中心毂桥接到上盘的外周部分以便闭合的中间腹板 脱离隔室的内周部分。 中间腹板部分可以通过可撕开的刻痕线连接到上盘的外周部分，以允许上盘的中心部分被完全去除。